 Deubiquitinating Enzyme CYLD
"Deubiquitinating Enzyme CYLD" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A deubiquitinase and tumor-suppressor protein that specifically cleaves LYSINE-63-linked polyubiquitin chains and also has endodeubiquitinase activity. It functions to regulate NF-KAPPA B and WNT SIGNALING PATHWAY activity, contributing to cell survival, proliferation, and differentiation. Mutations in the CYLD gene are associated with cases of FAMILIAL CYLINDROMATOSIS.
| Descriptor ID |
D000074749
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| MeSH Number(s) |
D08.811.037.375 D12.776.624.776.482
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| Concept/Terms |
Deubiquitinating Enzyme CYLD- Deubiquitinating Enzyme CYLD
- CYLD, Deubiquitinating Enzyme
- Cylindromatosis Protein
- Deubiquitinating Enzyme Cylindromatosis
- Cylindromatosis, Deubiquitinating Enzyme
- CYLD Protein
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Below are MeSH descriptors whose meaning is more general than "Deubiquitinating Enzyme CYLD".
Below are MeSH descriptors whose meaning is more specific than "Deubiquitinating Enzyme CYLD".
This graph shows the total number of publications written about "Deubiquitinating Enzyme CYLD" by people in this website by year, and whether "Deubiquitinating Enzyme CYLD" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 0 | 2 | 2 | | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Deubiquitinating Enzyme CYLD" by people in Profiles.
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Mukherjee S, Kumar R, Tsakem Lenou E, Basrur V, Kontoyiannis DL, Ioakeimidis F, Mosialos G, Theiss AL, Flavell RA, Venuprasad K. Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation. Nat Immunol. 2020 06; 21(6):626-635.
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Xu C, He X, Zheng Z, Zhang Z, Wei C, Guan K, Hou L, Zhang B, Zhu L, Cao Y, Zhang Y, Cao Y, Ma S, Wang P, Zhang P, Xu Q, Ling Y, Yang X, Zhong H. Downregulation of microRNA miR-526a by enterovirus inhibits RIG-I-dependent innate immune response. J Virol. 2014 Oct; 88(19):11356-68.
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Thein S, Tao-Cheng JH, Li Y, Bayer KU, Reese TS, Dosemeci A. CaMKII mediates recruitment and activation of the deubiquitinase CYLD at the postsynaptic density. PLoS One. 2014; 9(3):e91312.
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