 Heterochromatin
"Heterochromatin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The portion of chromosome material that remains condensed and is transcriptionally inactive during INTERPHASE.
| Descriptor ID |
D006570
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| MeSH Number(s) |
A11.284.430.106.279.345.190.160.180.383 D12.776.664.224.466 G05.360.160.180.383
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Heterochromatin".
Below are MeSH descriptors whose meaning is more specific than "Heterochromatin".
This graph shows the total number of publications written about "Heterochromatin" by people in this website by year, and whether "Heterochromatin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2008 | 1 | 0 | 1 | | 2009 | 2 | 0 | 2 | | 2010 | 2 | 1 | 3 | | 2011 | 1 | 0 | 1 | | 2012 | 0 | 1 | 1 | | 2013 | 4 | 1 | 5 | | 2015 | 2 | 3 | 5 | | 2016 | 3 | 2 | 5 | | 2018 | 3 | 1 | 4 | | 2019 | 2 | 1 | 3 | | 2020 | 0 | 1 | 1 | | 2021 | 0 | 1 | 1 | | 2022 | 2 | 1 | 3 | | 2023 | 0 | 3 | 3 | | 2024 | 2 | 1 | 3 | | 2025 | 0 | 3 | 3 | | 2026 | 3 | 0 | 3 |
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Below are the most recent publications written about "Heterochromatin" by people in Profiles.
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Ingersoll S, Trouth A, Angel JC, Luo X, Espinoza A, Wen J, Zhu C, Tucker J, Astatike K, Phiel CJ, Sabaawy H, Kutateladze TG, Wu TP, Yao T, Lu C, Ramachandran S, Ren X. Self-clustering of three CBX2 molecules drives PRC2 to promote facultative heterochromatinization of Polycomb target genes. Mol Cell. 2026 Mar 19; 86(6):1015-1031.e16.
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Rosas R, Baracaldo-Lancheros LF, Dykhuizen EC, Musselman CA. Structural landscape of H3K27me3 recognition by protein domains and their potential for inhibition. J Biol Chem. 2026 Apr; 302(4):111344.
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Taylor ER, Proctor B, Vaurs M, Wu G, Mahieu M, Shrestha S, Morrison D, Weatherly L, Brelinsky S, Raghunandan M, Decottignies A, Arnoult N. Local heterochromatin enrichment promotes telomere clustering and PML nuclear body assembly at telomeres. Cell Rep. 2026 Mar 24; 45(3):117004.
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Ebot-Ojong F, Ferraro AR, Yap RE, Kaddar F, Hull-Crew C, Scadden AW, Deaven AM, Klocko AD, Lewis ZA. HISTONE DEACETYLASE-1 is required for epigenome stability in Neurospora crassa. Proc Natl Acad Sci U S A. 2025 Oct 07; 122(40):e2503876122.
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Gaurav N, O'Hara R, Hyder U, Qin W, Her C, Romero H, Kumar A, Marcaida MJ, Singh RK, Hovius R, Selvam K, Liu J, Martire S, Yao Y, Challa A, Dal Peraro M, Fierz B, Kono H, Cardoso MC, Debelouchina GT, Leonhardt H, D'Orso I, Banaszynski LA, Kutateladze TG. The HP1 box of KAP1 organizes HP1a for silencing of endogenous retroviral elements in embryonic stem cells. Nat Commun. 2025 May 31; 16(1):5066.
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Trouth A, Ravichandran K, Gafken PR, Martire S, Boyle GE, Veronezi GMB, La V, Namciu SJ, Banaszynski LA, Sarthy JF, Ramachandran S. The length of the G1 phase is an essential determinant of H3K27me3 landscapes across diverse cell types. PLoS Biol. 2025 Apr; 23(4):e3003119.
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Reckard AT, Pandeya A, Voris JM, Gonzalez Cruz CG, Oluwadare O, Klocko AD. A constitutive heterochromatic region shapes genome organization and impacts gene expression in Neurospora crassa. BMC Genomics. 2024 Dec 20; 25(1):1215.
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Trouth A, Veronezi GMB, Ramachandran S. The impact of cell states on heterochromatin dynamics. Biochem J. 2024 11 06; 481(21):1519-1533.
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Williams JF, Surovtsev IV, Schreiner SM, Chen Z, Raiymbek G, Nguyen H, Hu Y, Biteen JS, Mochrie SGJ, Ragunathan K, King MC. The condensation of HP1a/Swi6 imparts nuclear stiffness. Cell Rep. 2024 07 23; 43(7):114373.
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Scadden AW, Graybill AS, Hull-Crew C, Lundberg TJ, Lande NM, Klocko AD. Histone deacetylation and cytosine methylation compartmentalize heterochromatic regions in the genome organization of Neurospora crassa. Proc Natl Acad Sci U S A. 2023 11 21; 120(47):e2311249120.
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