 Spermidine
"Spermidine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and is thought to help stabilize some membranes and nucleic acid structures. It is a precursor of spermine.
| Descriptor ID |
D013095
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| MeSH Number(s) |
D02.092.211.415.701.801 D02.092.782.677
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Spermidine".
Below are MeSH descriptors whose meaning is more specific than "Spermidine".
This graph shows the total number of publications written about "Spermidine" by people in this website by year, and whether "Spermidine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 | | 2005 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2020 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 | | 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Spermidine" by people in Profiles.
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Murray KO, Maurer GS, Gioscia-Ryan RA, Zigler MC, Ludwig KR, D'Alessandro A, Reisz JA, Rossman MJ, Seals DR, Clayton ZS. The plasma metabolome is associated with preservation of physiological function following lifelong aerobic exercise in mice. Geroscience. 2024 06; 46(3):3311-3324.
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McCubbrey AL, McManus SA, McClendon JD, Thomas SM, Chatwin HB, Reisz JA, D'Alessandro A, Mould KJ, Bratton DL, Henson PM, Janssen WJ. Polyamine import and accumulation causes immunomodulation in macrophages engulfing apoptotic cells. Cell Rep. 2022 01 11; 38(2):110222.
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Chu SH, Cui J, Sparks JA, Lu B, Tedeschi SK, Speyer CB, Moss L, Feser ML, Kelmenson LB, Mewshaw EA, Edison JD, Deane KD, Clish C, Lasky-Su J, Karlson EW, Costenbader KH. Circulating plasma metabolites and risk of rheumatoid arthritis in the Nurses' Health Study. Rheumatology (Oxford). 2020 11 01; 59(11):3369-3379.
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LaRocca TJ, Gioscia-Ryan RA, Hearon CM, Seals DR. The autophagy enhancer spermidine reverses arterial aging. Mech Ageing Dev. 2013 Jul-Aug; 134(7-8):314-20.
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Walker J, Gongora R, Vasquez JJ, Drummelsmith J, Burchmore R, Roy G, Ouellette M, Gomez MA, Saravia NG. Discovery of factors linked to antimony resistance in Leishmania panamensis through differential proteome analysis. Mol Biochem Parasitol. 2012 Jun; 183(2):166-76.
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Patel MM, Anchordoquy TJ. Contribution of hydrophobicity to thermodynamics of ligand-DNA binding and DNA collapse. Biophys J. 2005 Mar; 88(3):2089-103.
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Rhodes DR, Barrette TR, Rubin MA, Ghosh D, Chinnaiyan AM. Meta-analysis of microarrays: interstudy validation of gene expression profiles reveals pathway dysregulation in prostate cancer. Cancer Res. 2002 Aug 01; 62(15):4427-33.
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Feo F, Garcea R, Daino L, Pascale R, Pirisi L, Frassetto S, Ruggiu ME. Early stimulation of polyamine biosynthesis during promotion by phenobarbital of diethylnitrosamine-induced rat liver carcinogenesis. The effects of variations of the S-adenosyl-L-methionine cellular pool. Carcinogenesis. 1985 Dec; 6(12):1713-20.
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Tanner NK, Cech TR. Self-catalyzed cyclization of the intervening sequence RNA of Tetrahymena: inhibition by methidiumpropyl.EDTA and localization of the major dye binding sites. Nucleic Acids Res. 1985 Nov 11; 13(21):7759-79.
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Olson JW, Hacker AD, Altiere RJ, Gillespie MN. Polyamines and the development of monocrotaline-induced pulmonary hypertension. Am J Physiol. 1984 Oct; 247(4 Pt 2):H682-5.
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