 Fatty Acid Synthase, Type I
"Fatty Acid Synthase, Type I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Animal form of fatty acid synthase which is encoded by a single gene and consists of seven catalytic domains and is functional as a homodimer. It is overexpressed in some NEOPLASMS and is a target in humans of some ANTINEOPLASTIC AGENTS and some ANTI-OBESITY AGENTS.
| Descriptor ID |
D054890
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| MeSH Number(s) |
D08.811.277.352.897.387.100 D08.811.520.241.300.287.099 D08.811.641.758 D08.811.682.047.820.196.500.099 D08.811.913.050.134.029.500.100 D08.811.913.050.170.500.100
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Fatty Acid Synthase, Type I".
Below are MeSH descriptors whose meaning is more specific than "Fatty Acid Synthase, Type I".
This graph shows the total number of publications written about "Fatty Acid Synthase, Type I" by people in this website by year, and whether "Fatty Acid Synthase, Type I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 2 | 0 | 2 | | 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Fatty Acid Synthase, Type I" by people in Profiles.
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Du T, Sikora MJ, Levine KM, Tasdemir N, Riggins RB, Wendell SG, Van Houten B, Oesterreich S. Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer. Breast Cancer Res. 2018 09 04; 20(1):106.
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Wahdan-Alaswad RS, Cochrane DR, Spoelstra NS, Howe EN, Edgerton SM, Anderson SM, Thor AD, Richer JK. Metformin-induced killing of triple-negative breast cancer cells is mediated by reduction in fatty acid synthase via miRNA-193b. Horm Cancer. 2014 Dec; 5(6):374-89.
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Wellberg EA, Anderson SM. FASNating targets of metformin in breast cancer stem-like cells. Horm Cancer. 2014 Dec; 5(6):358-62.
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Rudolph MC, Wellberg EA, Lewis AS, Terrell KL, Merz AL, Maluf NK, Serkova NJ, Anderson SM. Thyroid hormone responsive protein Spot14 enhances catalysis of fatty acid synthase in lactating mammary epithelium. J Lipid Res. 2014 06; 55(6):1052-65.
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Rudolph MC, Karl Maluf N, Wellberg EA, Johnson CA, Murphy RC, Anderson SM. Mammalian fatty acid synthase activity from crude tissue lysates tracing ??C-labeled substrates using gas chromatography-mass spectrometry. Anal Biochem. 2012 Sep 15; 428(2):158-66.
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