 RecQ Helicases
"RecQ Helicases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of structurally-related DNA helicases that play an essential role in the maintenance of genome integrity. RecQ helicases were originally discovered in E COLI and are highly conserved across both prokaryotic and eukaryotic organisms. Genetic mutations that result in loss of RecQ helicase activity gives rise to disorders that are associated with CANCER predisposition and premature aging.
| Descriptor ID |
D053484
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| MeSH Number(s) |
D08.811.277.040.025.159.249 D08.811.399.340.249
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| Concept/Terms |
RecQ Helicases- RecQ Helicases
- Helicases, RecQ
- RecQ Protein
- RecQ Family of DNA Helicases
RecQL Helicase- RecQL Helicase
- Helicase, RecQL
- RECQL1 Helicase
- Helicase, RECQL1
- DNA Helicase RecQL
- DNA-Dependent ATPase Q1
- DNA Dependent ATPase Q1
- ATP-Dependent DNA Helicase Q1
- ATP Dependent DNA Helicase Q1
- DNA Helicase Q1
RecQ4 Helicase- RecQ4 Helicase
- RTS Helicase
- Helicase, RTS
- RecQL4 Helicase
- Helicase, RecQL4
- ATP-Dependent DNA Helicase Q4
- ATP Dependent DNA Helicase Q4
- DNA Helicase RecQL4
RecQ5 Helicase- RecQ5 Helicase
- Helicase, RecQ5
- RecQ5L Helicase
- Helicase, RecQ5L
- ATP-Dependent DNA Helicase Q5
- ATP Dependent DNA Helicase Q5
RecQ2 Helicase- RecQ2 Helicase
- Helicase, RecQ2
- RecQL3 Helicase
- Helicase, RecQL3
- DNA Helicase, RecQ-like type 2
- DNA Helicase, RecQ like type 2
RecQ3 Helicase- RecQ3 Helicase
- Helicase, RecQ3
- RecQL2 Helicase
- Helicase, RecQL2
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Below are MeSH descriptors whose meaning is more general than "RecQ Helicases".
Below are MeSH descriptors whose meaning is more specific than "RecQ Helicases".
This graph shows the total number of publications written about "RecQ Helicases" by people in this website by year, and whether "RecQ Helicases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 | | 2004 | 0 | 3 | 3 | | 2005 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2009 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2017 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "RecQ Helicases" by people in Profiles.
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Viceconte N, Loriot A, Lona Abreu P, Scheibe M, Fradera Sola A, Butter F, De Smet C, Azzalin CM, Arnoult N, Decottignies A. PAR-TERRA is the main contributor to telomeric repeat-containing RNA transcripts in normal and cancer mouse cells. RNA. 2021 01; 27(1):106-121.
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Okoniewski SR, Uyetake L, Perkins TT. Force-activated DNA substrates for probing individual proteins interacting with single-stranded DNA. Nucleic Acids Res. 2017 Oct 13; 45(18):10775-10782.
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Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang F, Liu GH, Belmonte JC. Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science. 2015 Jun 05; 348(6239):1160-3.
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Arnoult N, Saintome C, Ourliac-Garnier I, Riou JF, Londo?o-Vallejo A. Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN. Genes Dev. 2009 Dec 15; 23(24):2915-24.
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Dixon BP, Lu L, Chu A, Bissler JJ. RecQ and RecG helicases have distinct roles in maintaining the stability of polypurine.polypyrimidine sequences. Mutat Res. 2008 Aug 25; 643(1-2):20-8.
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Rao VA, Fan AM, Meng L, Doe CF, North PS, Hickson ID, Pommier Y. Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage. Mol Cell Biol. 2005 Oct; 25(20):8925-37.
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Opresko PL, Mason PA, Podell ER, Lei M, Hickson ID, Cech TR, Bohr VA. POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J Biol Chem. 2005 Sep 16; 280(37):32069-80.
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Mandell JG, B?hler J, Volpe TA, Martienssen RA, Cech TR. Global expression changes resulting from loss of telomeric DNA in fission yeast. Genome Biol. 2005; 6(1):R1.
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Mandell JG, Goodrich KJ, B?hler J, Cech TR. Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase. J Biol Chem. 2005 Feb 18; 280(7):5249-57.
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Grandori C, Robinson KL, Galloway DA, Swisshelm K. Functional link between Myc and the Werner gene in tumorigenesis. Cell Cycle. 2004 Jan; 3(1):22-5.
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