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Sabrina Leigh Spencer

TitleAssociate Professor
InstitutionUniversity of Colorado Boulder
DepartmentBiochemistry

    Collapse Research 
    Collapse research activities and funding
    R01GM152642     (SPENCER, SABRINA LEIGH)Sep 1, 2024 - Aug 31, 2028
    NIH
    Molecular basis of cell-cycle plasticity and robustness
    Role: Principal Investigator
    R01AG082942     (SPENCER, SABRINA LEIGH)Sep 30, 2023 - May 31, 2028
    NIH
    Progressive states of cell-cycle withdrawal
    Role: Principal Investigator
    DP2CA238330     (SPENCER, SABRINA LEIGH)Sep 30, 2018 - May 31, 2023
    NIH
    PROLIFERATION-QUIESCENCE CONTROL IN SINGLE CELLS: INTEGRATION OF MITOGEN, NUTRIENT, AND STRESS SIGNALING
    Role: Principal Investigator
    K22CA188144     (SPENCER, SABRINA LEIGH)Sep 15, 2014 - Aug 31, 2017
    NIH
    Proliferation-quiescence control by integration of stress and mitogen signaling
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. McNally DL, Macdougall LJ, Kirkpatrick BE, Maduka CV, Hoffman TE, Fairbanks BD, Bowman CN, Spencer SL, Anseth KS. Reversible Intracellular Gelation of MCF10A Cells Enables Programmable Control Over 3D Spheroid Growth. Adv Healthc Mater. 2024 03; 13(7):e2302528. PMID: 38142299.
      View in: PubMed
    2. Rong Y, Darnell AM, Sapp KM, Vander Heiden MG, Spencer SL. Cells use multiple mechanisms for cell-cycle arrest upon withdrawal of individual amino acids. Cell Rep. 2023 12 26; 42(12):113539. PMID: 38070134.
      View in: PubMed
    3. Hoffman TE, Nangia V, Ill CR, Passanisi VJ, Armstrong C, Yang C, Spencer SL. Multiple cancers escape from multiple MAPK pathway inhibitors and use DNA replication stress signaling to tolerate aberrant cell cycles. Sci Signal. 2023 08; 16(796):eade8744. PMID: 37527351.
      View in: PubMed
    4. Ashraf HM, Fernandez B, Spencer SL. The intensities of canonical senescence biomarkers integrate the duration of cell-cycle withdrawal. Nat Commun. 2023 07 27; 14(1):4527. PMID: 37500655.
      View in: PubMed
    5. Armstrong C, Passanisi VJ, Ashraf HM, Spencer SL. Cyclin E/CDK2 and feedback from soluble histone protein regulate the S phase burst of histone biosynthesis. Cell Rep. 2023 07 25; 42(7):112768. PMID: 37428633.
      View in: PubMed
    6. Lammer NC, Ashraf HM, Ugay DA, Spencer SL, Allen MA, Batey RT, Wuttke DS. RNA binding by the glucocorticoid receptor attenuates dexamethasone-induced gene activation. Sci Rep. 2023 06 09; 13(1):9385. PMID: 37296231.
      View in: PubMed
    7. Arora M, Moser J, Hoffman TE, Watts LP, Min M, Musteanu M, Rong Y, Ill CR, Nangia V, Schneider J, Sanclemente M, Lapek J, Nguyen L, Niessen S, Dann S, VanArsdale T, Barbacid M, Miller N, Spencer SL. Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity. Cell. 2023 06 08; 186(12):2628-2643.e21. PMID: 37267950.
      View in: PubMed
    8. Hoffman TE, Yang C, Nangia V, Ill CR, Spencer SL. Multiple cancer types rapidly escape from multiple MAPK inhibitors to generate mutagenesis-prone subpopulations. bioRxiv. 2023 Mar 21. PMID: 36993538.
      View in: PubMed
    9. Ashraf HM, Fernandez B, Spencer SL. The intensities of canonical senescence biomarkers integrate the duration of cell-cycle withdrawal. bioRxiv. 2023 Mar 21. PMID: 36993379.
      View in: PubMed
    10. Armstrong C, Passanisi VJ, Ashraf HM, Spencer SL. Cyclin E/CDK2 and feedback from soluble histone protein regulate the S phase burst of histone biosynthesis. bioRxiv. 2023 Mar 18. PMID: 36993620.
      View in: PubMed
    11. Chen JY, Hug C, Reyes J, Tian C, Gerosa L, Fr?hlich F, Ponsioen B, Snippert HJG, Spencer SL, Jambhekar A, Sorger PK, Lahav G. Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction. Cell Rep. 2023 03 28; 42(3):112252. PMID: 36920903.
      View in: PubMed
    12. Macdougall LJ, Hoffman TE, Kirkpatrick BE, Fairbanks BD, Bowman CN, Spencer SL, Anseth KS. Intracellular Crowding by Bio-Orthogonal Hydrogel Formation Induces Reversible Molecular Stasis. Adv Mater. 2022 Aug; 34(31):e2202882. PMID: 35671709.
      View in: PubMed
    13. Promislow D, Anderson RM, Scheffer M, Crespi B, DeGregori J, Harris K, Horowitz BN, Levine ME, Riolo MA, Schneider DS, Spencer SL, Valenzano DR, Hochberg ME. Resilience integrates concepts in aging research. iScience. 2022 May 20; 25(5):104199. PMID: 35494229.
      View in: PubMed
    14. Cable J, Elowitz MB, Domingos AI, Habib N, Itzkovitz S, Hamidzada H, Balzer MS, Yanai I, Liberali P, Whited J, Streets A, Cai L, Stergachis AB, Hong CKY, Keren L, Guilliams M, Alon U, Shalek AK, Hamel R, Pfau SJ, Raj A, Quake SR, Zhang NR, Fan J, Trapnell C, Wang B, Greenwald NF, Vento-Tormo R, Santos SDM, Spencer SL, Garcia HG, Arekatla G, Gaiti F, Arbel-Goren R, Rulands S, Junker JP, Klein AM, Morris SA, Murray JI, Galloway KE, Ratz M, Romeike M. Single cell biology-a Keystone Symposia report. Ann N Y Acad Sci. 2021 12; 1506(1):74-97. PMID: 34605044.
      View in: PubMed
    15. Armstrong C, Spencer SL. Replication-dependent histone biosynthesis is coupled to cell-cycle commitment. Proc Natl Acad Sci U S A. 2021 08 03; 118(31). PMID: 34326254.
      View in: PubMed
    16. Yang C, Tian C, Hoffman TE, Jacobsen NK, Spencer SL. Melanoma subpopulations that rapidly escape MAPK pathway inhibition incur DNA damage and rely on stress signalling. Nat Commun. 2021 03 19; 12(1):1747. PMID: 33741929.
      View in: PubMed
    17. Adikes RC, Kohrman AQ, Martinez MAQ, Palmisano NJ, Smith JJ, Medwig-Kinney TN, Min M, Sallee MD, Ahmed OB, Kim N, Liu S, Morabito RD, Weeks N, Zhao Q, Zhang W, Feldman JL, Barkoulas M, Pani AM, Spencer SL, Martin BL, Matus DQ. Visualizing the metazoan proliferation-quiescence decision in vivo. Elife. 2020 12 22; 9. PMID: 33350383.
      View in: PubMed
    18. Tian C, Yang C, Spencer SL. EllipTrack: A Global-Local Cell-Tracking Pipeline for 2D Fluorescence Time-Lapse Microscopy. Cell Rep. 2020 08 04; 32(5):107984. PMID: 32755578.
      View in: PubMed
    19. Min M, Rong Y, Tian C, Spencer SL. Temporal integration of mitogen history in mother cells controls proliferation of daughter cells. Science. 2020 06 12; 368(6496):1261-1265. PMID: 32241885.
      View in: PubMed
    20. Ashraf HM, Moser J, Spencer SL. Senescence Evasion in Chemotherapy: A Sweet Spot for p21. Cell. 2019 07 11; 178(2):267-269. PMID: 31299197.
      View in: PubMed
    21. Min M, Spencer SL. Spontaneously slow-cycling subpopulations of human cells originate from activation of stress-response pathways. PLoS Biol. 2019 03; 17(3):e3000178. PMID: 30865623.
      View in: PubMed
    22. Moser J, Miller I, Carter D, Spencer SL. Control of the Restriction Point by Rb and p21. Proc Natl Acad Sci U S A. 2018 08 28; 115(35):E8219-E8227. PMID: 30111539.
      View in: PubMed
    23. Miller I, Min M, Yang C, Tian C, Gookin S, Carter D, Spencer SL. Ki67 is a Graded Rather than a Binary Marker of Proliferation versus Quiescence. Cell Rep. 2018 07 31; 24(5):1105-1112.e5. PMID: 30067968.
      View in: PubMed
    24. Arora M, Spencer SL. A Cell-Cycle "Safe Space" for Surviving Chemotherapy. Cell Syst. 2017 09 27; 5(3):161-162. PMID: 28957649.
      View in: PubMed
    25. Gookin S, Min M, Phadke H, Chung M, Moser J, Miller I, Carter D, Spencer SL. A map of protein dynamics during cell-cycle progression and cell-cycle exit. PLoS Biol. 2017 Sep; 15(9):e2003268. PMID: 28892491.
      View in: PubMed
    26. Arora M, Moser J, Phadke H, Basha AA, Spencer SL. Endogenous Replication Stress in Mother Cells Leads to Quiescence of Daughter Cells. Cell Rep. 2017 05 16; 19(7):1351-1364. PMID: 28514656.
      View in: PubMed
    27. Cappell SD, Chung M, Jaimovich A, Spencer SL, Meyer T. Irreversible APC(Cdh1) Inactivation Underlies the Point of No Return for Cell-Cycle Entry. Cell. 2016 Jun 30; 166(1):167-80. PMID: 27368103.
      View in: PubMed
    28. Overton KW, Spencer SL, Noderer WL, Meyer T, Wang CL. Basal p21 controls population heterogeneity in cycling and quiescent cell cycle states. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):E4386-93. PMID: 25267623.
      View in: PubMed
    29. Spencer SL, Cappell SD, Tsai FC, Overton KW, Wang CL, Meyer T. The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit. Cell. 2013 Oct 10; 155(2):369-83. PMID: 24075009.
      View in: PubMed
    30. Flusberg DA, Roux J, Spencer SL, Sorger PK. Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes. Mol Biol Cell. 2013 Jul; 24(14):2186-200. PMID: 23699397.
      View in: PubMed
    31. Gaudet S, Spencer SL, Chen WW, Sorger PK. Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis. PLoS Comput Biol. 2012; 8(4):e1002482. PMID: 22570596.
      View in: PubMed
    32. Spencer SL, Sorger PK. Measuring and modeling apoptosis in single cells. Cell. 2011 Mar 18; 144(6):926-39. PMID: 21414484.
      View in: PubMed
    33. Kim KA, Spencer SL, Albeck JG, Burke JM, Sorger PK, Gaudet S, Kim DH. Systematic calibration of a cell signaling network model. BMC Bioinformatics. 2010 Apr 23; 11:202. PMID: 20416044.
      View in: PubMed
    34. Niepel M, Spencer SL, Sorger PK. Non-genetic cell-to-cell variability and the consequences for pharmacology. Curr Opin Chem Biol. 2009 Dec; 13(5-6):556-61. PMID: 19833543.
      View in: PubMed
    35. Spencer SL, Gaudet S, Albeck JG, Burke JM, Sorger PK. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature. 2009 May 21; 459(7245):428-32. PMID: 19363473.
      View in: PubMed
    36. Pepper JW, Scott Findlay C, Kassen R, Spencer SL, Maley CC. Cancer research meets evolutionary biology. Evol Appl. 2009 Feb; 2(1):62-70. PMID: 25567847.
      View in: PubMed
    37. Albeck JG, Burke JM, Spencer SL, Lauffenburger DA, Sorger PK. Modeling a snap-action, variable-delay switch controlling extrinsic cell death. PLoS Biol. 2008 Dec 02; 6(12):2831-52. PMID: 19053173.
      View in: PubMed
    38. Spencer SL, Gerety RA, Pienta KJ, Forrest S. Modeling somatic evolution in tumorigenesis. PLoS Comput Biol. 2006 Aug 18; 2(8):e108. PMID: 16933983.
      View in: PubMed
    39. Spencer SL, Berryman MJ, Garc?a JA, Abbott D. An ordinary differential equation model for the multistep transformation to cancer. J Theor Biol. 2004 Dec 21; 231(4):515-24. PMID: 15488528.
      View in: PubMed
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