 Proto-Oncogene Proteins c-akt
"Proto-Oncogene Proteins c-akt" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Protein-serine-threonine kinases that contain PLECKSTRIN HOMOLOGY DOMAINS and are activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. They play a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.
| Descriptor ID |
D051057
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| MeSH Number(s) |
D08.811.913.696.620.682.700.755 D12.776.476.565 D12.776.624.664.700.168
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| Concept/Terms |
Proto-Oncogene Proteins c-akt- Proto-Oncogene Proteins c-akt
- Proto Oncogene Proteins c akt
- c-akt, Proto-Oncogene Proteins
- Protein Kinase B
- Proto-Oncogene Protein RAC
- Proto Oncogene Protein RAC
- RAC, Proto-Oncogene Protein
- Proto-Oncogene Protein Akt
- Akt, Proto-Oncogene Protein
- Proto Oncogene Protein Akt
- Rac Protein Kinase
- akt Proto-Oncogene Protein
- Protein, akt Proto-Oncogene
- Proto-Oncogene Protein, akt
- akt Proto Oncogene Protein
- RAC-PK Protein
- RAC PK Protein
- Related to A and C-Protein
- Related to A and C Protein
- c-akt Proto-Oncogene Protein
- Protein, c-akt Proto-Oncogene
- Proto-Oncogene Protein, c-akt
- c akt Proto Oncogene Protein
- c-akt Protein
- Protein-Serine-Threonine Kinase (Rac)
Proto-Oncogene Proteins c-akt1- Proto-Oncogene Proteins c-akt1
- Proteins c-akt1, Proto-Oncogene
- Proto Oncogene Proteins c akt1
- c-akt1, Proto-Oncogene Proteins
- AKT1 Protein Kinase
- Rac-PK alpha Protein
- Rac PK alpha Protein
- alpha Protein, Rac-PK
- Protein Kinase B alpha
- Akt-alpha Protein
- Akt alpha Protein
Proto-Oncogene Proteins c-akt2- Proto-Oncogene Proteins c-akt2
- Proteins c-akt2, Proto-Oncogene
- Proto Oncogene Proteins c akt2
- c-akt2, Proto-Oncogene Proteins
- Protein Kinase B beta
- Rac-PK beta Protein
- Rac PK beta Protein
- AKT2 Protein Kinase
- Akt-beta Protein
- Akt beta Protein
Proto-Oncogene Proteins c-akt3- Proto-Oncogene Proteins c-akt3
- Proteins c-akt3, Proto-Oncogene
- Proto Oncogene Proteins c akt3
- c-akt3, Proto-Oncogene Proteins
- Akt-gamma Protein
- Akt gamma Protein
- AKT3 Protein Kinase
- Protein Kinase B gamma
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Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-akt".
Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-akt".
This graph shows the total number of publications written about "Proto-Oncogene Proteins c-akt" by people in this website by year, and whether "Proto-Oncogene Proteins c-akt" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 2 | 2 | | 2001 | 0 | 2 | 2 | | 2002 | 0 | 6 | 6 | | 2003 | 0 | 5 | 5 | | 2004 | 0 | 12 | 12 | | 2005 | 0 | 6 | 6 | | 2006 | 1 | 9 | 10 | | 2007 | 1 | 5 | 6 | | 2008 | 6 | 7 | 13 | | 2009 | 3 | 5 | 8 | | 2010 | 5 | 8 | 13 | | 2011 | 3 | 8 | 11 | | 2012 | 2 | 6 | 8 | | 2013 | 0 | 7 | 7 | | 2014 | 4 | 10 | 14 | | 2015 | 3 | 12 | 15 | | 2016 | 2 | 8 | 10 | | 2017 | 8 | 4 | 12 | | 2018 | 1 | 3 | 4 | | 2019 | 3 | 3 | 6 | | 2020 | 3 | 3 | 6 | | 2021 | 1 | 1 | 2 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Proto-Oncogene Proteins c-akt" by people in Profiles.
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Ghosh JC, Perego M, Agarwal E, Bertolini I, Wang Y, Goldman AR, Tang HY, Kossenkov AV, Landis CJ, Languino LR, Plow EF, Morotti A, Ottobrini L, Locatelli M, Speicher DW, Caino MC, Cassel J, Salvino JM, Robert ME, Vaira V, Altieri DC. Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability. Proc Natl Acad Sci U S A. 2022 02 22; 119(8).
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Rutherford TR, Elder AM, Lyons TR. Anoikis resistance in mammary epithelial cells is mediated by semaphorin 7a. Cell Death Dis. 2021 09 24; 12(10):872.
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Anson KJ, Corbet GA, Palmer AE. Zn2+ influx activates ERK and Akt signaling pathways. Proc Natl Acad Sci U S A. 2021 03 16; 118(11).
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Wong H, Levenga J, LaPlante L, Keller B, Cooper-Sansone A, Borski C, Milstead R, Ehringer M, Hoeffer C. Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders. Elife. 2020 12 16; 9.
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Palumbo S, Paterson C, Yang F, Hood VL, Law AJ. PKBß/AKT2 deficiency impacts brain mTOR signaling, prefrontal cortical physiology, hippocampal plasticity and select murine behaviors. Mol Psychiatry. 2021 02; 26(2):411-428.
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Northey JJ, Barrett AS, Acerbi I, Hayward MK, Talamantes S, Dean IS, Mouw JK, Ponik SM, Lakins JN, Huang PJ, Wu J, Shi Q, Samson S, Keely PJ, Mukhtar RA, Liphardt JT, Shepherd JA, Hwang ES, Chen YY, Hansen KC, Littlepage LE, Weaver VM. Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217. J Clin Invest. 2020 11 02; 130(11):5721-5737.
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Liao P, Song K, Zhu Z, Liu Z, Zhang W, Li W, Hu J, Hu Q, Chen C, Chen B, McLeod HL, Pei H, Chen L, He Y. Propranolol Suppresses the Growth of Colorectal Cancer Through Simultaneously Activating Autologous CD8+ T Cells and Inhibiting Tumor AKT/MAPK Pathway. Clin Pharmacol Ther. 2020 09; 108(3):606-615.
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Yao Q, The E, Ao L, Zhai Y, Osterholt MK, Fullerton DA, Meng X. TLR4 Stimulation Promotes Human AVIC Fibrogenic Activity through Upregulation of Neurotrophin 3 Production. Int J Mol Sci. 2020 Feb 14; 21(4).
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Strassheim D, Karoor V, Nijmeh H, Weston P, Lapel M, Schaack J, Sullivan T, Dempsey EC, Stenmark KR, Gerasimovskaya E. c-Jun, Foxo3a, and c-Myc Transcription Factors are Key Regulators of ATP-Mediated Angiogenic Responses in Pulmonary Artery Vasa Vasorum Endothelial Cells. Cells. 2020 02 11; 9(2).
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Kosamo S, Hisert KB, Dmyterko V, Nguyen C, Black RA, Holden TD, Radella F, Cotten PA, Goss CH, Aitken ML, Wurfel MM. Strong toll-like receptor responses in cystic fibrosis patients are associated with higher lung function. J Cyst Fibros. 2020 07; 19(4):608-613.
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