 A Kinase Anchor Proteins
"A Kinase Anchor Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A structurally-diverse family of intracellular-signaling adaptor proteins that selectively tether specific protein kinase A subtypes to distinct subcellular sites. They play a role in focusing the PROTEIN KINASE A activity toward relevant substrates. Over fifty members of this family exist, most of which bind specifically to regulatory subunits of CYCLIC AMP-DEPENDENT PROTEIN KINASE TYPE II such as CAMP PROTEIN KINASE RIIALPHA or CAMP PROTEIN KINASE RIIBETA.
| Descriptor ID |
D054758
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| MeSH Number(s) |
D12.644.360.024.065 D12.776.157.057.003 D12.776.476.024.069
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| Concept/Terms |
A Kinase Anchor Proteins- A Kinase Anchor Proteins
- Protein Kinase A Anchor Proteins
- A-Kinase Anchor Proteins
- Anchor Proteins, A-Kinase
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Below are MeSH descriptors whose meaning is more general than "A Kinase Anchor Proteins".
Below are MeSH descriptors whose meaning is more specific than "A Kinase Anchor Proteins".
This graph shows the total number of publications written about "A Kinase Anchor Proteins" by people in this website by year, and whether "A Kinase Anchor Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1996 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 2 | 2 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 2 | 2 | | 2007 | 0 | 2 | 2 | | 2008 | 1 | 0 | 1 | | 2009 | 1 | 1 | 2 | | 2010 | 1 | 0 | 1 | | 2011 | 2 | 1 | 3 | | 2012 | 5 | 1 | 6 | | 2013 | 2 | 0 | 2 | | 2014 | 2 | 0 | 2 | | 2015 | 3 | 0 | 3 | | 2016 | 1 | 0 | 1 | | 2017 | 5 | 0 | 5 | | 2018 | 2 | 1 | 3 | | 2019 | 1 | 0 | 1 | | 2021 | 2 | 0 | 2 | | 2024 | 2 | 1 | 3 |
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Below are the most recent publications written about "A Kinase Anchor Proteins" by people in Profiles.
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Prikhodko O, Freund RK, Sullivan E, Kennedy MJ, Dell'Acqua ML. Amyloid-? Causes NMDA Receptor Dysfunction and Dendritic Spine Loss through mGluR1 and AKAP150-Anchored Calcineurin Signaling. J Neurosci. 2024 Sep 11; 44(37).
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Robinson EL, Tharp CA, Bagchi RA, McKinsey TA. Gravi-D peptide disrupts HDAC11 association with an AKAP to stimulate adipocyte thermogenic signaling. J Clin Invest. 2024 May 01; 134(9).
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Simmons SC, Flerlage WJ, Langlois LD, Shepard RD, Bouslog C, Thomas EH, Gouty KM, Sanderson JL, Gouty S, Cox BM, Dell'Acqua ML, Nugent FS. AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula. Commun Biol. 2024 03 20; 7(1):345.
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Sanderson JL, Freund RK, Gorski JA, Dell'Acqua ML. ?-Amyloid disruption of LTP/LTD balance is mediated by AKAP150-anchored PKA and Calcineurin regulation of Ca2+-permeable AMPA receptors. Cell Rep. 2021 10 05; 37(1):109786.
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Cochrane VA, Yang Z, Dell'Acqua ML, Shyng SL. AKAP79/150 coordinates leptin-induced PKA signaling to regulate KATP channel trafficking in pancreatic ?-cells. J Biol Chem. 2021 Jan-Jun; 296:100442.
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Murphy JG, Crosby KC, Dittmer PJ, Sather WA, Dell'Acqua ML. AKAP79/150 recruits the transcription factor NFAT to regulate signaling to the nucleus by neuronal L-type Ca2+ channels. Mol Biol Cell. 2019 07 01; 30(14):1743-1756.
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Purkey AM, Woolfrey KM, Crosby KC, Stich DG, Chick WS, Aoto J, Dell'Acqua ML. AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP. Cell Rep. 2018 10 23; 25(4):974-987.e4.
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Earp M, Tyrer JP, Winham SJ, Lin HY, Chornokur G, Dennis J, Aben KKH, Anton-Culver H, Antonenkova N, Bandera EV, Bean YT, Beckmann MW, Bjorge L, Bogdanova N, Brinton LA, Brooks-Wilson A, Bruinsma F, Bunker CH, Butzow R, Campbell IG, Carty K, Chang-Claude J, Cook LS, Cramer DW, Cunningham JM, Cybulski C, Dansonka-Mieszkowska A, Despierre E, Doherty JA, D?rk T, du Bois A, D?rst M, Easton DF, Eccles DM, Edwards RP, Ekici AB, Fasching PA, Fridley BL, Gentry-Maharaj A, Giles GG, Glasspool R, Goodman MT, Gronwald J, Harter P, Hein A, Heitz F, Hildebrandt MAT, Hillemanns P, Hogdall CK, H?gdall E, Hosono S, Iversen ES, Jakubowska A, Jensen A, Ji BT, Jung AY, Karlan BY, Kellar M, Kiemeney LA, Kiong Lim B, Kjaer SK, Krakstad C, Kupryjanczyk J, Lambrechts D, Lambrechts S, Le ND, Lele S, Lester J, Levine DA, Li Z, Liang D, Lissowska J, Lu K, Lubinski J, Lundvall L, Massuger LFAG, Matsuo K, McGuire V, McLaughlin JR, McNeish I, Menon U, Milne RL, Modugno F, Moysich KB, Ness RB, Nevanlinna H, Odunsi K, Olson SH, Orlow I, Orsulic S, Paul J, Pejovic T, Pelttari LM, Permuth JB, Pike MC, Poole EM, Rosen B, Rossing MA, Rothstein JH, Runnebaum IB, Rzepecka IK, Schernhammer E, Schwaab I, Shu XO, Shvetsov YB, Siddiqui N, Sieh W, Song H, Southey MC, Spiewankiewicz B, Sucheston-Campbell L, Tangen IL, Teo SH, Terry KL, Thompson PJ, Thomsen L, Tworoger SS, van Altena AM, Vergote I, Vestrheim Thomsen LC, Vierkant RA, Walsh CS, Wang-Gohrke S, Wentzensen N, Whittemore AS, Wicklund KG, Wilkens LR, Woo YL, Wu AH, Wu X, Xiang YB, Yang H, Zheng W, Ziogas A, Lee AW, Pearce CL, Berchuck A, Schildkraut JM, Ramus SJ, Monteiro ANA, Narod SA, Sellers TA, Gayther SA, Kelemen LE, Chenevix-Trench G, Risch HA, Pharoah PDP, Goode EL, Phelan CM. Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility. PLoS One. 2018; 13(7):e0197561.
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Jones DZ, Schmidt ML, Suman S, Hobbing KR, Barve SS, Gobejishvili L, Brock G, Klinge CM, Rai SN, Park J, Clark GJ, Agarwal R, Kidd LR. Micro-RNA-186-5p inhibition attenuates proliferation, anchorage independent growth and invasion in metastatic prostate cancer cells. BMC Cancer. 2018 04 13; 18(1):421.
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Sanderson JL, Scott JD, Dell'Acqua ML. Control of Homeostatic Synaptic Plasticity by AKAP-Anchored Kinase and Phosphatase Regulation of Ca2+-Permeable AMPA Receptors. J Neurosci. 2018 03 14; 38(11):2863-2876.
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