 Calcium Channels, L-Type
"Calcium Channels, L-Type" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
| Descriptor ID |
D020746
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| MeSH Number(s) |
D12.776.157.530.400.150.400 D12.776.543.550.450.150.400 D12.776.543.585.400.150.400
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| Concept/Terms |
Calcium Channels, L-Type- Calcium Channels, L-Type
- Calcium Channels, L Type
- L-Type VDCC
- L Type VDCC
- VDCC, L-Type
- L-Type Calcium Channel
- Calcium Channel, L-Type
- L Type Calcium Channel
- L-Type Voltage-Dependent Calcium Channels
- L Type Voltage Dependent Calcium Channels
- L-Type Calcium Channels
- L Type Calcium Channels
- Long-Lasting Calcium Channels
- Calcium Channels, Long-Lasting
- Long Lasting Calcium Channels
Receptors, Dihydropyridine- Receptors, Dihydropyridine
- L-Type VDCC alpha-1 Subunit
- L Type VDCC alpha 1 Subunit
- Dihydropyridine Receptor
- Receptor, Dihydropyridine
- Dihydropyridine Receptors
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Below are MeSH descriptors whose meaning is more general than "Calcium Channels, L-Type".
Below are MeSH descriptors whose meaning is more specific than "Calcium Channels, L-Type".
This graph shows the total number of publications written about "Calcium Channels, L-Type" by people in this website by year, and whether "Calcium Channels, L-Type" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 0 | 1 | 1 | | 1996 | 0 | 3 | 3 | | 1997 | 0 | 3 | 3 | | 1998 | 0 | 3 | 3 | | 1999 | 0 | 2 | 2 | | 2000 | 1 | 2 | 3 | | 2001 | 3 | 2 | 5 | | 2002 | 1 | 1 | 2 | | 2003 | 3 | 1 | 4 | | 2004 | 1 | 3 | 4 | | 2005 | 1 | 1 | 2 | | 2006 | 0 | 2 | 2 | | 2007 | 2 | 0 | 2 | | 2008 | 3 | 4 | 7 | | 2009 | 4 | 0 | 4 | | 2010 | 5 | 1 | 6 | | 2011 | 1 | 0 | 1 | | 2012 | 5 | 1 | 6 | | 2013 | 1 | 0 | 1 | | 2014 | 5 | 2 | 7 | | 2015 | 1 | 0 | 1 | | 2016 | 2 | 2 | 4 | | 2017 | 3 | 2 | 5 | | 2018 | 2 | 0 | 2 | | 2019 | 3 | 1 | 4 | | 2022 | 2 | 1 | 3 | | 2024 | 1 | 0 | 1 | | 2025 | 2 | 1 | 3 |
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Below are the most recent publications written about "Calcium Channels, L-Type" by people in Profiles.
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Bernard PB, Castano AM, Buonarati OR, Camp CR, Hell JW, Benke TA. Early life seizures chronically disrupt L-type voltage gated calcium channel regulation of mGluR mediated long term depression via interactions with protein phosphatase 2A. Neurobiol Dis. 2025 06 01; 209:106884.
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Tadic VP, Timic Stamenic T, Todorovic SM. CaV2.3 channels in the mouse central medial thalamic nucleus are essential for thalamocortical oscillations and spike wave discharges. Sci Rep. 2025 Feb 10; 15(1):4966.
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Zent KH, Dell'Acqua ML. Synapse-to-Nucleus ERK?CREB Transcriptional Signaling Requires Dendrite-to-Soma Ca2+ Propagation Mediated by L-Type Voltage-Gated Ca2+ Channels. J Neurosci. 2025 Jan 22; 45(4).
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Dittmer PJ, Dell'Acqua ML. L-type Ca2+ channel activation of STIM1-Orai1 signaling remodels the dendritic spine ER to maintain long-term structural plasticity. Proc Natl Acad Sci U S A. 2024 Aug 27; 121(35):e2407324121.
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Sanderson JL, Freund RK, Castano AM, Benke TA, Dell'Acqua ML. The CaV1.2 G406R mutation decreases synaptic inhibition and alters L-type Ca2+ channel-dependent LTP at hippocampal synapses in a mouse model of Timothy Syndrome. Neuropharmacology. 2022 Dec 01; 220:109271.
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Dayal A, Perni S, Franzini-Armstrong C, Beam KG, Grabner M. The distal C terminus of the dihydropyridine receptor ?1a subunit is essential for tetrad formation in skeletal muscle. Proc Natl Acad Sci U S A. 2022 05 10; 119(19):e2201136119.
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Perni S, Beam K. Junctophilins 1, 2, and 3 all support voltage-induced Ca2+ release despite considerable divergence. J Gen Physiol. 2022 09 05; 154(9).
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Beqollari D, Kohrt WM, Bannister RA. Equivalent L-type channel (CaV1.1) function in adult female and male mouse skeletal muscle fibers. Biochem Biophys Res Commun. 2020 02 19; 522(4):996-1002.
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Dittmer PJ, Dell'Acqua ML, Sather WA. Synaptic crosstalk conferred by a zone of differentially regulated Ca2+ signaling in the dendritic shaft adjoining a potentiated spine. Proc Natl Acad Sci U S A. 2019 07 02; 116(27):13611-13620.
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Murphy JG, Crosby KC, Dittmer PJ, Sather WA, Dell'Acqua ML. AKAP79/150 recruits the transcription factor NFAT to regulate signaling to the nucleus by neuronal L-type Ca2+ channels. Mol Biol Cell. 2019 07 01; 30(14):1743-1756.
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