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Charles Albert Hoeffer

TitleAssociate Professor
InstitutionUniversity of Colorado Boulder
DepartmentInstitute for Behav Genetics
    Other Positions
    TitleAssociate Professor
    InstitutionUniversity of Colorado Boulder
    DepartmentIntegrative Physiology


    Collapse Research 
    Collapse research activities and funding
    R01AG085307     (LINK, CHRISTOPHER D.)Jul 1, 2024 - Mar 31, 2029
    NIH
    Double-stranded RNA in neuronal cell death in Alzheimer's and related neurodegenerative diseases
    Role: Co-Principal Investigator
    R01AG083268     (HOEFFER, CHARLES A)Sep 15, 2023 - May 31, 2028
    NIH
    Sleep abnormalities in Down Syndrome-related Alzheimer's disease
    Role: Principal Investigator
    R33DA055781     (EHRINGER, MARISSA A)Sep 15, 2022 - Aug 31, 2027
    NIH
    Role of glial expression in nicotine behaviors for genes identified through human GWAS
    Role: Co-Principal Investigator
    R21DA055781     (EHRINGER, MARISSA A)Sep 15, 2022 - Aug 31, 2024
    NIH
    Role of glial expression in nicotine behaviors for genes identified through human GWAS
    Role: Co-Principal Investigator
    R01AG064465     (OPP, MARK R)Aug 1, 2019 - Apr 30, 2024
    NIH/NIA
    Sleep Disruption and Alzheimer's Disease Pathology
    Role: Co-Principal Investigator
    RF1AG064465     (OPP, MARK R)Aug 1, 2019 - Mar 31, 2024
    NIH
    Sleep Disruption and Alzheimer's Disease Pathology
    Role: Co-Principal Investigator
    R01NS086933     (HOEFFER, CHARLES A)Apr 1, 2015 - Mar 31, 2021
    NIH
    Akt regulation of synaptic plasticity and behavior
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Mehrhoff EA, Booher WC, Hutchinson J, Schumacher G, Borski C, Lowry CA, Hoeffer CA, Ehringer MA. Diazepam effects on anxiety-related defensive behavior of male and female high and low open-field activity inbred mouse strains. Physiol Behav. 2023 Nov 01; 271:114343. PMID: 37689380.
      View in: PubMed
    2. Brasher MS, Mize TJ, Thomas AL, Hoeffer CA, Ehringer MA, Evans LM. Testing associations between human anxiety and genes previously implicated by mouse anxiety models. Genes Brain Behav. 2023 12; 22(6):e12851. PMID: 37259642.
      View in: PubMed
    3. Evans LM, Arehart CH, Grotzinger AD, Mize TJ, Brasher MS, Stitzel JA, Ehringer MA, Hoeffer CA. Transcriptome-wide gene-gene interaction associations elucidate pathways and functional enrichment of complex traits. PLoS Genet. 2023 05; 19(5):e1010693. PMID: 37216417.
      View in: PubMed
    4. Milstead RA, Link CD, Xu Z, Hoeffer CA. TDP-43 knockdown in mouse model of ALS leads to dsRNA deposition, gliosis, and neurodegeneration in the spinal cord. Cereb Cortex. 2023 05 09; 33(10):5808-5816. PMID: 36443249.
      View in: PubMed
    5. Sharma S, Borski C, Hanson J, Garcia MA, Link CD, Hoeffer C, Chatterjee A, Nagpal P. Identifying an Optimal Neuroinflammation Treatment Using a Nanoligomer Discovery Engine. ACS Chem Neurosci. 2022 12 07; 13(23):3247-3256. PMID: 36410860.
      View in: PubMed
    6. Wong H, Buck JM, Borski C, Pafford JT, Keller BN, Milstead RA, Hanson JL, Stitzel JA, Hoeffer CA. RCAN1 knockout and overexpression recapitulate an ensemble of rest-activity and circadian disruptions characteristic of Down syndrome, Alzheimer's disease, and normative aging. J Neurodev Disord. 2022 05 24; 14(1):33. PMID: 35610565.
      View in: PubMed
    7. Colbert SMC, Funkhouser SA, Johnson EC, Morrison CL, Hoeffer CA, Friedman NP, Ehringer MA, Evans LM. Novel characterization of the multivariate genetic architecture of internalizing psychopathology and alcohol use. Am J Med Genet B Neuropsychiatr Genet. 2021 09; 186(6):353-366. PMID: 34569141.
      View in: PubMed
    8. Levenga J, Wong H, Milstead R, LaPlante L, Hoeffer CA. Immunohistological Examination of AKT Isoforms in the Brain: Cell-Type Specificity That May Underlie AKT's Role in Complex Brain Disorders and Neurological Disease. Cereb Cortex Commun. 2021; 2(2):tgab036. PMID: 34296180.
      View in: PubMed
    9. Gindina S, Botsford B, Cowansage K, LeDoux J, Klann E, Hoeffer C, Ostroff L. Upregulation of eIF4E, but not other translation initiation factors, in dendritic spines during memory formation. J Comp Neurol. 2021 08 01; 529(11):3112-3126. PMID: 33864263.
      View in: PubMed
    10. Wong H, Levenga J, LaPlante L, Keller B, Cooper-Sansone A, Borski C, Milstead R, Ehringer M, Hoeffer C. Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders. Elife. 2020 12 16; 9. PMID: 33325370.
      View in: PubMed
    11. Evans LM, Johnson EC, Melroy-Greif WE, Hewitt JK, Hoeffer CA, Keller MC, Saba LM, Stitzel JA, Ehringer MA. The Role of A Priori-Identified Addiction and Smoking Gene Sets in Smoking Behaviors. Nicotine Tob Res. 2020 07 16; 22(8):1310-1315. PMID: 31930296.
      View in: PubMed
    12. Levenga J, Peterson DJ, Cain P, Hoeffer CA. Sleep Behavior and EEG Oscillations in Aged Dp(16)1Yey/+ Mice: A Down Syndrome Model. Neuroscience. 2018 04 15; 376:117-126. PMID: 29454635.
      View in: PubMed
    13. Levenga J, Wong H, Milstead RA, Keller BN, LaPlante LE, Hoeffer CA. AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity. Elife. 2017 11 27; 6. PMID: 29173281.
      View in: PubMed
    14. Wong H, Hoeffer C. Maternal IL-17A in autism. Exp Neurol. 2018 01; 299(Pt A):228-240. PMID: 28455196.
      View in: PubMed
    15. Koukouli F, Rooy M, Tziotis D, Sailor KA, O'Neill HC, Levenga J, Witte M, Nilges M, Changeux JP, Hoeffer CA, Stitzel JA, Gutkin BS, DiGregorio DA, Maskos U. Nicotine reverses hypofrontality in animal models of addiction and schizophrenia. Nat Med. 2017 Mar; 23(3):347-354. PMID: 28112735.
      View in: PubMed
    16. Ostroff LE, Botsford B, Gindina S, Cowansage KK, LeDoux JE, Klann E, Hoeffer C. Accumulation of Polyribosomes in Dendritic Spine Heads, But Not Bases and Necks, during Memory Consolidation Depends on Cap-Dependent Translation Initiation. J Neurosci. 2017 02 15; 37(7):1862-1872. PMID: 28087764.
      View in: PubMed
    17. Congdon EE, Lin Y, Rajamohamedsait HB, Shamir DB, Krishnaswamy S, Rajamohamedsait WJ, Rasool S, Gonzalez V, Levenga J, Gu J, Hoeffer C, Sigurdsson EM. Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy. Mol Neurodegener. 2016 08 30; 11(1):62. PMID: 27578006.
      View in: PubMed
    18. Choi GB, Yim YS, Wong H, Kim S, Kim H, Kim SV, Hoeffer CA, Littman DR, Huh JR. The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring. Science. 2016 Feb 26; 351(6276):933-9. PMID: 26822608.
      View in: PubMed
    19. Wong H, Levenga J, Cain P, Rothermel B, Klann E, Hoeffer C. RCAN1 overexpression promotes age-dependent mitochondrial dysregulation related to neurodegeneration in Alzheimer's disease. Acta Neuropathol. 2015 Dec; 130(6):829-43. PMID: 26497675.
      View in: PubMed
    20. Karayannis T, Au E, Patel JC, Kruglikov I, Markx S, Delorme R, H?ron D, Salomon D, Glessner J, Restituito S, Gordon A, Rodriguez-Murillo L, Roy NC, Gogos JA, Rudy B, Rice ME, Karayiorgou M, Hakonarson H, Keren B, Huguet G, Bourgeron T, Hoeffer C, Tsien RW, Peles E, Fishell G. Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission. Nature. 2014 Jul 10; 511(7508):236-40. PMID: 24870235.
      View in: PubMed
    21. Wincott CM, Abera S, Vunck SA, Tirko N, Choi Y, Titcombe RF, Antoine SO, Tukey DS, DeVito LM, Hofmann F, Hoeffer CA, Ziff EB. cGMP-dependent protein kinase type II knockout mice exhibit working memory impairments, decreased repetitive behavior, and increased anxiety-like traits. Neurobiol Learn Mem. 2014 Oct; 114:32-9. PMID: 24752151.
      View in: PubMed
    22. Trinh MA, Ma T, Kaphzan H, Bhattacharya A, Antion MD, Cavener DR, Hoeffer CA, Klann E. The eIF2a kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression. Learn Mem. 2014 Apr 16; 21(5):298-304. PMID: 24741110.
      View in: PubMed
    23. Bowling H, Zhang G, Bhattacharya A, P?rez-Cuesta LM, Deinhardt K, Hoeffer CA, Neubert TA, Gan WB, Klann E, Chao MV. Antipsychotics activate mTORC1-dependent translation to enhance neuronal morphological complexity. Sci Signal. 2014 Jan 14; 7(308):ra4. PMID: 24425786.
      View in: PubMed
    24. Hoeffer CA, Wong H, Cain P, Levenga J, Cowansage KK, Choi Y, Davy C, Majmundar N, McMillan DR, Rothermel BA, Klann E. Regulator of calcineurin 1 modulates expression of innate anxiety and anxiogenic responses to selective serotonin reuptake inhibitor treatment. J Neurosci. 2013 Oct 23; 33(43):16930-44. PMID: 24155299.
      View in: PubMed
    25. Levenga J, Krishnamurthy P, Rajamohamedsait H, Wong H, Franke TF, Cain P, Sigurdsson EM, Hoeffer CA. Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments. Acta Neuropathol Commun. 2013 Jul 11; 1:34. PMID: 24252661.
      View in: PubMed
    26. Wincott CM, Kim S, Titcombe RF, Tukey DS, Girma HK, Pick JE, Devito LM, Hofmann F, Hoeffer C, Ziff EB. Spatial memory deficits and motor coordination facilitation in cGMP-dependent protein kinase type II-deficient mice. Neurobiol Learn Mem. 2013 Jan; 99:32-7. PMID: 23103773.
      View in: PubMed
    27. Hoeffer CA, Santini E, Ma T, Arnold EC, Whelan AM, Wong H, Pierre P, Pelletier J, Klann E. Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation. J Neurophysiol. 2013 Jan; 109(1):68-76. PMID: 23054596.
      View in: PubMed
    28. Rakowski-Anderson T, Wong H, Rothermel B, Cain P, Lavilla C, Pullium JK, Hoeffer C. Fecal corticosterone levels in RCAN1 mutant mice. Comp Med. 2012 Apr; 62(2):87-94. PMID: 22546913.
      View in: PubMed
    29. Hoeffer CA, Sanchez E, Hagerman RJ, Mu Y, Nguyen DV, Wong H, Whelan AM, Zukin RS, Klann E, Tassone F. Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome. Genes Brain Behav. 2012 Apr; 11(3):332-41. PMID: 22268788.
      View in: PubMed
    30. Valjent E, Bertran-Gonzalez J, Bowling H, Lopez S, Santini E, Matamales M, Bonito-Oliva A, Herv? D, Hoeffer C, Klann E, Girault JA, Fisone G. Haloperidol regulates the state of phosphorylation of ribosomal protein S6 via activation of PKA and phosphorylation of DARPP-32. Neuropsychopharmacology. 2011 Nov; 36(12):2561-70. PMID: 21814187.
      View in: PubMed
    31. Ma T, Hoeffer CA, Wong H, Massaad CA, Zhou P, Iadecola C, Murphy MP, Pautler RG, Klann E. Amyloid ?-induced impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide. J Neurosci. 2011 Apr 13; 31(15):5589-95. PMID: 21490199.
      View in: PubMed
    32. Connor SA, Hoeffer CA, Klann E, Nguyen PV. Fragile X mental retardation protein regulates heterosynaptic plasticity in the hippocampus. Learn Mem. 2011; 18(4):207-20. PMID: 21430043.
      View in: PubMed
    33. Hoeffer CA, Cowansage KK, Arnold EC, Banko JL, Moerke NJ, Rodriguez R, Schmidt EK, Klosi E, Chorev M, Lloyd RE, Pierre P, Wagner G, LeDoux JE, Klann E. Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation. Proc Natl Acad Sci U S A. 2011 Feb 22; 108(8):3383-8. PMID: 21289279.
      View in: PubMed
    34. Ma T, Hoeffer CA, Capetillo-Zarate E, Yu F, Wong H, Lin MT, Tampellini D, Klann E, Blitzer RD, Gouras GK. Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease. PLoS One. 2010 Sep 20; 5(9). PMID: 20862226.
      View in: PubMed
    35. Suvrathan A, Hoeffer CA, Wong H, Klann E, Chattarji S. Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome. Proc Natl Acad Sci U S A. 2010 Jun 22; 107(25):11591-6. PMID: 20534533.
      View in: PubMed
    36. Sharma A, Hoeffer CA, Takayasu Y, Miyawaki T, McBride SM, Klann E, Zukin RS. Dysregulation of mTOR signaling in fragile X syndrome. J Neurosci. 2010 Jan 13; 30(2):694-702. PMID: 20071534.
      View in: PubMed
    37. Hoeffer CA, Klann E. mTOR signaling: at the crossroads of plasticity, memory and disease. Trends Neurosci. 2010 Feb; 33(2):67-75. PMID: 19963289.
      View in: PubMed
    38. Hoeffer CA, Tang W, Wong H, Santillan A, Patterson RJ, Martinez LA, Tejada-Simon MV, Paylor R, Hamilton SL, Klann E. Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior. Neuron. 2008 Dec 10; 60(5):832-45. PMID: 19081378.
      View in: PubMed
    39. Antion MD, Hou L, Wong H, Hoeffer CA, Klann E. mGluR-dependent long-term depression is associated with increased phosphorylation of S6 and synthesis of elongation factor 1A but remains expressed in S6K-deficient mice. Mol Cell Biol. 2008 May; 28(9):2996-3007. PMID: 18316404.
      View in: PubMed
    40. Antion MD, Merhav M, Hoeffer CA, Reis G, Kozma SC, Thomas G, Schuman EM, Rosenblum K, Klann E. Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity. Learn Mem. 2008 Jan; 15(1):29-38. PMID: 18174371.
      View in: PubMed
    41. Hoeffer CA, Dey A, Sachan N, Wong H, Patterson RJ, Shelton JM, Richardson JA, Klann E, Rothermel BA. The Down syndrome critical region protein RCAN1 regulates long-term potentiation and memory via inhibition of phosphatase signaling. J Neurosci. 2007 Nov 28; 27(48):13161-72. PMID: 18045910.
      View in: PubMed
    42. Hoeffer CA, Klann E. Switching gears: translational mastery of transcription during memory formation. Neuron. 2007 Apr 19; 54(2):186-9. PMID: 17442240.
      View in: PubMed
    43. Kishida KT, Hoeffer CA, Hu D, Pao M, Holland SM, Klann E. Synaptic plasticity deficits and mild memory impairments in mouse models of chronic granulomatous disease. Mol Cell Biol. 2006 Aug; 26(15):5908-20. PMID: 16847341.
      View in: PubMed
    44. Hoeffer CA, Sanyal S, Ramaswami M. Acute induction of conserved synaptic signaling pathways in Drosophila melanogaster. J Neurosci. 2003 Jul 16; 23(15):6362-72. PMID: 12867522.
      View in: PubMed
    45. Yamauchi Y, Hoeffer C, Yamamoto A, Takeda H, Ishihara R, Maekawa H, Sato R, Su-Il S, Sumida M, Wells MA, Tsuchida K. cDNA and deduced amino acid sequences of apolipophorin-IIIs from Bombyx mori and Bombyx mandarina. Arch Insect Biochem Physiol. 2000 Jan; 43(1):16-21. PMID: 10613959.
      View in: PubMed
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