 Cardiomegaly
"Cardiomegaly" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Descriptor ID |
D006332
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| MeSH Number(s) |
C14.280.195 C23.300.775.250
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| Concept/Terms |
Cardiomegaly- Cardiomegaly
- Heart Enlargement
- Enlargement, Heart
- Enlarged Heart
- Heart, Enlarged
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Below are MeSH descriptors whose meaning is more general than "Cardiomegaly".
Below are MeSH descriptors whose meaning is more specific than "Cardiomegaly".
This graph shows the total number of publications written about "Cardiomegaly" by people in this website by year, and whether "Cardiomegaly" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 1 | 2 | | 1996 | 1 | 1 | 2 | | 1997 | 2 | 2 | 4 | | 1998 | 1 | 1 | 2 | | 1999 | 1 | 0 | 1 | | 2000 | 1 | 3 | 4 | | 2001 | 5 | 0 | 5 | | 2002 | 1 | 3 | 4 | | 2003 | 2 | 2 | 4 | | 2004 | 3 | 3 | 6 | | 2005 | 1 | 1 | 2 | | 2006 | 4 | 1 | 5 | | 2007 | 5 | 0 | 5 | | 2008 | 2 | 2 | 4 | | 2009 | 1 | 1 | 2 | | 2010 | 1 | 7 | 8 | | 2011 | 2 | 1 | 3 | | 2012 | 4 | 0 | 4 | | 2013 | 5 | 2 | 7 | | 2014 | 2 | 1 | 3 | | 2015 | 3 | 0 | 3 | | 2016 | 2 | 2 | 4 | | 2017 | 3 | 1 | 4 | | 2018 | 2 | 1 | 3 | | 2020 | 3 | 1 | 4 | | 2022 | 0 | 2 | 2 | | 2023 | 0 | 3 | 3 |
To return to the timeline, click here.
Below are the most recent publications written about "Cardiomegaly" by people in Profiles.
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Baldwin TA, Teuber JP, Kuwabara Y, Subramani A, Lin SJ, Kanisicak O, Vagnozzi RJ, Zhang W, Brody MJ, Molkentin JD. Palmitoylation-dependent regulation of cardiomyocyte Rac1 signaling activity and minor effects on cardiac hypertrophy. J Biol Chem. 2023 12; 299(12):105426.
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Bowers SLK, Meng Q, Kuwabara Y, Huo J, Minerath R, York AJ, Sargent MA, Prasad V, Saviola AJ, Galindo DC, Hansen KC, Vagnozzi RJ, Yutzey KE, Molkentin JD. Col1a2-Deleted Mice Have Defective Type I Collagen and Secondary Reactive Cardiac Fibrosis with Altered Hypertrophic Dynamics. Cells. 2023 08 30; 12(17).
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Martin TG, Juarros MA, Leinwand LA. Regression of cardiac hypertrophy in health and disease: mechanisms and therapeutic potential. Nat Rev Cardiol. 2023 05; 20(5):347-363.
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Vaughan OR, Rosario FJ, Chan J, Cox LA, Ferchaud-Roucher V, Zemski-Berry KA, Reusch JEB, Keller AC, Powell TL, Jansson T. Maternal obesity causes fetal cardiac hypertrophy and alters adult offspring myocardial metabolism in mice. J Physiol. 2022 07; 600(13):3169-3191.
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Li H, Trager LE, Liu X, Hastings MH, Xiao C, Guerra J, To S, Li G, Yeri A, Rodosthenous R, Silverman MG, Das S, Ambardekar AV, Bristow MR, Gonz?lez-Rosa JM, Rosenzweig A. lncExACT1 and DCHS2 Regulate Physiological and Pathological Cardiac Growth. Circulation. 2022 04 19; 145(16):1218-1233.
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Coleman RC, Eguchi A, Lieu M, Roy R, Barr EW, Ibetti J, Lucchese AM, Peluzzo AM, Gresham K, Chuprun JK, Koch WJ. A peptide of the N terminus of GRK5 attenuates pressure-overload hypertrophy and heart failure. Sci Signal. 2021 03 30; 14(676).
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Ceccato TL, Starbuck RB, Hall JK, Walker CJ, Brown TE, Killgore JP, Anseth KS, Leinwand LA. Defining the Cardiac Fibroblast Secretome in a Fibrotic Microenvironment. J Am Heart Assoc. 2020 10 20; 9(19):e017025.
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Woulfe KC, Travers JG, McKinsey TA. A Phosphatase Anchor Weighs on the Heart. Circulation. 2020 09 08; 142(10):963-966.
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Atwood DJ, Pokhrel D, Brown CN, Holditch SJ, Bachu DM, Thorburn A, Hopp K, Edelstein CL. Increased mTOR and suppressed autophagic flux in the heart of a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease. Cell Signal. 2020 10; 74:109730.
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Pfleger J, Coleman RC, Ibetti J, Roy R, Kyriazis ID, Gao E, Drosatos K, Koch WJ. Genomic Binding Patterns of Forkhead Box Protein O1 Reveal Its Unique Role in Cardiac Hypertrophy. Circulation. 2020 09; 142(9):882-898.
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