 Calcineurin
"Calcineurin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
| Descriptor ID |
D019703
|
| MeSH Number(s) |
D08.811.277.352.650.625.150 D12.644.360.087 D12.776.476.087
|
| Concept/Terms |
Calcineurin- Calcineurin
- Protein Phosphatase 3
- Phosphatase 3, Protein
- Protein Phosphatase-2B
- Protein Phosphatase 2B
Calcineurin B- Calcineurin B
- Protein Phosphatase 3 Regulatory Subunit
Calcineurin A- Calcineurin A
- Protein Phosphatase 3 Catalytic Subunit
|
Below are MeSH descriptors whose meaning is more general than "Calcineurin".
Below are MeSH descriptors whose meaning is more specific than "Calcineurin".
This graph shows the total number of publications written about "Calcineurin" by people in this website by year, and whether "Calcineurin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 2 | 2 | 4 | | 2001 | 1 | 4 | 5 | | 2002 | 6 | 2 | 8 | | 2003 | 1 | 2 | 3 | | 2004 | 1 | 5 | 6 | | 2005 | 1 | 5 | 6 | | 2006 | 2 | 2 | 4 | | 2007 | 1 | 1 | 2 | | 2008 | 0 | 1 | 1 | | 2009 | 1 | 1 | 2 | | 2010 | 0 | 2 | 2 | | 2012 | 5 | 2 | 7 | | 2013 | 1 | 1 | 2 | | 2014 | 1 | 1 | 2 | | 2015 | 1 | 1 | 2 | | 2016 | 1 | 1 | 2 | | 2017 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 | | 2019 | 2 | 2 | 4 | | 2020 | 0 | 1 | 1 | | 2021 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Calcineurin" by people in Profiles.
-
Stewart S, Le Bleu HK, Yette GA, Henner AL, Robbins AE, Braunstein JA, Stankunas K. longfin causes cis-ectopic expression of the kcnh2a ether-a-go-go K+ channel to autonomously prolong fin outgrowth. Development. 2021 06 01; 148(11).
-
Rajgor D, Purkey AM, Sanderson JL, Welle TM, Garcia JD, Dell'Acqua ML, Smith KR. Local miRNA-Dependent Translational Control of GABAAR Synthesis during Inhibitory Long-Term Potentiation. Cell Rep. 2020 06 23; 31(12):107785.
-
Ronan PJ, Flynn SA, Beresford TP. Calcineurin signaling as a target for the treatment of alcohol abuse and neuroinflammatory disorders. Prog Mol Biol Transl Sci. 2019; 167:125-142.
-
Dietz RM, Cruz-Torres I, Orfila JE, Patsos OP, Shimizu K, Chalmers N, Deng G, Tiemeier E, Quillinan N, Herson PS. Reversal of Global Ischemia-Induced Cognitive Dysfunction by Delayed Inhibition of TRPM2 Ion Channels. Transl Stroke Res. 2020 04; 11(2):254-266.
-
Rabe JL, Gardner L, Hunter R, Fonseca JA, Dougan J, Gearheart CM, Leibowitz MS, Lee-Miller C, Baturin D, Fosmire SP, Zelasko SE, Jones CL, Slansky JE, Rupji M, Dwivedi B, Henry CJ, Porter CC. IL12 Abrogates Calcineurin-Dependent Immune Evasion during Leukemia Progression. Cancer Res. 2019 07 15; 79(14):3702-3713.
-
Murphy JG, Crosby KC, Dittmer PJ, Sather WA, Dell'Acqua ML. AKAP79/150 recruits the transcription factor NFAT to regulate signaling to the nucleus by neuronal L-type Ca2+ channels. Mol Biol Cell. 2019 07 01; 30(14):1743-1756.
-
Ronan PJ, Strait SA, Palmer GM, Beresford TP. Central Administration of Cyclosporine A Decreases Ethanol Drinking. Alcohol Alcohol. 2018 Mar 01; 53(2):193-199.
-
Sompol P, Furman JL, Pleiss MM, Kraner SD, Artiushin IA, Batten SR, Quintero JE, Simmerman LA, Beckett TL, Lovell MA, Murphy MP, Gerhardt GA, Norris CM. Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aß-Bearing Mice. J Neurosci. 2017 06 21; 37(25):6132-6148.
-
Li L, Li J, Drum BM, Chen Y, Yin H, Guo X, Luckey SW, Gilbert ML, McKnight GS, Scott JD, Santana LF, Liu Q. Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve. Cardiovasc Res. 2017 02; 113(2):147-159.
-
Sanderson JL, Gorski JA, Dell'Acqua ML. NMDA Receptor-Dependent LTD Requires Transient Synaptic Incorporation of Ca²?-Permeable AMPARs Mediated by AKAP150-Anchored PKA and Calcineurin. Neuron. 2016 Mar 02; 89(5):1000-15.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|