 Myosin Heavy Chains
"Myosin Heavy Chains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The larger subunits of MYOSINS. The heavy chains have a molecular weight of about 230 kDa and each heavy chain is usually associated with a dissimilar pair of MYOSIN LIGHT CHAINS. The heavy chains possess actin-binding and ATPase activity.
| Descriptor ID |
D018995
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| MeSH Number(s) |
D05.750.078.730.475.100 D08.811.277.040.025.193.750.249 D12.776.210.500.600.100 D12.776.220.525.475.100
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| Concept/Terms |
Myosin Heavy Chains- Myosin Heavy Chains
- Heavy Chains, Myosin
- Myosin Heavy Chain
- Heavy Chain, Myosin
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Below are MeSH descriptors whose meaning is more general than "Myosin Heavy Chains".
Below are MeSH descriptors whose meaning is more specific than "Myosin Heavy Chains".
This graph shows the total number of publications written about "Myosin Heavy Chains" by people in this website by year, and whether "Myosin Heavy Chains" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 3 | 3 | | 1996 | 3 | 0 | 3 | | 1997 | 5 | 2 | 7 | | 1998 | 1 | 1 | 2 | | 1999 | 4 | 1 | 5 | | 2000 | 3 | 3 | 6 | | 2001 | 4 | 4 | 8 | | 2002 | 3 | 3 | 6 | | 2003 | 2 | 2 | 4 | | 2004 | 4 | 1 | 5 | | 2005 | 3 | 5 | 8 | | 2006 | 3 | 3 | 6 | | 2007 | 0 | 2 | 2 | | 2008 | 3 | 0 | 3 | | 2009 | 1 | 4 | 5 | | 2010 | 2 | 3 | 5 | | 2011 | 2 | 2 | 4 | | 2012 | 2 | 1 | 3 | | 2013 | 4 | 2 | 6 | | 2014 | 0 | 1 | 1 | | 2015 | 3 | 3 | 6 | | 2016 | 2 | 0 | 2 | | 2018 | 1 | 0 | 1 | | 2019 | 2 | 2 | 4 | | 2020 | 1 | 1 | 2 | | 2021 | 2 | 2 | 4 | | 2022 | 1 | 0 | 1 | | 2023 | 2 | 0 | 2 |
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Below are the most recent publications written about "Myosin Heavy Chains" by people in Profiles.
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Lee LA, Barrick SK, Buvoli AE, Walklate J, Stump WT, Geeves M, Greenberg MJ, Leinwand LA. Distinct effects of two hearing loss-associated mutations in?the sarcomeric myosin MYH7b. J Biol Chem. 2023 05; 299(5):104631.
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Queeno SR, Reiser PJ, Orr CM, Capellini TD, Sterner KN, O'Neill MC. Human and African ape myosin heavy chain content and the evolution of hominin skeletal muscle. Comp Biochem Physiol A Mol Integr Physiol. 2023 07; 281:111415.
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Lee LA, Barrick SK, Meller A, Walklate J, Lotthammer JM, Tay JW, Stump WT, Bowman G, Geeves MA, Greenberg MJ, Leinwand LA. Functional divergence of the sarcomeric myosin, MYH7b, supports species-specific biological roles. J Biol Chem. 2023 01; 299(1):102657.
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Lee LA, Broadwell LJ, Buvoli M, Leinwand LA. Nonproductive Splicing Prevents Expression of MYH7b Protein in the Mammalian Heart. J Am Heart Assoc. 2021 07 20; 10(14):e020965.
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Reynolds ND, Aceves NM, Liu JL, Compton JR, Leary DH, Freitas BT, Pegan SD, Doctor KZ, Wu FY, Hu X, Legler PM. The SARS-CoV-2 SSHHPS Recognized by the Papain-like Protease. ACS Infect Dis. 2021 06 11; 7(6):1483-1502.
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Broadwell LJ, Smallegan MJ, Rigby KM, Navarro-Arriola JS, Montgomery RL, Rinn JL, Leinwand LA. Myosin 7b is a regulatory long noncoding RNA (lncMYH7b) in the human heart. J Biol Chem. 2021 Jan-Jun; 296:100694.
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Dhagia V, Kitagawa A, Jacob C, Zheng C, D'Alessandro A, Edwards JG, Rocic P, Gupte R, Gupte SA. G6PD activity contributes to the regulation of histone acetylation and gene expression in smooth muscle cells and to the pathogenesis of vascular diseases. Am J Physiol Heart Circ Physiol. 2021 03 01; 320(3):H999-H1016.
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Lakdawala NK, Olivotto I, Day SM, Han L, Ashley EA, Michels M, Ingles J, Semsarian C, Jacoby D, Jefferies JL, Colan SD, Pereira AC, Rossano JW, Wittekind S, Ware JS, Saberi S, Helms AS, Cirino AL, Leinwand LA, Seidman CE, Ho CY. Associations Between Female Sex, Sarcomere Variants, and Clinical Outcomes in Hypertrophic Cardiomyopathy. Circ Genom Precis Med. 2021 02; 14(1):e003062.
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Otterpohl KL, Busselman BW, Ratnayake I, Hart RG, Hart KR, Evans CM, Phillips CL, Beach JR, Ahrenkiel P, Molitoris BA, Surendran K, Chandrasekar I. Conditional Myh9 and Myh10 inactivation in adult mouse renal epithelium results in progressive kidney disease. JCI Insight. 2020 11 05; 5(21).
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Gilbert MA, Schultz-Rogers L, Rajagopalan R, Grochowski CM, Wilkins BJ, Biswas S, Conlin LK, Fiorino KN, Dhamija R, Pack MA, Klee EW, Piccoli DA, Spinner NB. Protein-elongating mutations in MYH11 are implicated in a dominantly inherited smooth muscle dysmotility syndrome with severe esophageal, gastric, and intestinal disease. Hum Mutat. 2020 05; 41(5):973-982.
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