 Cardiomegaly
"Cardiomegaly" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Descriptor ID |
D006332
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| MeSH Number(s) |
C14.280.195 C23.300.775.250
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| Concept/Terms |
Cardiomegaly- Cardiomegaly
- Heart Enlargement
- Enlargement, Heart
- Enlarged Heart
- Heart, Enlarged
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Below are MeSH descriptors whose meaning is more general than "Cardiomegaly".
Below are MeSH descriptors whose meaning is more specific than "Cardiomegaly".
This graph shows the total number of publications written about "Cardiomegaly" by people in this website by year, and whether "Cardiomegaly" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 1 | 2 | | 1997 | 2 | 2 | 4 | | 1998 | 1 | 0 | 1 | | 1999 | 1 | 0 | 1 | | 2000 | 1 | 2 | 3 | | 2001 | 5 | 0 | 5 | | 2002 | 2 | 5 | 7 | | 2003 | 2 | 2 | 4 | | 2004 | 3 | 3 | 6 | | 2005 | 1 | 1 | 2 | | 2006 | 5 | 1 | 6 | | 2007 | 5 | 0 | 5 | | 2008 | 1 | 2 | 3 | | 2009 | 1 | 1 | 2 | | 2010 | 1 | 6 | 7 | | 2011 | 2 | 1 | 3 | | 2012 | 4 | 0 | 4 | | 2013 | 5 | 2 | 7 | | 2014 | 2 | 1 | 3 | | 2015 | 3 | 0 | 3 | | 2016 | 4 | 2 | 6 | | 2017 | 3 | 1 | 4 | | 2018 | 2 | 1 | 3 | | 2020 | 4 | 1 | 5 | | 2022 | 0 | 2 | 2 | | 2023 | 0 | 3 | 3 | | 2024 | 2 | 2 | 4 | | 2025 | 4 | 0 | 4 |
To return to the timeline, click here.
Below are the most recent publications written about "Cardiomegaly" by people in Profiles.
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Vaughan OR, Goodspeed A, Sucharov CC, Powell TL, Jansson T. Human fetal circulating factors from pregnancies complicated by obesity upregulate genes associated with pathological hypertrophy in neonatal rat cardiomyocytes. Am J Physiol Heart Circ Physiol. 2026 Jan 01; 330(1):H124-H136.
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Hok KD, Rich HE, Shadid A, Gunamalai L, Weng-Mills T, Thandavarayan RA, Banda NK, Doursout MF, Restrepo MI, Shivshankar P. Functional Roles of the Complement Immune System in Cardiac Inflammation and Hypertrophy. Int J Mol Sci. 2025 Oct 12; 26(20).
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Martin TG, Langer SJ, Crocini C, Chung E, Leinwand LA. Activation of FoxO1 prevents and reverses cardiac hypertrophy from diverse stimuli. J Mol Cell Cardiol. 2025 Aug; 205:62-67.
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Eggertsen TG, Travers JG, Hardy EJ, Wolf MJ, McKinsey TA, Saucerman JJ. Logic-based machine learning predicts how escitalopram attenuates cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A. 2025 Mar 11; 122(10):e2420499122.
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Akumwami S, Kitada K, Fujisawa Y, Kundo NK, Rahman MM, Morishita A, Kitamura H, Rahman A, Ogino Y, Nishiyama A. Chronic activation of ß-adrenergic receptors leads to tissue water and electrolyte retention. J Pharmacol Exp Ther. 2025 Feb; 392(2):100017.
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Martin TG, Leinwand LA. Molecular regulation of reversible cardiac remodeling: lessons from species with extreme physiological adaptations. J Exp Biol. 2024 10 15; 227(20).
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Crocini C, Woulfe KC, Ozeroff CD, Perni S, Cardiello J, Walker CJ, Wilson CE, Anseth K, Allen MA, Leinwand LA. Postprandial cardiac hypertrophy is sustained by mechanics, epigenetic, and metabolic reprogramming in pythons. Proc Natl Acad Sci U S A. 2024 Sep 03; 121(36):e2322726121.
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Akumwami S, Rahman A, Funamoto M, Hossain A, Morishita A, Ikeda Y, Kitamura H, Kitada K, Noma T, Ogino Y, Nishiyama A. Effects of D-Allose on experimental cardiac hypertrophy. J Pharmacol Sci. 2024 Oct; 156(2):142-148.
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Baldwin TA, Teuber JP, Kuwabara Y, Subramani A, Lin SJ, Kanisicak O, Vagnozzi RJ, Zhang W, Brody MJ, Molkentin JD. Palmitoylation-dependent regulation of cardiomyocyte Rac1 signaling activity and minor effects on cardiac hypertrophy. J Biol Chem. 2023 12; 299(12):105426.
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Bowers SLK, Meng Q, Kuwabara Y, Huo J, Minerath R, York AJ, Sargent MA, Prasad V, Saviola AJ, Galindo DC, Hansen KC, Vagnozzi RJ, Yutzey KE, Molkentin JD. Col1a2-Deleted Mice Have Defective Type I Collagen and Secondary Reactive Cardiac Fibrosis with Altered Hypertrophic Dynamics. Cells. 2023 08 30; 12(17).
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