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Anthony N. Gerber

TitleAffiliate - NJH
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Research 
    Collapse research activities and funding
    R13HL168870     (GERBER, ANTHONY N)May 1, 2023 - Apr 30, 2024
    NIH
    Aspen Lung Conference: Asthma: Pathogenesis, Phenotypes, Therapies and Gaps
    Role: Principal Investigator
    R01HL109557     (GERBER, ANTHONY N)Apr 15, 2012 - Feb 28, 2026
    NIH
    Mechanisms and Consequences of Gene Induction by Glucocorticoids in Airway Smooth Muscle
    Role: Principal Investigator
    K08HL077159     (GERBER, ANTHONY N)Sep 29, 2005 - Jun 30, 2010
    NIH
    Gli1 in murine lung development and differentiation
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sasse SK, Gruca M, Allen MA, Kadiyala V, Song T, Gally F, Gupta A, Pufall MA, Dowell RD, Gerber AN. Nascent transcript analysis of glucocorticoid crosstalk with TNF defines primary and cooperative inflammatory repression. Genome Res. 2019 11; 29(11):1753-1765. PMID: 31519741.
      View in: PubMed
    2. Sasse SK, Gerber AN. Old Cells in Young Airway Smooth Muscle: Does Neonatal Senescence Cause Lifelong Airway Obstruction? Am J Respir Cell Mol Biol. 2019 Jul; 61(1):3-4. PMID: 30576224.
      View in: PubMed
    3. Riemondy KA, Jansing NL, Jiang P, Redente EF, Gillen AE, Fu R, Miller AJ, Spence JR, Gerber AN, Hesselberth JR, Zemans RL. Single cell RNA sequencing identifies TGF? as a key regenerative cue following LPS-induced lung injury. JCI Insight. 2019 03 26; 5. PMID: 30913038.
      View in: PubMed
    4. Britt RD, Thompson MA, Sasse S, Pabelick CM, Gerber AN, Prakash YS. Th1 cytokines TNF-a and IFN-? promote corticosteroid resistance in developing human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2019 01 01; 316(1):L71-L81. PMID: 30335498.
      View in: PubMed
    5. Evans CM, Seibold MA, Gerber AN. SPDEFending the Lung through Mucin Expression. Am J Respir Cell Mol Biol. 2018 09; 59(3):287-288. PMID: 29723043.
      View in: PubMed
    6. Rider CF, Altonsy MO, Mostafa MM, Shah SV, Sasse S, Manson ML, Yan D, K?rrman-M?rdh C, Miller-Larsson A, Gerber AN, Giembycz MA, Newton R. Long-Acting ?2-Adrenoceptor Agonists Enhance Glucocorticoid Receptor (GR)-Mediated Transcription by Gene-Specific Mechanisms Rather Than Generic Effects via GR. Mol Pharmacol. 2018 09; 94(3):1031-1046. PMID: 29959223.
      View in: PubMed
    7. Li Y, Liu B, Harmacek L, Long Z, Liang J, Lukin K, Leach SM, O'Connor B, Gerber AN, Hagman J, Roers A, Finkelman FD, Huang H. The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis. J Allergy Clin Immunol. 2018 10; 142(4):1173-1184. PMID: 29277702.
      View in: PubMed
    8. Swaminathan S, Qirko K, Smith T, Corcoran E, Wysham NG, Bazaz G, Kappel G, Gerber AN. A machine learning approach to triaging patients with chronic obstructive pulmonary disease. PLoS One. 2017; 12(11):e0188532. PMID: 29166411.
      View in: PubMed
    9. Sasse SK, Kadiyala V, Danhorn T, Panettieri RA, Phang TL, Gerber AN. Glucocorticoid Receptor ChIP-Seq Identifies PLCD1 as a KLF15 Target that Represses Airway Smooth Muscle Hypertrophy. Am J Respir Cell Mol Biol. 2017 08; 57(2):226-237. PMID: 28375666.
      View in: PubMed
    10. Helling BA, Gerber AN, Kadiyala V, Sasse SK, Pedersen BS, Sparks L, Nakano Y, Okamoto T, Evans CM, Yang IV, Schwartz DA. Regulation of MUC5B Expression in Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2017 07; 57(1):91-99. PMID: 28272906.
      View in: PubMed
    11. Katial RK, Bensch GW, Busse WW, Chipps BE, Denson JL, Gerber AN, Jacobs JS, Kraft M, Martin RJ, Nair P, Wechsler ME. Changing Paradigms in the Treatment of Severe Asthma: The Role of Biologic Therapies. J Allergy Clin Immunol Pract. 2017 Mar - Apr; 5(2S):S1-S14. PMID: 28143691.
      View in: PubMed
    12. Altonsy MO, Mostafa MM, Gerber AN, Newton R. Long-acting ?2-agonists promote glucocorticoid-mediated repression of NF-?B by enhancing expression of the feedback regulator TNFAIP3. Am J Physiol Lung Cell Mol Physiol. 2017 Mar 01; 312(3):L358-L370. PMID: 28039105.
      View in: PubMed
    13. Gerber AN. Measuring safety of inhaled corticosteroids in asthma. Ann Allergy Asthma Immunol. 2016 12; 117(6):577-581. PMID: 27979012.
      View in: PubMed
    14. Sasse SK, Altonsy MO, Kadiyala V, Cao G, Panettieri RA, Gerber AN. Glucocorticoid and TNF signaling converge at A20 (TNFAIP3) to repress airway smooth muscle cytokine expression. Am J Physiol Lung Cell Mol Physiol. 2016 08 01; 311(2):L421-32. PMID: 27371733.
      View in: PubMed
    15. Kadiyala V, Sasse SK, Altonsy MO, Berman R, Chu HW, Phang TL, Gerber AN. Cistrome-based Cooperation between Airway Epithelial Glucocorticoid Receptor and NF-?B Orchestrates Anti-inflammatory Effects. J Biol Chem. 2016 Jun 10; 291(24):12673-12687. PMID: 27076634.
      View in: PubMed
    16. Kadiyala V, Sasse SK, Altonsy MO, Phang TL, Gerber AN. Cistrome Analysis of Glucocorticoid Receptor Activity in Bronchial Epithelial Cells Defines Novel Mechanisms of Steroid Efficacy. Ann Am Thorac Soc. 2016 Mar; 13 Suppl 1:S103. PMID: 27027943.
      View in: PubMed
    17. Kraft M, Gerber AN, Szefler SJ, Wechsler ME. Introduction to the 58th Annual Thomas L. Petty Aspen Lung Conference: Asthma 2015: Mechanisms to Personalized Medicine. Ann Am Thorac Soc. 2016 Mar; 13 Suppl 1:S23-4. PMID: 27027947.
      View in: PubMed
    18. Morrison-Nozik A, Anand P, Zhu H, Duan Q, Sabeh M, Prosdocimo DA, Lemieux ME, Nordsborg N, Russell AP, MacRae CA, Gerber AN, Jain MK, Haldar SM. Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program. Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):E6780-9. PMID: 26598680.
      View in: PubMed
    19. Sasse SK, Zuo Z, Kadiyala V, Zhang L, Pufall MA, Jain MK, Phang TL, Stormo GD, Gerber AN. Response Element Composition Governs Correlations between Binding Site Affinity and Transcription in Glucocorticoid Receptor Feed-forward Loops. J Biol Chem. 2015 Aug 07; 290(32):19756-69. PMID: 26088140.
      View in: PubMed
    20. Gerber AN. Glucocorticoids and the Lung. Adv Exp Med Biol. 2015; 872:279-98. PMID: 26215999.
      View in: PubMed
    21. Sasse SK, Gerber AN. Feed-forward transcriptional programming by nuclear receptors: regulatory principles and therapeutic implications. Pharmacol Ther. 2015 Jan; 145:85-91. PMID: 25168919.
      View in: PubMed
    22. Altonsy MO, Sasse SK, Phang TL, Gerber AN. Context-dependent cooperation between nuclear factor ?B (NF-?B) and the glucocorticoid receptor at a TNFAIP3 intronic enhancer: a mechanism to maintain negative feedback control of inflammation. J Biol Chem. 2014 Mar 21; 289(12):8231-9. PMID: 24500711.
      View in: PubMed
    23. Gerber AN. Glucocorticoids and airway smooth muscle: some answers, more questions. Am J Respir Crit Care Med. 2013 May 15; 187(10):1040-1. PMID: 23675710.
      View in: PubMed
    24. Sasse SK, Mailloux CM, Barczak AJ, Wang Q, Altonsy MO, Jain MK, Haldar SM, Gerber AN. The glucocorticoid receptor and KLF15 regulate gene expression dynamics and integrate signals through feed-forward circuitry. Mol Cell Biol. 2013 Jun; 33(11):2104-15. PMID: 23508109.
      View in: PubMed
    25. Haldar SM, Jeyaraj D, Anand P, Zhu H, Lu Y, Prosdocimo DA, Eapen B, Kawanami D, Okutsu M, Brotto L, Fujioka H, Kerner J, Rosca MG, McGuinness OP, Snow RJ, Russell AP, Gerber AN, Bai X, Yan Z, Nosek TM, Brotto M, Hoppel CL, Jain MK. Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6739-44. PMID: 22493257.
      View in: PubMed
    26. Gerber AN. Genetics of glucocorticoids in asthma. N Engl J Med. 2011 12 22; 365(25):2435; author reply 2435-6. PMID: 22187997.
      View in: PubMed
    27. Gerber AN, Sutherland ER. Vitamin D and asthma: another dimension. Am J Respir Crit Care Med. 2011 Dec 15; 184(12):1324-5. PMID: 22174108.
      View in: PubMed
    28. Masuno K, Haldar SM, Jeyaraj D, Mailloux CM, Huang X, Panettieri RA, Jain MK, Gerber AN. Expression profiling identifies Klf15 as a glucocorticoid target that regulates airway hyperresponsiveness. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):642-9. PMID: 21257922.
      View in: PubMed
    29. Gerber AN, Masuno K, Diamond MI. Discovery of selective glucocorticoid receptor modulators by multiplexed reporter screening. Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4929-34. PMID: 19255438.
      View in: PubMed
    30. Yun AJ, Lee PY, Gerber AN. Integrating systems biology and medical imaging: understanding disease distribution in the lung model. AJR Am J Roentgenol. 2006 Apr; 186(4):925-30. PMID: 16554557.
      View in: PubMed
    31. Yun AJ, Bazar KA, Gerber A, Lee PY, Daniel SM. The dynamic range of biologic functions and variation of many environmental cues may be declining in the modern age: implications for diseases and therapeutics. Med Hypotheses. 2005; 65(1):173-8. PMID: 15893136.
      View in: PubMed
    32. Yun AJ, Bazar KA, Lee PY, Gerber A, Daniel SM. The smoking gun: many conditions associated with tobacco exposure may be attributable to paradoxical compensatory autonomic responses to nicotine. Med Hypotheses. 2005; 64(6):1073-9. PMID: 15823687.
      View in: PubMed
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