 Tropomyosin
"Tropomyosin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein found in the thin filaments of muscle fibers. It inhibits contraction of the muscle unless its position is modified by TROPONIN.
| Descriptor ID |
D014335
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| MeSH Number(s) |
D05.750.078.730.800 D12.776.210.500.895 D12.776.220.525.800
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Tropomyosin".
Below are MeSH descriptors whose meaning is more specific than "Tropomyosin".
This graph shows the total number of publications written about "Tropomyosin" by people in this website by year, and whether "Tropomyosin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 1998 | 1 | 0 | 1 | | 1999 | 1 | 0 | 1 | | 2000 | 0 | 1 | 1 | | 2002 | 1 | 0 | 1 | | 2003 | 1 | 0 | 1 | | 2007 | 0 | 1 | 1 | | 2015 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Tropomyosin" by people in Profiles.
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Madan A, Viswanathan MC, Woulfe KC, Schmidt W, Sidor A, Liu T, Nguyen TH, Trinh B, Wilson C, Madathil S, Vogler G, O'Rourke B, Biesiadecki BJ, Tobacman LS, Cammarato A. TNNT2 mutations in the tropomyosin binding region of TNT1 disrupt its role in contractile inhibition and stimulate cardiac dysfunction. Proc Natl Acad Sci U S A. 2020 08 04; 117(31):18822-18831.
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Donkervoort S, Papadaki M, de Winter JM, Neu MB, Kirschner J, Bolduc V, Yang ML, Gibbons MA, Hu Y, Dastgir J, Leach ME, Rutkowski A, Foley AR, Kr?ger M, Wartchow EP, McNamara E, Ong R, Nowak KJ, Laing NG, Clarke NF, Ottenheijm C, Marston SB, B?nnemann CG. TPM3 deletions cause a hypercontractile congenital muscle stiffness phenotype. Ann Neurol. 2015 Dec; 78(6):982-994.
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Kirwan JP, Hodges RS. Transmission of stability information through the N-domain of tropomyosin is interrupted by a stabilizing mutation (A109L) in the hydrophobic core of the stability control region (residues 97-118). J Biol Chem. 2014 Feb 14; 289(7):4356-66.
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Kirwan JP, Hodges RS. Critical interactions in the stability control region of tropomyosin. J Struct Biol. 2010 May; 170(2):294-306.
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Zhang C, Jia P, Huang X, Sferrazza GF, Athauda G, Achary MP, Wang J, Lemanski SL, Dube DK, Lemanski LF. Myofibril-inducing RNA (MIR) is essential for tropomyosin expression and myofibrillogenesis in axolotl hearts. J Biomed Sci. 2009 Sep 03; 16:81.
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Hodges RS, Mills J, McReynolds S, Kirwan JP, Tripet B, Osguthorpe D. Identification of a unique "stability control region" that controls protein stability of tropomyosin: A two-stranded alpha-helical coiled-coil. J Mol Biol. 2009 Sep 25; 392(3):747-62.
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Lowes BD, Zolty R, Shakar SF, Brieke A, Gray N, Reed M, Calalb M, Minobe W, Lindenfeld J, Wolfel EE, Geraci M, Bristow MR, Cleveland J. Assist devices fail to reverse patterns of fetal gene expression despite beta-blockers. J Heart Lung Transplant. 2007 Nov; 26(11):1170-6.
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Weber RW. On the cover. German cockroach. Ann Allergy Asthma Immunol. 2007 Aug; 99(2):A4.
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Kwok SC, Hodges RS. Stabilizing and destabilizing clusters in the hydrophobic core of long two-stranded alpha-helical coiled-coils. J Biol Chem. 2004 May 14; 279(20):21576-88.
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Lu SM, Hodges RS. Defining the minimum size of a hydrophobic cluster in two-stranded alpha-helical coiled-coils: effects on protein stability. Protein Sci. 2004 Mar; 13(3):714-26.
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