 Synapsins
"Synapsins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of synaptic vesicle-associated proteins involved in the short-term regulation of NEUROTRANSMITTER release. Synapsin I, the predominant member of this family, links SYNAPTIC VESICLES to ACTIN FILAMENTS in the presynaptic nerve terminal. These interactions are modulated by the reversible PHOSPHORYLATION of synapsin I through various signal transduction pathways. The protein is also a substrate for cAMP- and CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. It is believed that these functional properties are also shared by synapsin II.
| Descriptor ID |
D016704
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| MeSH Number(s) |
D12.776.631.750 D12.776.744.840
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Synapsins".
Below are MeSH descriptors whose meaning is more specific than "Synapsins".
This graph shows the total number of publications written about "Synapsins" by people in this website by year, and whether "Synapsins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Synapsins" by people in Profiles.
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Lovell MA, Lynn BC, Fister S, Bradley-Whitman M, Murphy MP, Beckett TL, Norris CM. A Novel Small Molecule Modulator of Amyloid Pathology. J Alzheimers Dis. 2016 05 04; 53(1):273-87.
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Edwards S, Graham DL, Bachtell RK, Self DW. Region-specific tolerance to cocaine-regulated cAMP-dependent protein phosphorylation following chronic self-administration. Eur J Neurosci. 2007 Apr; 25(7):2201-13.
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Wurtman RJ, Ulus IH, Cansev M, Watkins CJ, Wang L, Marzloff G. Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally. Brain Res. 2006 May 09; 1088(1):83-92.
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Coultrap SJ, Nixon KM, Alvestad RM, Valenzuela CF, Browning MD. Differential expression of NMDA receptor subunits and splice variants among the CA1, CA3 and dentate gyrus of the adult rat. Brain Res Mol Brain Res. 2005 Apr 27; 135(1-2):104-11.
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Marek L, Levresse V, Amura C, Zentrich E, Van Putten V, Nemenoff RA, Heasley LE. Multiple signaling conduits regulate global differentiation-specific gene expression in PC12 cells. J Cell Physiol. 2004 Dec; 201(3):459-69.
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Sze CI, Bi H, Kleinschmidt-DeMasters BK, Filley CM, Martin LJ. Selective regional loss of exocytotic presynaptic vesicle proteins in Alzheimer's disease brains. J Neurol Sci. 2000 Apr 15; 175(2):81-90.
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Stone LM, Browning MD, Finger TE. Differential distribution of the synapsins in the rat olfactory bulb. J Neurosci. 1994 Jan; 14(1):301-9.
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Browning MD, Dudek EM, Rapier JL, Leonard S, Freedman R. Significant reductions in synapsin but not synaptophysin specific activity in the brains of some schizophrenics. Biol Psychiatry. 1993 Oct 15; 34(8):529-35.
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Finger TE, Womble M, Kinnamon JC, Ueda T. Synapsin I-like immunoreactivity in nerve fibers associated with lingual taste buds of the rat. J Comp Neurol. 1990 Feb 08; 292(2):283-90.
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Goldenring JR, Lasher RS, Vallano ML, Ueda T, Naito S, Sternberger NH, Sternberger LA, DeLorenzo RJ. Association of synapsin I with neuronal cytoskeleton. Identification in cytoskeletal preparations in vitro and immunocytochemical localization in brain of synapsin I. J Biol Chem. 1986 Jun 25; 261(18):8495-504.
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