 PTEN Phosphohydrolase
"PTEN Phosphohydrolase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A lipid phosphatase that contains a C2 DOMAIN and acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.
| Descriptor ID |
D051059
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| MeSH Number(s) |
D08.811.277.352.650.850 D12.776.476.590 D12.776.624.776.695
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| Concept/Terms |
PTEN Phosphohydrolase- PTEN Phosphohydrolase
- Phosphohydrolase, PTEN
- PTEN Protein
- Phosphatase and Tensin Homologue on Chromosome Ten Protein
- PTEN Phosphatase
- Phosphatase, PTEN
- MMAC1 Protein
- PTEN Protein Phosphatase
- Phosphatase, PTEN Protein
- Protein Phosphatase, PTEN
- Mutated In Multiple Advanced Cancers 1 Protein
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Below are MeSH descriptors whose meaning is more general than "PTEN Phosphohydrolase".
Below are MeSH descriptors whose meaning is more specific than "PTEN Phosphohydrolase".
This graph shows the total number of publications written about "PTEN Phosphohydrolase" by people in this website by year, and whether "PTEN Phosphohydrolase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 2 | 2 | | 2005 | 0 | 1 | 1 | | 2006 | 1 | 0 | 1 | | 2007 | 0 | 2 | 2 | | 2008 | 3 | 1 | 4 | | 2009 | 0 | 1 | 1 | | 2010 | 2 | 5 | 7 | | 2011 | 4 | 2 | 6 | | 2012 | 0 | 2 | 2 | | 2013 | 5 | 1 | 6 | | 2014 | 3 | 1 | 4 | | 2015 | 3 | 4 | 7 | | 2016 | 2 | 4 | 6 | | 2017 | 2 | 1 | 3 | | 2018 | 4 | 1 | 5 | | 2019 | 3 | 3 | 6 | | 2020 | 1 | 0 | 1 | | 2022 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 | | 2024 | 2 | 2 | 4 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "PTEN Phosphohydrolase" by people in Profiles.
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Schultz KAP, MacFarland SP, Perrino MR, Mitchell SG, Kamihara J, Nelson AT, Mallinger PHR, Brzezinski JJ, Maxwell KN, Woodward ER, Gallinger B, Kim SY, Greer MC, Schneider KW, Scollon SR, Das A, Wasserman JD, Eng C, Malkin D, Foulkes WD, Michaeli O, Bauer AJ, Stewart DR. Update on Pediatric Surveillance Recommendations for PTEN Hamartoma Tumor Syndrome, DICER1-Related Tumor Predisposition, and Tuberous Sclerosis Complex. Clin Cancer Res. 2025 Jan 17; 31(2):234-244.
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Lyu C, Vaddi PK, Elshafae S, Pradeep A, Ma D, Chen S. Unveiling RACK1: a key regulator of the PI3K/AKT pathway in prostate cancer development. Oncogene. 2025 Feb; 44(5):322-335.
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Oatman N, Gawali MV, Congrove S, C?ceres R, Sukumaran A, Gupta N, Murugesan N, Arora P, Subramanian S, Choi K, Abdel-Malek Z, Reisz JA, Stephenson D, Amaravadi R, Desai P, D'Alessandro A, Komurov K, Dasgupta B. A Multimodal Drug-Diet-Immunotherapy Combination Restrains Melanoma Progression and Metastasis. Cancer Res. 2024 Jul 15; 84(14):2333-2351.
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MacFarland SP, Duvall M, Kemajou RT, Baldino SE, Zelley K, Black C, Thomas A, Thomas NH, Ruffner M, Li Y, Miller JS, Brodeur GM, Shabason E. Developmental and behavioral phenotypes of pediatric patients with PTEN hamartoma tumor syndrome. Am J Med Genet A. 2024 08; 194(8):e63608.
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Prasad RR, Mishra N, Kant R, Fox JT, Shoemaker RH, Agarwal C, Raina K, Agarwal R. Effect of nonsteroidal anti-inflammatory drugs (aspirin and naproxen) on inflammation-associated proteomic profiles in mouse plasma and prostate during TMPRSS2-ERG (fusion)-driven prostate carcinogenesis. Mol Carcinog. 2024 Jun; 63(6):1188-1204.
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Shelkowitz E, Stence NV, Neuberger I, Park KL, Saenz MS, Pao E, Oyama N, Friedman SD, Shaw DWW, Mirzaa GM. Variants in PTEN Are Associated With a Diverse Spectrum of Cortical Dysplasia. Pediatr Neurol. 2023 10; 147:154-162.
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Leibowitz MS, Zelley K, Adams D, Brodeur GM, Fox E, Li MM, Mattei P, Pogoriler J, MacFarland SP. Neuroblastoma and cutaneous angiosarcoma in a child with PTEN hamartoma tumor syndrome. Pediatr Blood Cancer. 2022 10; 69(10):e29656.
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Plaks JG, Brewer JA, Jacobsen NK, McKenna M, Uzarski JR, Lawton TJ, Filocamo SF, Kaar JL. Rosetta-Enabled Structural Prediction of Permissive Loop Insertion Sites in Proteins. Biochemistry. 2020 10 20; 59(41):3993-4002.
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Strand KA, Lu S, Mutryn MF, Li L, Zhou Q, Enyart BT, Jolly AJ, Dubner AM, Moulton KS, Nemenoff RA, Koch KA, LaBarbera DV, Weiser-Evans MCM. High Throughput Screen Identifies the DNMT1 (DNA Methyltransferase-1) Inhibitor, 5-Azacytidine, as a Potent Inducer of PTEN (Phosphatase and Tensin Homolog): Central Role for PTEN in 5-Azacytidine Protection Against Pathological Vascular Remodeling. Arterioscler Thromb Vasc Biol. 2020 08; 40(8):1854-1869.
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Lu S, Strand KA, Mutryn MF, Tucker RM, Jolly AJ, Furgeson SB, Moulton KS, Nemenoff RA, Weiser-Evans MCM. PTEN (Phosphatase and Tensin Homolog) Protects Against Ang II (Angiotensin II)-Induced Pathological Vascular Fibrosis and Remodeling-Brief Report. Arterioscler Thromb Vasc Biol. 2020 02; 40(2):394-403.
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