 Calcineurin
"Calcineurin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
| Descriptor ID |
D019703
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| MeSH Number(s) |
D08.811.277.352.650.625.150 D12.644.360.087 D12.776.476.087
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| Concept/Terms |
Calcineurin- Calcineurin
- Protein Phosphatase 3
- Phosphatase 3, Protein
- Protein Phosphatase-2B
- Protein Phosphatase 2B
Calcineurin B- Calcineurin B
- Protein Phosphatase 3 Regulatory Subunit
Calcineurin A- Calcineurin A
- Protein Phosphatase 3 Catalytic Subunit
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Below are MeSH descriptors whose meaning is more general than "Calcineurin".
Below are MeSH descriptors whose meaning is more specific than "Calcineurin".
This graph shows the total number of publications written about "Calcineurin" by people in this website by year, and whether "Calcineurin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 2 | 2 | 4 | | 2001 | 1 | 4 | 5 | | 2002 | 6 | 2 | 8 | | 2003 | 1 | 2 | 3 | | 2004 | 1 | 5 | 6 | | 2005 | 1 | 5 | 6 | | 2006 | 2 | 2 | 4 | | 2007 | 1 | 1 | 2 | | 2008 | 0 | 2 | 2 | | 2009 | 1 | 1 | 2 | | 2010 | 0 | 2 | 2 | | 2012 | 5 | 2 | 7 | | 2013 | 1 | 1 | 2 | | 2014 | 1 | 1 | 2 | | 2015 | 1 | 1 | 2 | | 2016 | 1 | 1 | 2 | | 2017 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 | | 2019 | 2 | 1 | 3 |
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Below are the most recent publications written about "Calcineurin" by people in Profiles.
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Ronan PJ, Flynn SA, Beresford TP. Calcineurin signaling as a target for the treatment of alcohol abuse and neuroinflammatory disorders. Prog Mol Biol Transl Sci. 2019; 167:125-142.
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Rabe JL, Gardner L, Hunter R, Fonseca JA, Dougan J, Gearheart CM, Leibowitz MS, Lee-Miller C, Baturin D, Fosmire SP, Zelasko SE, Jones CL, Slansky JE, Rupji M, Dwivedi B, Henry CJ, Porter CC. IL12 Abrogates Calcineurin-Dependent Immune Evasion during Leukemia Progression. Cancer Res. 2019 07 15; 79(14):3702-3713.
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Murphy JG, Crosby KC, Dittmer PJ, Sather WA, Dell'Acqua ML. AKAP79/150 recruits the transcription factor NFAT to regulate signaling to the nucleus by neuronal L-type Ca2+ channels. Mol Biol Cell. 2019 07 01; 30(14):1743-1756.
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Ronan PJ, Strait SA, Palmer GM, Beresford TP. Central Administration of Cyclosporine A Decreases Ethanol Drinking. Alcohol Alcohol. 2018 Mar 01; 53(2):193-199.
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Sompol P, Furman JL, Pleiss MM, Kraner SD, Artiushin IA, Batten SR, Quintero JE, Simmerman LA, Beckett TL, Lovell MA, Murphy MP, Gerhardt GA, Norris CM. Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aß-Bearing Mice. J Neurosci. 2017 06 21; 37(25):6132-6148.
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Li L, Li J, Drum BM, Chen Y, Yin H, Guo X, Luckey SW, Gilbert ML, McKnight GS, Scott JD, Santana LF, Liu Q. Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve. Cardiovasc Res. 2017 02; 113(2):147-159.
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Sanderson JL, Gorski JA, Dell'Acqua ML. NMDA Receptor-Dependent LTD Requires Transient Synaptic Incorporation of Ca²?-Permeable AMPARs Mediated by AKAP150-Anchored PKA and Calcineurin. Neuron. 2016 Mar 02; 89(5):1000-15.
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Nieves-Cintrón M, Hirenallur-Shanthappa D, Nygren PJ, Hinke SA, Dell'Acqua ML, Langeberg LK, Navedo M, Santana LF, Scott JD. AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction. Cell Signal. 2016 07; 28(7):733-40.
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Piccart E, Courtney NA, Branch SY, Ford CP, Beckstead MJ. Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. J Neurosci. 2015 Aug 05; 35(31):11144-52.
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Dittmer PJ, Dell'Acqua ML, Sather WA. Ca2+/calcineurin-dependent inactivation of neuronal L-type Ca2+ channels requires priming by AKAP-anchored protein kinase A. Cell Rep. 2014 Jun 12; 7(5):1410-1416.
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