 DNA Breaks, Double-Stranded
"DNA Breaks, Double-Stranded" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Interruptions in the sugar-phosphate backbone of DNA, across both strands adjacently.
| Descriptor ID |
D053903
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| MeSH Number(s) |
G05.200.210.220
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| Concept/Terms |
DNA Breaks, Double-Stranded- DNA Breaks, Double-Stranded
- Break, Double-Stranded DNA
- Breaks, Double-Stranded DNA
- DNA Break, Double-Stranded
- DNA Breaks, Double Stranded
- Double-Stranded DNA Break
- Double Stranded DNA Break
- Double-Strand DNA Breaks
- Break, Double-Strand DNA
- Breaks, Double-Strand DNA
- DNA Break, Double-Strand
- DNA Breaks, Double-Strand
- Double Strand DNA Breaks
- Double-Strand DNA Break
- Double-Stranded DNA Breaks
- Double Stranded DNA Breaks
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Below are MeSH descriptors whose meaning is more general than "DNA Breaks, Double-Stranded".
Below are MeSH descriptors whose meaning is more specific than "DNA Breaks, Double-Stranded".
This graph shows the total number of publications written about "DNA Breaks, Double-Stranded" by people in this website by year, and whether "DNA Breaks, Double-Stranded" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 4 | 4 | | 2009 | 1 | 1 | 2 | | 2010 | 0 | 3 | 3 | | 2011 | 0 | 1 | 1 | | 2013 | 2 | 0 | 2 | | 2014 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2017 | 1 | 1 | 2 | | 2018 | 0 | 1 | 1 | | 2019 | 2 | 3 | 5 | | 2020 | 3 | 1 | 4 | | 2021 | 1 | 1 | 2 | | 2022 | 1 | 0 | 1 | | 2023 | 3 | 0 | 3 | | 2024 | 1 | 1 | 2 | | 2025 | 2 | 2 | 4 |
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Below are the most recent publications written about "DNA Breaks, Double-Stranded" by people in Profiles.
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Guo Y, Li Z, Parsels LA, Wang Z, Parsels JD, Dalvi A, The S, Hu N, Valvo VM, Doherty R, Peterson E, Wang X, Venkataraman S, Agnihotri S, Venneti S, Wahl DR, Green MD, Lawrence TS, Koschmann C, Morgan MA, Zhang Q. H3K27M diffuse midline glioma is homologous recombination defective and sensitized to radiotherapy and NK cell-mediated antitumor immunity by PARP inhibition. Neuro Oncol. 2025 Sep 17; 27(8):2129-2146.
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Ortega R, Bitler BG, Arnoult N. Multiple functions of PARP1 in the repair of DNA double strand breaks. DNA Repair (Amst). 2025 Aug; 152:103873.
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Jalan M, Brambati A, Shah H, McDermott N, Patel J, Zhu Y, Doymaz A, Wu J, Anderson KS, Gazzo A, Pareja F, Yamaguchi TN, Vougiouklakis T, Ahmed-Seghir S, Steinberg P, Neiman-Golden A, Azeroglu B, Gomez-Aguilar J, da Silva EM, Hussain S, Higginson D, Boutros PC, Riaz N, Reis-Filho JS, Powell SN, Sfeir A. RNA transcripts serve as a template for double-strand break repair in human cells. Nat Commun. 2025 May 10; 16(1):4349.
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Cortázar MA, Jagannathan S. SelectRepair Knockout: Efficient PTC-Free Gene Knockout Through Selectable Homology-Directed DNA Repair. Methods Mol Biol. 2025; 2863:397-417.
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Arnoult N, Cech TR. Telomerase misbehaves after a breakup. Science. 2024 02 16; 383(6684):702-703.
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Affandi T, Haas A, Ohm AM, Wright GM, Black JC, Reyland ME. PKCd Regulates Chromatin Remodeling and DNA Repair through SIRT6. Mol Cancer Res. 2024 02 01; 22(2):181-196.
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Brambati A, Sacco O, Porcella S, Heyza J, Kareh M, Schmidt JC, Sfeir A. RHINO directs MMEJ to repair DNA breaks in mitosis. Science. 2023 08 11; 381(6658):653-660.
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Arnoult N. Meet the authors: Nausica Arnoult. Mol Cell. 2023 05 04; 83(9):1369-1371.
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Fleury H, MacEachern MK, Stiefel CM, Anand R, Sempeck C, Nebenfuehr B, Maurer-Alcalá K, Ball K, Proctor B, Belan O, Taylor E, Ortega R, Dodd B, Weatherly L, Dansoko D, Leung JW, Boulton SJ, Arnoult N. The APE2 nuclease is essential for DNA double-strand break repair by microhomology-mediated end joining. Mol Cell. 2023 05 04; 83(9):1429-1445.e8.
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Johnston R, Mathias B, Crowley SJ, Schmidt HA, White LS, Mosammaparast N, Green AM, Bednarski JJ. Nuclease-independent functions of RAG1 direct distinct DNA damage responses in B cells. EMBO Rep. 2023 01 09; 24(1):e55429.
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