Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Nausica Christine Arnoult

TitleAssistant Professor
InstitutionUniversity of Colorado Boulder
DepartmentBiology-MCD Instruction

    Collapse Research 
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    R01CA266100     (ARNOULT, NAUSICA C.)Dec 1, 2021 - Nov 30, 2026
    NIH
    Deciphering the function of the APE2 nuclease during repair by alternative end-joining and its role in HR-deficient cells
    Role: Principal Investigator
    R35GM143108     (ARNOULT, NAUSICA C.)Aug 1, 2021 - May 31, 2026
    NIH
    Deciphering the role of heterochromatin in telomere function and maintenance mechanisms
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wu G, Taylor E, Youmans DT, Arnoult N, Cech TR. Rapid dynamics allow the low-abundance RTEL1 helicase to promote telomere replication. Nucleic Acids Res. 2025 Feb 27; 53(5). PMID: 40087886.
      View in: PubMed
    2. Nguyen LL, Watson ZL, Ortega R, Woodruff ER, Jordan KR, Iwanaga R, Yamamoto TM, Bailey CA, To F, Lin S, Villagomez FR, Jeong AD, Guntupalli SR, Behbakht K, Gibaja V, Arnoult N, Chuong EB, Bitler BG. EHMT1/2 Inhibition Promotes Regression of Therapy-Resistant Ovarian Cancer Tumors in a CD8 T-cell-Dependent Manner. Mol Cancer Res. 2024 12 03; 22(12):1117-1127. PMID: 39136655.
      View in: PubMed
    3. Nguyen LL, Watson ZL, Ortega R, Woodruff ER, Jordan KR, Iwanaga R, Yamamoto TM, Bailey CA, To F, Jeong AD, Guntupalli SR, Behbakht K, Gibaja V, Arnoult N, Cocozaki A, Chuong EB, Bitler BG. Combining EHMT and PARP Inhibition: A Strategy to Diminish Therapy-Resistant Ovarian Cancer Tumor Growth while Stimulating Immune Activation. Mol Cancer Ther. 2024 Jun 12; OF1-OF16. PMID: 38863225.
      View in: PubMed
    4. Nguyen LL, Watson ZL, Ortega R, Woodruff ER, Jordan KR, Iwanaga R, Yamamoto TM, Bailey CA, To F, Jeong AD, Guntupalli SR, Behbakht K, Gibaja V, Arnoult N, Cocozaki A, Chuong EB, Bitler BG. Combining EHMT and PARP Inhibition: A Strategy to Diminish Therapy-Resistant Ovarian Cancer Tumor Growth while Stimulating Immune Activation. Mol Cancer Ther. 2024 May 08. PMID: 38714351.
      View in: PubMed
    5. Arnoult N, Cech TR. Telomerase misbehaves after a breakup. Science. 2024 02 16; 383(6684):702-703. PMID: 38359118.
      View in: PubMed
    6. Arnoult N. Meet the authors: Nausica Arnoult. Mol Cell. 2023 05 04; 83(9):1369-1371. PMID: 37146567.
      View in: PubMed
    7. Fleury H, MacEachern MK, Stiefel CM, Anand R, Sempeck C, Nebenfuehr B, Maurer-Alcal? K, Ball K, Proctor B, Belan O, Taylor E, Ortega R, Dodd B, Weatherly L, Dansoko D, Leung JW, Boulton SJ, Arnoult N. The APE2 nuclease is essential for DNA double-strand break repair by microhomology-mediated end joining. Mol Cell. 2023 05 04; 83(9):1429-1445.e8. PMID: 37044098.
      View in: PubMed
    8. Nguyen LL, Watson ZL, Ortega R, Woodruff ER, Jordan KR, Iwanaga R, Yamamoto TM, Bailey CA, Jeong AD, Guntupalli SR, Behbakht K, Gbaja V, Arnoult N, Chuong EB, Bitler BG. Combinatory EHMT and PARP inhibition induces an interferon response and a CD8 T cell-dependent tumor regression in PARP inhibitor-resistant models. bioRxiv. 2023 Feb 23. PMID: 36865165.
      View in: PubMed
    9. Viceconte N, Loriot A, Lona Abreu P, Scheibe M, Fradera Sola A, Butter F, De Smet C, Azzalin CM, Arnoult N, Decottignies A. PAR-TERRA is the main contributor to telomeric repeat-containing RNA transcripts in normal and cancer mouse cells. RNA. 2021 01; 27(1):106-121. PMID: 33127860.
      View in: PubMed
    10. Arnoult N, Correia A, Ma J, Merlo A, Garcia-Gomez S, Maric M, Tognetti M, Benner CW, Boulton SJ, Saghatelian A, Karlseder J. Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN. Nature. 2017 09 20; 549(7673):548-552. PMID: 28959974.
      View in: PubMed
    11. Arnoult N, Karlseder J. Complex interactions between the DNA-damage response and mammalian telomeres. Nat Struct Mol Biol. 2015 Nov; 22(11):859-66. PMID: 26581520.
      View in: PubMed
    12. Arnoult N, Karlseder J. ALT telomeres borrow from meiosis to get moving. Cell. 2014 Sep 25; 159(1):11-12. PMID: 25259914.
      View in: PubMed
    13. Boros J, Arnoult N, Stroobant V, Collet JF, Decottignies A. Polycomb repressive complex 2 and H3K27me3 cooperate with H3K9 methylation to maintain heterochromatin protein 1a at chromatin. Mol Cell Biol. 2014 Oct 01; 34(19):3662-74. PMID: 25047840.
      View in: PubMed
    14. Episkopou H, Draskovic I, Van Beneden A, Tilman G, Mattiussi M, Gobin M, Arnoult N, Londo?o-Vallejo A, Decottignies A. Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin. Nucleic Acids Res. 2014 Apr; 42(7):4391-405. PMID: 24500201.
      View in: PubMed
    15. O'Sullivan RJ, Arnoult N, Lackner DH, Oganesian L, Haggblom C, Corpet A, Almouzni G, Karlseder J. Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1. Nat Struct Mol Biol. 2014 Feb; 21(2):167-74. PMID: 24413054.
      View in: PubMed
    16. Scheibe M, Arnoult N, Kappei D, Buchholz F, Decottignies A, Butter F, Mann M. Quantitative interaction screen of telomeric repeat-containing RNA reveals novel TERRA regulators. Genome Res. 2013 Dec; 23(12):2149-57. PMID: 23921659.
      View in: PubMed
    17. Van Beneden A, Arnoult N, Decottignies A. Telomeric RNA expression: length matters. Front Oncol. 2013; 3:178. PMID: 23847766.
      View in: PubMed
    18. Novo C, Arnoult N, Bordes WY, Castro-Vega L, Gibaud A, Dutrillaux B, Bacchetti S, Londo?o-Vallejo A. The heterochromatic chromosome caps in great apes impact telomere metabolism. Nucleic Acids Res. 2013 May; 41(9):4792-801. PMID: 23519615.
      View in: PubMed
    19. Arnoult N, Van Beneden A, Decottignies A. Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1a. Nat Struct Mol Biol. 2012 Sep; 19(9):948-56. PMID: 22922742.
      View in: PubMed
    20. Tilman G, Arnoult N, Lenglez S, Van Beneden A, Loriot A, De Smet C, Decottignies A. Cancer-linked satellite 2 DNA hypomethylation does not regulate Sat2 non-coding RNA expression and is initiated by heat shock pathway activation. Epigenetics. 2012 Aug; 7(8):903-13. PMID: 22722874.
      View in: PubMed
    21. Arnoult N, Schluth-Bolard C, Letessier A, Drascovic I, Bouarich-Bourimi R, Campisi J, Kim SH, Boussouar A, Ottaviani A, Magdinier F, Gilson E, Londo?o-Vallejo A. Replication timing of human telomeres is chromosome arm-specific, influenced by subtelomeric structures and connected to nuclear localization. PLoS Genet. 2010 Apr 22; 6(4):e1000920. PMID: 20421929.
      View in: PubMed
    22. Arnoult N, Saintome C, Ourliac-Garnier I, Riou JF, Londo?o-Vallejo A. Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN. Genes Dev. 2009 Dec 15; 23(24):2915-24. PMID: 20008939.
      View in: PubMed
    23. Draskovic I, Arnoult N, Steiner V, Bacchetti S, Lomonte P, Londo?o-Vallejo A. Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):15726-31. PMID: 19717459.
      View in: PubMed
    24. Tilman G, Loriot A, Van Beneden A, Arnoult N, Londo?o-Vallejo JA, De Smet C, Decottignies A. Subtelomeric DNA hypomethylation is not required for telomeric sister chromatid exchanges in ALT cells. Oncogene. 2009 Apr 09; 28(14):1682-93. PMID: 19252523.
      View in: PubMed
    25. Arnoult N, Shin-Ya K, Londo?o-Vallejo JA. Studying telomere replication by Q-CO-FISH: the effect of telomestatin, a potent G-quadruplex ligand. Cytogenet Genome Res. 2008; 122(3-4):229-36. PMID: 19188691.
      View in: PubMed
    26. Courbet S, Gay S, Arnoult N, Wronka G, Anglana M, Brison O, Debatisse M. Replication fork movement sets chromatin loop size and origin choice in mammalian cells. Nature. 2008 Sep 25; 455(7212):557-60. PMID: 18716622.
      View in: PubMed
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