Pyrin
"Pyrin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tripartite motif protein that consists of an N-terminal pyrin domain, a central coiled-coil region and B-box type ZINC FINGER, and C-terminal regions that mediate homotrimerization and interactions with other proteins (the B30.2/SPRY DOMAIN). It is expressed primarily by mature GRANULOCYTES and associates with the cytoskeleton in the perinuclear area as well as AUTOPHAGOSOMES, where it co-ordinates the assembly of AUTOPHAGY-RELATED PROTEINS and degradation of INFLAMMASOME components. It functions in INNATE IMMUNITY and INFLAMMATION; mutations in the Pyrin protein (MEFV) gene are associated with FAMILIAL MEDITERRANEAN FEVER.
| Descriptor ID |
D000071198
|
| MeSH Number(s) |
D12.776.220.909 D12.776.934.750
|
| Concept/Terms |
Pyrin- Pyrin
- MEFV Protein
- TRIM20 Protein
- Mediterranean Fever Protein
- Marenostrin
|
Below are MeSH descriptors whose meaning is more general than "Pyrin".
Below are MeSH descriptors whose meaning is more specific than "Pyrin".
This graph shows the total number of publications written about "Pyrin" by people in this website by year, and whether "Pyrin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pyrin" by people in Profiles.
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Keller L, Rabinovitch N. Post COVID recurrent fever in children with polymorphisms in the innate immunity regulator, pyrin; MEFV gene. J Allergy Clin Immunol Pract. 2023 06; 11(6):1943-1944.
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Aubert DF, Xu H, Yang J, Shi X, Gao W, Li L, Bisaro F, Chen S, Valvano MA, Shao F. A Burkholderia Type VI Effector Deamidates Rho GTPases to Activate the Pyrin Inflammasome and Trigger Inflammation. Cell Host Microbe. 2016 May 11; 19(5):664-74.