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Eva S Nozik

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Phone303/724-5615

    Collapse Research 
    Collapse research activities and funding
    R33HL157907     (EATON, SANDRA S.;NOZIK, EVA S.)Apr 22, 2021 - Mar 31, 2024
    NIH
    Developing EPR tools for preclinical interrogation of redox regulation mechanisms contributing to acute lung injury
    Role: Principal Investigator
    R01DK118793     (LIECHTY, KENNETH W ;NOZIK, EVA S.;SEAL, SUDIPTA)Apr 5, 2019 - Mar 31, 2024
    NIH
    Modulation of Inflammation and Oxidative Stress in Diabetic Wound Healing
    Role: Co-Principal Investigator
    R35HL139726     (NOZIK, EVA S.)Jun 1, 2018 - May 31, 2025
    NIH
    SOD3 regulation of redox sensitive signaling in pulmonary vascular diseases
    Role: Principal Investigator
    R01HL119533     (NOZIK, EVA S.)Sep 1, 2014 - Jun 30, 2019
    NIH
    miRNA Regulation of Vascular Permeability and Inflammation in the Lung Injury
    Role: Principal Investigator
    R03HL110783     (GRAYCK, EVA NOZIK)Sep 23, 2011 - Jul 31, 2014
    NIH
    DNA methylation of extracellular superoxide dismutase in pulmonary hypertension
    Role: Principal Investigator
    R01HL086680     (NOZIK, EVA S.)Dec 1, 2006 - Jul 31, 2018
    NIH
    Impact of Insufficient Vascular EC-SOD in Pulmonary Hypertension
    Role: Principal Investigator
    K08HL070088     (GRAYCK, EVA NOZIK)Apr 3, 2002 - Mar 31, 2008
    NIH
    S-nitrosylation of A -adrenergic receptors inthe lung
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Roy RM, Allawzi A, Burns N, Sul C, Rubio V, Graham J, Stenmark K, Nozik ES, Tuder RM, Vohwinkel CU. Lactate produced by alveolar type II cells suppresses inflammatory alveolar macrophages in acute lung injury. FASEB J. 2023 12; 37(12):e23316. PMID: 37983890.
      View in: PubMed
    2. Elajaili HB, Woodcock LB, Hovey TA, Rinard GA, DeGraw S, Canny A, Dee NM, Kao JPY, Nozik ES, Eaton SS, Eaton GR. Imaging Reactive Oxygen Radicals in Excised Mouse Lung Trapped by Reaction with Hydroxylamine Probes Using 1 GHz Rapid Scan Electron Paramagnetic Resonance. Mol Imaging Biol. 2023 Oct 11. PMID: 37821714.
      View in: PubMed
    3. Vaughn AE, Lehmann T, Sul C, Wallbank AM, Lyttle BD, Bardill J, Burns N, Apte A, Nozik ES, Smith B, Vohwinkel CU, Zgheib C, Liechty KW. CNP-miR146a Decreases Inflammation in Murine Acute Infectious Lung Injury. Pharmaceutics. 2023 Aug 26; 15(9). PMID: 37765178.
      View in: PubMed
    4. Elajaili HB, Dee NM, Dikalov SI, Kao JPY, Nozik ES. Use of Electron Paramagnetic Resonance (EPR) to Evaluate Redox Status in a Preclinical Model of Acute Lung Injury. Mol Imaging Biol. 2023 May 16. PMID: 37193807.
      View in: PubMed
    5. Wallbank AM, Vaughn AE, Niemiec S, Bilodeaux J, Lehmann T, Knudsen L, Kolanthai E, Seal S, Zgheib C, Nozik E, Liechty KW, Smith BJ. CNP-miR146a improves outcomes in a two-hit acute- and ventilator-induced lung injury model. Nanomedicine. 2023 06; 50:102679. PMID: 37116556.
      View in: PubMed
    6. Liang Q, Chan YC, Toscano J, Bjorkman KK, Leinwand LA, Parker R, Nozik ES, Nesbitt DJ, Ye J. Breath analysis by ultra-sensitive broadband laser spectroscopy detects SARS-CoV-2 infection. J Breath Res. 2023 04 05; 17(3). PMID: 37016829.
      View in: PubMed
    7. Sul C, Lewis C, Dee N, Burns N, Oshima K, Schmidt E, Vohwinkel C, Nozik E. Release of extracellular superoxide dismutase into alveolar fluid protects against acute lung injury and inflammation in Staphylococcus aureus pneumonia. Am J Physiol Lung Cell Mol Physiol. 2023 04 01; 324(4):L445-L455. PMID: 36749572.
      View in: PubMed
    8. Vohwinkel CU, Burns N, Coit E, Yuan X, Vladar EK, Sul C, Schmidt EP, Carmeliet P, Stenmark K, Nozik ES, Tuder RM, Eltzschig HK. HIF1A-dependent induction of alveolar epithelial PFKFB3 dampens acute lung injury. JCI Insight. 2022 12 22; 7(24). PMID: 36326834.
      View in: PubMed
    9. Sherlock LG, McCarthy WC, Grayck MR, Solar M, Hernandez A, Zheng L, Delaney C, Tipple TE, Wright CJ, Nozik ES. Neonatal Selenium Deficiency Decreases Selenoproteins in the Lung and Impairs Pulmonary Alveolar Development. Antioxidants (Basel). 2022 Dec 07; 11(12). PMID: 36552625.
      View in: PubMed
    10. Roberts DS, Sherlock LG, Posey JN, Archambault JL, Nozik ES, Delaney CA. Serotonin-deficient neonatal mice are not protected against the development of experimental bronchopulmonary dysplasia or pulmonary hypertension. Physiol Rep. 2022 10; 10(19):e15482. PMID: 36200294.
      View in: PubMed
    11. Sarkar T, Nguyen T, Moinuddin SM, Stenmark KR, Nozik ES, Saha D, Ahsan F. A Protocol for Fabrication and on-Chip Cell Culture to Recreate PAH-Afflicted Pulmonary Artery on a Microfluidic Device. Micromachines (Basel). 2022 Sep 07; 13(9). PMID: 36144106.
      View in: PubMed
    12. Ohlstrom DJ, Sul C, Vohwinkel CU, Hernandez-Lagunas L, Karimpour-Fard A, Mourani PM, Carpenter TC, Nozik ES, Sucharov CC. Plasma microRNA and metabolic changes associated with pediatric acute respiratory distress syndrome: a prospective cohort study. Sci Rep. 2022 08 26; 12(1):14560. PMID: 36028738.
      View in: PubMed
    13. Rangarajan S, Locy ML, Chanda D, Kurundkar A, Kurundkar D, Larson-Casey JL, Londono P, Bagchi RA, Deskin B, Elajaili H, Nozik ES, Deshane JS, Zmijewski JW, Eickelberg O, Thannickal VJ. Mitochondrial uncoupling protein-2 reprograms metabolism to induce oxidative stress and myofibroblast senescence in age-associated lung fibrosis. Aging Cell. 2022 09; 21(9):e13674. PMID: 35934931.
      View in: PubMed
    14. Tseng V, Collum SD, Allawzi A, Crotty K, Yeligar S, Trammell A, Ryan Smith M, Kang BY, Sutliff RL, Ingram JL, Jyothula SSSK, Thandavarayan RA, Huang HJ, Nozik ES, Wagner EJ, Michael Hart C, Karmouty-Quintana H. 3'UTR shortening of HAS2 promotes hyaluronan hyper-synthesis and bioenergetic dysfunction in pulmonary hypertension. Matrix Biol. 2022 08; 111:53-75. PMID: 35671866.
      View in: PubMed
    15. Madhavan K, Balakrishnan I, Lakshmanachetty S, Pierce A, Sanford B, Fosmire S, Elajaili HB, Walker F, Wang D, Nozik ES, Mitra SS, Dahl NA, Vibhakar R, Venkataraman S. Venetoclax Cooperates with Ionizing Radiation to Attenuate Diffuse Midline Glioma Tumor Growth. Clin Cancer Res. 2022 06 01; 28(11):2409-2424. PMID: 35344040.
      View in: PubMed
    16. Kusuyama J, Makarewicz NS, Albertson BG, Alves-Wagner AB, Conlin RH, Prince NB, Alves CRR, Ramachandran K, Kozuka C, Xiudong Y, Xia Y, Hirshman MF, Hatta T, Nagatomi R, Nozik ES, Goodyear LJ. Maternal Exercise-Induced SOD3 Reverses the Deleterious Effects of Maternal High-Fat Diet on Offspring Metabolism Through Stabilization of H3K4me3 and Protection Against WDR82 Carbonylation. Diabetes. 2022 06 01; 71(6):1170-1181. PMID: 35290440.
      View in: PubMed
    17. Elajaili H, Hernandez-Lagunas L, Harris P, Sparagna GC, Jonscher R, Ohlstrom D, Sucharov CC, Bowler RP, Suliman H, Fritz KS, Roede JR, Nozik ES. Extracellular superoxide dismutase (EC-SOD) R213G variant reduces mitochondrial ROS and preserves mitochondrial function in bleomycin-induced lung injury: EC-SOD R213G variant and intracellular redox regulation. Adv Redox Res. 2022 Jul; 5. PMID: 38273965.
      View in: PubMed
    18. Colon Hidalgo D, Elajaili H, Suliman H, George MP, Delaney C, Nozik E. Metabolism, Mitochondrial Dysfunction, and Redox Homeostasis in Pulmonary Hypertension. Antioxidants (Basel). 2022 Feb 21; 11(2). PMID: 35204311.
      View in: PubMed
    19. Soranno DE, Baker P, Kirkbride-Romeo L, Wennersten SA, Ding K, Keith B, Cavasin MA, Altmann C, Bagchi RA, Haefner KR, Montford J, Gist KM, Vergnes L, Reue K, He Z, Elajaili H, Okamura K, Nozik E, McKinsey TA, Faubel S. Female and male mice have differential longterm cardiorenal outcomes following a matched degree of ischemia-reperfusion acute kidney injury. Sci Rep. 2022 01 12; 12(1):643. PMID: 35022484.
      View in: PubMed
    20. Niemiec SM, Hilton SA, Wallbank A, Louiselle AE, Elajaili H, Hu J, Singh S, Seal S, Nozik E, Smith B, Zgheib C, Liechty KW. Lung function improves after delayed treatment with CNP-miR146a following acute lung injury. Nanomedicine. 2022 02; 40:102498. PMID: 34838994.
      View in: PubMed
    21. Ferguson BS, Wennersten SA, Demos-Davies KM, Rubino M, Robinson EL, Cavasin MA, Stratton MS, Kidger AM, Hu T, Keyse SM, McKnight RA, Lane RH, Nozik ES, Weiser-Evans MCM, McKinsey TA. DUSP5-mediated inhibition of smooth muscle cell proliferation suppresses pulmonary hypertension and right ventricular hypertrophy. Am J Physiol Heart Circ Physiol. 2021 08 01; 321(2):H382-H389. PMID: 34142888.
      View in: PubMed
    22. Vohwinkel CU, Coit EJ, Burns N, Elajaili H, Hernandez-Saavedra D, Yuan X, Eckle T, Nozik E, Tuder RM, Eltzschig HK. Targeting alveolar-specific succinate dehydrogenase A attenuates pulmonary inflammation during acute lung injury. FASEB J. 2021 04; 35(4):e21468. PMID: 33687752.
      View in: PubMed
    23. Delaney C, Davizon-Castillo P, Allawzi A, Posey J, Gandjeva A, Neeves K, Tuder RM, Di Paola J, Stenmark KR, Nozik ES. Platelet activation contributes to hypoxia-induced inflammation. Am J Physiol Lung Cell Mol Physiol. 2021 03 01; 320(3):L413-L421. PMID: 33264579.
      View in: PubMed
    24. Rao S, Kwan BM, Curtis DJ, Swanson A, Bakel LA, Bajaj L, Boguniewicz J, Lockwood JM, Ogawa K, Pemberton K, Fuhlbrigge RC, Brumbaugh D, Givens P, Nozik ES, Sills MR. Implementation of a Rapid Evidence Assessment Infrastructure during the Coronavirus Disease 2019 (COVID-19) Pandemic to Develop Policies, Clinical Pathways, Stimulate Academic Research, and Create Educational Opportunities. J Pediatr. 2021 03; 230:4-8.e2. PMID: 33091418.
      View in: PubMed
    25. Suliman HB, Nozik-Grayck E. Mitochondrial Dysfunction: Metabolic Drivers of Pulmonary Hypertension. Antioxid Redox Signal. 2019 10 20; 31(12):843-857. PMID: 30604624.
      View in: PubMed
    26. Patil MA, Upadhyay AK, Hernandez-Lagunas L, Good R, Carpenter TC, Sucharov CC, Nozik-Grayck E, Kompella UB. Targeted delivery of YSA-functionalized and non-functionalized polymeric nanoparticles to injured pulmonary vasculature. Artif Cells Nanomed Biotechnol. 2018; 46(sup3):S1059-S1066. PMID: 30450979.
      View in: PubMed
    27. Rashid J, Nozik-Grayck E, McMurtry IF, Stenmark KR, Ahsan F. Inhaled combination of sildenafil and rosiglitazone improves pulmonary hemodynamics, cardiac function, and arterial remodeling. Am J Physiol Lung Cell Mol Physiol. 2019 01 01; 316(1):L119-L130. PMID: 30307312.
      View in: PubMed
    28. Haeger SM, Liu X, Han X, McNeil JB, Oshima K, McMurtry SA, Yang Y, Ouyang Y, Zhang F, Nozik-Grayck E, Zemans RL, Tuder RM, Bastarache JA, Linhardt RJ, Schmidt EP. Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and Is Shed during Lung Injury. Am J Respir Cell Mol Biol. 2018 09; 59(3):363-374. PMID: 29584451.
      View in: PubMed
    29. Ferguson SK, Redinius K, Yalamanoglu A, Harral JW, Hyen Baek J, Pak D, Loomis Z, Hassell D, Eigenberger P, Nozik-Grayck E, Nuss R, Hassell K, Stenmark KR, Buehler PW, Irwin DC. Effects of living at moderate altitude on pulmonary vascular function and exercise capacity in mice with sickle cell anaemia. J Physiol. 2019 02; 597(4):1073-1085. PMID: 29931797.
      View in: PubMed
    30. Good RJ, Hernandez-Lagunas L, Allawzi A, Maltzahn JK, Vohwinkel CU, Upadhyay AK, Kompella UB, Birukov KG, Carpenter TC, Sucharov CC, Nozik-Grayck E. MicroRNA dysregulation in lung injury: the role of the miR-26a/EphA2 axis in regulation of endothelial permeability. Am J Physiol Lung Cell Mol Physiol. 2018 10 01; 315(4):L584-L594. PMID: 30024304.
      View in: PubMed
    31. Garcia AM, Allawzi A, Tatman P, Hernandez-Lagunas L, Swain K, Mouradian G, Bowler R, Karimpour-Fard A, Sucharov CC, Nozik-Grayck E. R213G polymorphism in SOD3 protects against bleomycin-induced inflammation and attenuates induction of proinflammatory pathways. Physiol Genomics. 2018 09 01; 50(9):807-816. PMID: 30004839.
      View in: PubMed
    32. Ni K, Gill A, Tseng V, Mikosz AM, Koike K, Beatman EL, Xu CY, Cao D, Gally F, Mould KJ, Serban KA, Schweitzer KS, March KL, Janssen WJ, Nozik-Grayck E, Garantziotis S, Petrache I. Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury. Respir Res. 2018 05 31; 19(1):107. PMID: 29855321.
      View in: PubMed
    33. Rashid J, Alobaida A, Al-Hilal TA, Hammouda S, McMurtry IF, Nozik-Grayck E, Stenmark KR, Ahsan F. Repurposing rosiglitazone, a PPAR-? agonist and oral antidiabetic, as an inhaled formulation, for the treatment of PAH. J Control Release. 2018 06 28; 280:113-123. PMID: 29723610.
      View in: PubMed
    34. El Kasmi KC, Vue PM, Anderson AL, Devereaux MW, Ghosh S, Balasubramaniyan N, Fillon SA, Dahrenmoeller C, Allawzi A, Woods C, McKenna S, Wright CJ, Johnson L, D'Alessandro A, Reisz JA, Nozik-Grayck E, Suchy FJ, Sokol RJ. Macrophage-derived IL-1?/NF-?B signaling mediates parenteral nutrition-associated cholestasis. Nat Commun. 2018 04 11; 9(1):1393. PMID: 29643332.
      View in: PubMed
    35. Sherlock LG, Trumpie A, Hernandez-Lagunas L, McKenna S, Fisher S, Bowler R, Wright CJ, Delaney C, Nozik-Grayck E. Redistribution of Extracellular Superoxide Dismutase Causes Neonatal Pulmonary Vascular Remodeling and PH but Protects Against Experimental Bronchopulmonary Dysplasia. Antioxidants (Basel). 2018 Mar 14; 7(3). PMID: 29538340.
      View in: PubMed
    36. Delaney C, Sherlock L, Fisher S, Maltzahn J, Wright C, Nozik-Grayck E. Serotonin 2A receptor inhibition protects against the development of pulmonary hypertension and pulmonary vascular remodeling in neonatal mice. Am J Physiol Lung Cell Mol Physiol. 2018 05 01; 314(5):L871-L881. PMID: 29345193.
      View in: PubMed
    37. D'Alessandro A, Nozik-Grayck E, Stenmark KR. Identification of Infants at Risk for Chronic Lung Disease at Birth. Potential for a Personalized Approach to Disease Prevention. Am J Respir Crit Care Med. 2017 10 15; 196(8):951-952. PMID: 28613077.
      View in: PubMed
    38. Mouradian GC, Gaurav R, Pugliese S, El Kasmi K, Hartman B, Hernandez-Lagunas L, Stenmark KR, Bowler RP, Nozik-Grayck E. Superoxide Dismutase 3 R213G Single-Nucleotide Polymorphism Blocks Murine Bleomycin-Induced Fibrosis and Promotes Resolution of Inflammation. Am J Respir Cell Mol Biol. 2017 03; 56(3):362-371. PMID: 27805412.
      View in: PubMed
    39. Gupta N, Rashid J, Nozik-Grayck E, McMurtry IF, Stenmark KR, Ahsan F. Cocktail of Superoxide Dismutase and Fasudil Encapsulated in Targeted Liposomes Slows PAH Progression at a Reduced Dosing Frequency. Mol Pharm. 2017 03 06; 14(3):830-841. PMID: 28165252.
      View in: PubMed
    40. Rashid J, Patel B, Nozik-Grayck E, McMurtry IF, Stenmark KR, Ahsan F. Inhaled sildenafil as an alternative to oral sildenafil in the treatment of pulmonary arterial hypertension (PAH). J Control Release. 2017 03 28; 250:96-106. PMID: 28185800.
      View in: PubMed
    41. Loomis Z, Eigenberger P, Redinius K, Lisk C, Karoor V, Nozik-Grayck E, Ferguson SK, Hassell K, Nuss R, Stenmark K, Buehler P, Irwin DC. Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation. PLoS One. 2017; 12(2):e0171219. PMID: 28152051.
      View in: PubMed
    42. Janssen WJ, Nozik-Grayck E. Power of Place: Intravascular Superoxide Dismutase for Prevention of Acute Respiratory Distress Syndrome. Am J Respir Cell Mol Biol. 2017 02; 56(2):147-149. PMID: 28145771.
      View in: PubMed
    43. Delaney C, Wright RH, Tang JR, Woods C, Villegas L, Sherlock L, Savani RC, Abman SH, Nozik-Grayck E. Lack of EC-SOD worsens alveolar and vascular development in a neonatal mouse model of bleomycin-induced bronchopulmonary dysplasia and pulmonary hypertension. Pediatr Res. 2015 Dec; 78(6):634-40. PMID: 26322414.
      View in: PubMed
    44. Irwin DC, Baek JH, Hassell K, Nuss R, Eigenberger P, Lisk C, Loomis Z, Maltzahn J, Stenmark KR, Nozik-Grayck E, Buehler PW. Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration. Free Radic Biol Med. 2015 May; 82:50-62. PMID: 25656991.
      View in: PubMed
    45. Acker SN, Seedorf GJ, Abman SH, Nozik-Grayck E, Kuhn K, Partrick DA, Gien J. Altered pulmonary artery endothelial-smooth muscle cell interactions in experimental congenital diaphragmatic hernia. Pediatr Res. 2015 Apr; 77(4):511-9. PMID: 25580737.
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    46. Nahar K, Absar S, Gupta N, Kotamraju VR, McMurtry IF, Oka M, Komatsu M, Nozik-Grayck E, Ahsan F. Peptide-coated liposomal fasudil enhances site specific vasodilation in pulmonary arterial hypertension. Mol Pharm. 2014 Dec 01; 11(12):4374-84. PMID: 25333706.
      View in: PubMed
    47. Marriott S, Baskir RS, Gaskill C, Menon S, Carrier EJ, Williams J, Talati M, Helm K, Alford CE, Kropski JA, Loyd J, Wheeler L, Johnson J, Austin E, Nozik-Grayck E, Meyrick B, West JD, Klemm DJ, Majka SM. ABCG2pos lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling. Am J Physiol Cell Physiol. 2014 Oct 15; 307(8):C684-98. PMID: 25122876.
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    48. Hartney JM, Stidham T, Goldstrohm DA, Oberley-Deegan RE, Weaver MR, Valnickova-Hansen Z, Scavenius C, Benninger RK, Leahy KF, Johnson R, Gally F, Kosmider B, Zimmermann AK, Enghild JJ, Nozik-Grayck E, Bowler RP. A common polymorphism in extracellular superoxide dismutase affects cardiopulmonary disease risk by altering protein distribution. Circ Cardiovasc Genet. 2014 Oct; 7(5):659-66. PMID: 25085920.
      View in: PubMed
    49. Villegas L, Stidham T, Nozik-Grayck E. Oxidative Stress and Therapeutic Development in Lung Diseases. J Pulm Respir Med. 2014 Aug; 4(4). PMID: 27019769.
      View in: PubMed
    50. Lisk C, Kominsky D, Ehrentraut S, Bonaventura J, Nuss R, Hassell K, Nozik-Grayck E, Irwin DC. Hemoglobin-induced endothelial cell permeability is controlled, in part, via a myeloid differentiation primary response gene-88-dependent signaling mechanism. Am J Respir Cell Mol Biol. 2013 Oct; 49(4):619-26. PMID: 23713977.
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    51. Lisk C, McCord J, Bose S, Sullivan T, Loomis Z, Nozik-Grayck E, Schroeder T, Hamilton K, Irwin DC. Nrf2 activation: a potential strategy for the prevention of acute mountain sickness. Free Radic Biol Med. 2013 Oct; 63:264-73. PMID: 23722164.
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    52. Gupta V, Gupta N, Shaik IH, Mehvar R, Nozik-Grayck E, McMurtry IF, Oka M, Komatsu M, Ahsan F. Inhaled PLGA particles of prostaglandin E1 ameliorate symptoms and progression of pulmonary hypertension at a reduced dosing frequency. Mol Pharm. 2013 May 06; 10(5):1655-67. PMID: 23485062.
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    53. Tang JR, Michaelis KA, Nozik-Grayck E, Seedorf GJ, Hartman-Filson M, Abman SH, Wright CJ. The NF-?B inhibitory proteins I?Ba and I?B? mediate disparate responses to inflammation in fetal pulmonary endothelial cells. J Immunol. 2013 Mar 15; 190(6):2913-23. PMID: 23418625.
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    54. Villegas LR, Kluck D, Field C, Oberley-Deegan RE, Woods C, Yeager ME, El Kasmi KC, Savani RC, Bowler RP, Nozik-Grayck E. Superoxide dismutase mimetic, MnTE-2-PyP, attenuates chronic hypoxia-induced pulmonary hypertension, pulmonary vascular remodeling, and activation of the NALP3 inflammasome. Antioxid Redox Signal. 2013 May 10; 18(14):1753-64. PMID: 23240585.
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    55. Gupta V, Gupta N, Shaik IH, Mehvar R, McMurtry IF, Oka M, Nozik-Grayck E, Komatsu M, Ahsan F. Liposomal fasudil, a rho-kinase inhibitor, for prolonged pulmonary preferential vasodilation in pulmonary arterial hypertension. J Control Release. 2013 Apr 28; 167(2):189-99. PMID: 23353807.
      View in: PubMed
    56. Chow K, Fessel JP, Schmidt EP, Gaskill C, Alvarez D, Graham B, Harrison DG, Wagner DH, Nozik-Grayck E, West JD, Klemm DJ, Majka SM. Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling. Pulm Circ. 2013 Jan; 3(1):31-49. PMID: 23662173.
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    57. Stenmark KR, Yeager ME, El Kasmi KC, Nozik-Grayck E, Gerasimovskaya EV, Li M, Riddle SR, Frid MG. The adventitia: essential regulator of vascular wall structure and function. Annu Rev Physiol. 2013; 75:23-47. PMID: 23216413.
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    58. Buehler PW, Baek JH, Lisk C, Connor I, Sullivan T, Kominsky D, Majka S, Stenmark KR, Nozik-Grayck E, Bonaventura J, Irwin DC. Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism. Am J Physiol Lung Cell Mol Physiol. 2012 Aug 15; 303(4):L312-26. PMID: 22728465.
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    59. Hartney T, Birari R, Venkataraman S, Villegas L, Martinez M, Black SM, Stenmark KR, Nozik-Grayck E. Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia. PLoS One. 2011; 6(11):e27531. PMID: 22140445.
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    60. Majka S, Hagen M, Blackwell T, Harral J, Johnson JA, Gendron R, Paradis H, Crona D, Loyd JE, Nozik-Grayck E, Stenmark KR, West J. Physiologic and molecular consequences of endothelial Bmpr2 mutation. Respir Res. 2011 Jun 22; 12:84. PMID: 21696628.
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    61. Jun D, Garat C, West J, Thorn N, Chow K, Cleaver T, Sullivan T, Torchia EC, Childs C, Shade T, Tadjali M, Lara A, Nozik-Grayck E, Malkoski S, Sorrentino B, Meyrick B, Klemm D, Rojas M, Wagner DH, Majka SM. The pathology of bleomycin-induced fibrosis is associated with loss of resident lung mesenchymal stem cells that regulate effector T-cell proliferation. Stem Cells. 2011 Apr; 29(4):725-35. PMID: 21312316.
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    62. Goodman DM, Winkler MK, Fiser RT, Abd-Allah S, Mathur M, Rivero N, Weiss IK, Peterson B, Cornfield DN, Mink R, Nozik Grayck E, McCabe ME, Schuette J, Nares MA, Totapally B, Petrillo-Albarano T, Wolfson RK, Moreland JG, Potter KE, Fackler J, Garber N, Burns JP, Shanley TP, Lieh-Lai MW, Steiner M, Tieves KS, Goldsmith M, Asuncion A, Ross SL, Howell JD, Biagas K, Ognibene K, Joshi P, Rubenstein JS, Kocis KC, Cheifetz IM, Turner DA, Doughty L, Hall MW, Mason K, Penfil S, Morrison W, Hoehn KS, Watson RS, Garcia RL, Storgion SA, Fleming GM, Castillo L, Tcharmtchi MH, Taylor RP, Ul Haque I, Crain N, Baden HP, Lee KJ. The Accreditation Council for Graduate Medical Education proposed work hour regulations. Pediatr Crit Care Med. 2011 Jan; 12(1):120-1. PMID: 21209582.
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    63. Stenmark KR, Nozik-Grayck E, Gerasimovskaya E, Anwar A, Li M, Riddle S, Frid M. The adventitia: Essential role in pulmonary vascular remodeling. Compr Physiol. 2011 Jan; 1(1):141-61. PMID: 23737168.
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    64. Clarke MB, Wright R, Irwin D, Bose S, Van Rheen Z, Birari R, Stenmark KR, McCord JM, Nozik-Grayck E. Sustained lung activity of a novel chimeric protein, SOD2/3, after intratracheal administration. Free Radic Biol Med. 2010 Dec 15; 49(12):2032-9. PMID: 20932897.
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    65. Van Rheen Z, Fattman C, Domarski S, Majka S, Klemm D, Stenmark KR, Nozik-Grayck E. Lung extracellular superoxide dismutase overexpression lessens bleomycin-induced pulmonary hypertension and vascular remodeling. Am J Respir Cell Mol Biol. 2011 Apr; 44(4):500-8. PMID: 20539010.
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    66. Nozik ES, Huang YC, Piantadosi CA. L-arginine enhances injury in the isolated rabbit lung during hyperoxia. Respir Physiol. 1995 Apr; 100(1):63-74. PMID: 7541544.
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    67. Huang YC, Nozik ES, Piantadosi CA. Superoxide dismutase potentiates platelet-activating factor-induced injury in perfused lung. Am J Physiol. 1994 Mar; 266(3 Pt 1):L246-54. PMID: 7513130.
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    68. MacInnes JI, Nozik ES, Kurtz DT. Tissue-specific expression of the rat alpha 2u globulin gene family. Mol Cell Biol. 1986 Oct; 6(10):3563-7. PMID: 2432391.
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