 Phosphofructokinase-2
"Phosphofructokinase-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.
| Descriptor ID |
D025481
|
| MeSH Number(s) |
D08.811.277.352.650.622 D08.811.641.843 D08.811.913.696.620.225.850.750
|
| Concept/Terms |
Phosphofructokinase-2- Phosphofructokinase-2
- Phosphofructokinase 2
- ATP-D-Fructose-6-phosphate 2-phosphotransferase
- 6-Phosphofructo-2-kinase
- Fructose-6-P,2-kinase
- Fructose-6-phosphate,2-kinase
- 6PF2K
- Fru-6-P,2-kinase
Fructose-2,6-bisphosphatase- Fructose-2,6-bisphosphatase
- Fructose-2,6-bisphosphate 2-phosphatase
- fructose-2,6-diphosphatase
- Fructose 2,6-bisphosphatase
6-Phosphofructo-2-kinase-fructose-2,6-bisphosphatase- 6-Phosphofructo-2-kinase-fructose-2,6-bisphosphatase
- 6-Phosphofructo 2-kinase-fructose 2,6-bisphosphatase
- Fructose-6-phosphate,2-kinase-fructose-2,6-bisphosphatase
- 6-PF-2-K-Fru-2,6-P(2)ase
- F Kinase-F-bisphosphatase
- Fru-kinase-Fru-bisphosphatase
|
Below are MeSH descriptors whose meaning is more general than "Phosphofructokinase-2".
Below are MeSH descriptors whose meaning is more specific than "Phosphofructokinase-2".
This graph shows the total number of publications written about "Phosphofructokinase-2" by people in this website by year, and whether "Phosphofructokinase-2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 | | 2021 | 1 | 0 | 1 | | 2022 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Phosphofructokinase-2" by people in Profiles.
-
Vohwinkel CU, Burns N, Coit E, Yuan X, Vladar EK, Sul C, Schmidt EP, Carmeliet P, Stenmark K, Nozik ES, Tuder RM, Eltzschig HK. HIF1A-dependent induction of alveolar epithelial PFKFB3 dampens acute lung injury. JCI Insight. 2022 12 22; 7(24).
-
Kassa B, Kumar R, Mickael C, Sanders L, Vohwinkel C, Lee MH, Gu S, Poth JM, Stenmark KR, Zhao YY, Tuder RM, Graham BB. Endothelial cell PHD2-HIF1a-PFKFB3 contributes to right ventricle vascular adaptation in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2021 10 01; 321(4):L675-L685.
-
Chang HH, Liu GY, Dwivedi N, Sun B, Okamoto Y, Kinslow JD, Deane KD, Demoruelle MK, Norris JM, Thompson PR, Sparks JA, Rao DA, Karlson EW, Hung HC, Holers VM, Ho IC. A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22. JCI Insight. 2016 Oct 20; 1(17):e90045.
-
Kommagani R, Szwarc MM, Kovanci E, Gibbons WE, Putluri N, Maity S, Creighton CJ, Sreekumar A, DeMayo FJ, Lydon JP, O'Malley BW. Acceleration of the glycolytic flux by steroid receptor coactivator-2 is essential for endometrial decidualization. PLoS Genet. 2013 Oct; 9(10):e1003900.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|