 A Kinase Anchor Proteins
"A Kinase Anchor Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A structurally-diverse family of intracellular-signaling adaptor proteins that selectively tether specific protein kinase A subtypes to distinct subcellular sites. They play a role in focusing the PROTEIN KINASE A activity toward relevant substrates. Over fifty members of this family exist, most of which bind specifically to regulatory subunits of CYCLIC AMP-DEPENDENT PROTEIN KINASE TYPE II such as CAMP PROTEIN KINASE RIIALPHA or CAMP PROTEIN KINASE RIIBETA.
| Descriptor ID |
D054758
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| MeSH Number(s) |
D12.644.360.024.065 D12.776.157.057.003 D12.776.476.024.069
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| Concept/Terms |
A Kinase Anchor Proteins- A Kinase Anchor Proteins
- Protein Kinase A Anchor Proteins
- A-Kinase Anchor Proteins
- Anchor Proteins, A-Kinase
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Below are MeSH descriptors whose meaning is more general than "A Kinase Anchor Proteins".
Below are MeSH descriptors whose meaning is more specific than "A Kinase Anchor Proteins".
This graph shows the total number of publications written about "A Kinase Anchor Proteins" by people in this website by year, and whether "A Kinase Anchor Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1996 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 2 | 2 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 2 | 2 | | 2007 | 0 | 2 | 2 | | 2009 | 1 | 1 | 2 | | 2010 | 1 | 0 | 1 | | 2011 | 2 | 1 | 3 | | 2012 | 5 | 1 | 6 | | 2013 | 3 | 0 | 3 | | 2014 | 2 | 0 | 2 | | 2015 | 3 | 0 | 3 | | 2016 | 1 | 0 | 1 | | 2017 | 5 | 0 | 5 | | 2018 | 3 | 1 | 4 | | 2019 | 1 | 0 | 1 | | 2021 | 2 | 0 | 2 | | 2022 | 0 | 1 | 1 | | 2024 | 3 | 1 | 4 | | 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "A Kinase Anchor Proteins" by people in Profiles.
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Koek L, Jo HN, Kennedy MJ, Dell'Acqua ML. Anchored kinase and phosphatase signaling networks in amyloid ß-induced synaptic dysfunction. Mol Pharmacol. 2026 08; 108(8):100141.
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Prikhodko O, Freund RK, Sullivan E, Kennedy MJ, Dell'Acqua ML. Amyloid-ß Causes NMDA Receptor Dysfunction and Dendritic Spine Loss through mGluR1 and AKAP150-Anchored Calcineurin Signaling. J Neurosci. 2024 09 11; 44(37).
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Mouery RD, Lukasik K, Hsu C, Bonacci T, Bolhuis DL, Wang X, Mills CA, Toomer ED, Canterbury OG, Robertson KC, Branigan TB, Brown NG, Herring LE, Gupton SL, Emanuele MJ. Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton. Cell Rep. 2024 08 27; 43(8):114510.
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Robinson EL, Tharp CA, Bagchi RA, McKinsey TA. Gravi-D peptide disrupts HDAC11 association with an AKAP to stimulate adipocyte thermogenic signaling. J Clin Invest. 2024 05 01; 134(9).
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Simmons SC, Flerlage WJ, Langlois LD, Shepard RD, Bouslog C, Thomas EH, Gouty KM, Sanderson JL, Gouty S, Cox BM, Dell'Acqua ML, Nugent FS. AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula. Commun Biol. 2024 03 20; 7(1):345.
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Palmer DS, Howrigan DP, Chapman SB, Adolfsson R, Bass N, Blackwood D, Boks MPM, Chen CY, Churchhouse C, Corvin AP, Craddock N, Curtis D, Di Florio A, Dickerson F, Freimer NB, Goes FS, Jia X, Jones I, Jones L, Jonsson L, Kahn RS, Landén M, Locke AE, McIntosh AM, McQuillin A, Morris DW, O'Donovan MC, Ophoff RA, Owen MJ, Pedersen NL, Posthuma D, Reif A, Risch N, Schaefer C, Scott L, Singh T, Smoller JW, Solomonson M, Clair DS, Stahl EA, Vreeker A, Walters JTR, Wang W, Watts NA, Yolken R, Zandi PP, Neale BM. Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia. Nat Genet. 2022 05; 54(5):541-547.
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Sanderson JL, Freund RK, Gorski JA, Dell'Acqua ML. ß-Amyloid disruption of LTP/LTD balance is mediated by AKAP150-anchored PKA and Calcineurin regulation of Ca2+-permeable AMPA receptors. Cell Rep. 2021 10 05; 37(1):109786.
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Cochrane VA, Yang Z, Dell'Acqua ML, Shyng SL. AKAP79/150 coordinates leptin-induced PKA signaling to regulate KATP channel trafficking in pancreatic ß-cells. J Biol Chem. 2021 Jan-Jun; 296:100442.
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Murphy JG, Crosby KC, Dittmer PJ, Sather WA, Dell'Acqua ML. AKAP79/150 recruits the transcription factor NFAT to regulate signaling to the nucleus by neuronal L-type Ca2+ channels. Mol Biol Cell. 2019 07 01; 30(14):1743-1756.
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Purkey AM, Woolfrey KM, Crosby KC, Stich DG, Chick WS, Aoto J, Dell'Acqua ML. AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP. Cell Rep. 2018 10 23; 25(4):974-987.e4.
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