 Tripartite Motif-Containing Protein 28
"Tripartite Motif-Containing Protein 28" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tripartite motif protein consisting of an N-terminal RING finger, two B-box type ZINC FINGERS, and C-terminal PHD domain. It functions as a transcriptional repressor by associating with Kruppel-association box domain (KRAB domain) transcription factors and has E3-SUMO-ligase activity towards itself and also sumoylates INTERFERON REGULATORY FACTOR-7 to reduce its activity as a transcriptional activator. It can also function as a ubiquitin protein ligase towards TUMOR SUPPRESSOR PROTEIN P53.
| Descriptor ID |
D000076183
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| MeSH Number(s) |
D08.811.464.938.750.782 D12.776.260.703.675 D12.776.930.780.911 D12.776.934.875
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Tripartite Motif-Containing Protein 28".
Below are MeSH descriptors whose meaning is more specific than "Tripartite Motif-Containing Protein 28".
This graph shows the total number of publications written about "Tripartite Motif-Containing Protein 28" by people in this website by year, and whether "Tripartite Motif-Containing Protein 28" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 0 | 1 | 1 | | 2020 | 1 | 0 | 1 | | 2021 | 2 | 0 | 2 |
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Below are the most recent publications written about "Tripartite Motif-Containing Protein 28" by people in Profiles.
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Lin J, Guo D, Liu H, Zhou W, Wang C, M?ller I, Kossenkov AV, Drapkin R, Bitler BG, Helin K, Zhang R. The SETDB1-TRIM28 Complex Suppresses Antitumor Immunity. Cancer Immunol Res. 2021 12; 9(12):1413-1424.
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Agarwal N, Rinaldetti S, Cheikh BB, Zhou Q, Hass EP, Jones RT, Joshi M, LaBarbera DV, Knott SRV, Cech TR, Theodorescu D. TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer. Proc Natl Acad Sci U S A. 2021 09 21; 118(38).
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Bacon CW, Challa A, Hyder U, Shukla A, Borkar AN, Bayo J, Liu J, Wu SY, Chiang CM, Kutateladze TG, D'Orso I. KAP1 Is a Chromatin Reader that Couples Steps of RNA Polymerase II Transcription to Sustain Oncogenic Programs. Mol Cell. 2020 06 18; 78(6):1133-1151.e14.
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Bunch H, Zheng X, Burkholder A, Dillon ST, Motola S, Birrane G, Ebmeier CC, Levine S, Fargo D, Hu G, Taatjes DJ, Calderwood SK. TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause release. Nat Struct Mol Biol. 2014 Oct; 21(10):876-83.
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Cheng B, Ren X, Kerppola TK. KAP1 represses differentiation-inducible genes in embryonic stem cells through cooperative binding with PRC1 and derepresses pluripotency-associated genes. Mol Cell Biol. 2014 Jun; 34(11):2075-91.
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Jeevan-Raj BP, Robert I, Heyer V, Page A, Wang JH, Cammas F, Alt FW, Losson R, Reina-San-Martin B. Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination. J Exp Med. 2011 Aug 01; 208(8):1649-60.
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