 DNA Helicases
"DNA Helicases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Proteins that catalyze the unwinding of duplex DNA during replication by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. In addition DNA helicases are DNA-dependent ATPases that harness the free energy of ATP hydrolysis to translocate DNA strands.
| Descriptor ID |
D004265
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| MeSH Number(s) |
D08.811.277.040.025.159 D08.811.399.340
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| Concept/Terms |
DNA Helicases- DNA Helicases
- Helicases, DNA
- DNA Unwinding Proteins
- Unwinding Proteins, DNA
ATP-Dependent DNA Helicases- ATP-Dependent DNA Helicases
- ATP Dependent DNA Helicases
- DNA Helicases, ATP-Dependent
- Helicases, ATP-Dependent DNA
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Below are MeSH descriptors whose meaning is more general than "DNA Helicases".
Below are MeSH descriptors whose meaning is more specific than "DNA Helicases".
This graph shows the total number of publications written about "DNA Helicases" by people in this website by year, and whether "DNA Helicases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 1997 | 1 | 1 | 2 | | 1998 | 1 | 0 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 4 | 0 | 4 | | 2002 | 1 | 1 | 2 | | 2003 | 2 | 0 | 2 | | 2004 | 4 | 1 | 5 | | 2005 | 3 | 1 | 4 | | 2007 | 1 | 0 | 1 | | 2008 | 2 | 1 | 3 | | 2009 | 6 | 1 | 7 | | 2010 | 2 | 1 | 3 | | 2011 | 3 | 0 | 3 | | 2012 | 4 | 1 | 5 | | 2013 | 3 | 1 | 4 | | 2014 | 0 | 1 | 1 | | 2015 | 4 | 2 | 6 | | 2016 | 1 | 2 | 3 | | 2017 | 3 | 0 | 3 | | 2018 | 2 | 2 | 4 | | 2019 | 0 | 4 | 4 | | 2020 | 3 | 0 | 3 | | 2021 | 3 | 1 | 4 | | 2022 | 2 | 3 | 5 | | 2023 | 1 | 4 | 5 | | 2024 | 3 | 2 | 5 | | 2025 | 5 | 0 | 5 | | 2026 | 1 | 1 | 2 |
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Below are the most recent publications written about "DNA Helicases" by people in Profiles.
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Abaev-Schneiderman E, Nguyen L, Shalev R, Biton TE, Chopra A, Jagadeesan G, Sevilla-Sanchez D, Tickotsky Moskovitz N, Levin L, Feldman M, Van Rechem C, Levy D. ACTB methylation regulates SMARCA4 genomic occupancy to promote translation and reduce adhesion in colorectal cancer cells. Genome Res. 2026 04 07; 36(4):684-694.
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Lopriore P, Ünlütürk Z, Klopstock T, Karaa A, Rouzier C, Domínguez-González C, Lamperti C, Mancuso M, Cecchi G, Montano V, Siciliano G, Nicoletta V, Maioli M, Primiano G, Servidei S, La Morgia C, Carelli V, Valentino ML, Caporali L, Arena IG, Musumeci O, Lopergolo D, Malandrini A, Gallus GN, Filosto M, Bello L, Pegoraro E, Comi GP, Magri F, Ronchi D, Di Fonzo A, Percetti M, Azzimonti M, Büchner B, Prokisch H, Bermejo-Guerrero L, Procaccio V, Gaignard P, Echaniz-Laguna A, Schiff M, Rötig A, Toutain A, Paquis-Flucklinger V, Morel G, Robin S, Nadaj-Pakleza A, Chanson JB, Chaussenot A, Ait-El-Mkadem Saadi S, Trimouille A, Tranchant C, Salort-Campana E, Bieth E, Sacconi S, Duval F, Restrepo Vera JL, Molnar MJ, Vissing J, Haas R, Larson A, Enns GM, Parikh S, Goldstein A, Hirano M. Clinical and Genotypic Spectrum of Twinkle-Related Disorders: Insights From a Multinational Cohort Study. Neurology. 2026 Feb 10; 106(3):e214401.
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Dam M, Moreno DF, Brownlow N, Furst A, Spiegelhalter C, Mendoza M. Roles of Srs2/PARI-family DNA helicases in NoCut checkpoint signaling and abscission regulation. J Cell Biol. 2025 Dec 01; 224(12).
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Clune S, Awolade P, Esquer H, Zhou Q, LaBarbera DV. CHD1L in cancer and beyond: structure, oncogenic functions, and therapeutic potential. J Exp Clin Cancer Res. 2025 May 30; 44(1):167.
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Mahajan S, Kumar R, Singh A, Dhaka P, Pareek A, Kumar P, Tomar S. Targeting the host protein G3BP1 for the discovery of novel antiviral inhibitors against Chikungunya virus. Virology. 2025 07; 608:110551.
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Wu G, Taylor E, Youmans DT, Arnoult N, Cech TR. Rapid dynamics allow the low-abundance RTEL1 helicase to promote telomere replication. Nucleic Acids Res. 2025 Feb 27; 53(5).
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Esquer H, Zhou Q, LaBarbera DV. Targeted Inhibition of CHD1L by OTI-611 Reprograms Chemotherapy and Targeted Therapy-Induced Cell Cycle Arrest and Suppresses Proliferation to Produce Synergistic Antitumor Effects in Breast and Colorectal Cancer. Cells. 2025 02 20; 14(5).
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Sala R, Esquer H, Kellett T, Clune S, Awolade P, Pike LA, Zhou Q, Messersmith WA, LaBarbera DV. CHD1L Inhibitor OTI-611 Synergizes with Chemotherapy to Enhance Antitumor Efficacy and Prolong Survival in Colorectal Cancer Mouse Models. Int J Mol Sci. 2024 Dec 07; 25(23).
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Parker DM, Tauber D, Parker R. G3BP1 promotes intermolecular RNA-RNA interactions during RNA condensation. Mol Cell. 2025 Feb 06; 85(3):571-584.e7.
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Aboulache BL, Hoitsma NM, Luger K. Phosphorylation regulates the chromatin remodeler SMARCAD1 in nucleosome binding, ATP hydrolysis, and histone exchange. J Biol Chem. 2024 12; 300(12):107893.
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