 PTEN Phosphohydrolase
"PTEN Phosphohydrolase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A lipid phosphatase that acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.
| Descriptor ID |
D051059
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| MeSH Number(s) |
D08.811.277.352.650.850 D12.776.476.590 D12.776.624.776.695
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| Concept/Terms |
PTEN Phosphohydrolase- PTEN Phosphohydrolase
- Phosphohydrolase, PTEN
- PTEN Phosphatase
- Phosphatase, PTEN
- Phosphatase and Tensin Homologue on Chromosome Ten Protein
- PTEN Protein
- MMAC1 Protein
- Mutated In Multiple Advanced Cancers 1 Protein
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Below are MeSH descriptors whose meaning is more general than "PTEN Phosphohydrolase".
Below are MeSH descriptors whose meaning is more specific than "PTEN Phosphohydrolase".
This graph shows the total number of publications written about "PTEN Phosphohydrolase" by people in this website by year, and whether "PTEN Phosphohydrolase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 4 | 4 | | 2005 | 0 | 1 | 1 | | 2006 | 4 | 0 | 4 | | 2007 | 1 | 3 | 4 | | 2008 | 5 | 1 | 6 | | 2009 | 1 | 1 | 2 | | 2010 | 3 | 3 | 6 | | 2011 | 4 | 3 | 7 | | 2012 | 1 | 2 | 3 | | 2013 | 6 | 1 | 7 | | 2014 | 4 | 3 | 7 | | 2015 | 4 | 5 | 9 | | 2016 | 2 | 4 | 6 | | 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "PTEN Phosphohydrolase" by people in Profiles.
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Getahun A, Wemlinger SM, Rudra P, Santiago ML, van Dyk LF, Cambier JC. Impaired B cell function during viral infections due to PTEN-mediated inhibition of the PI3K pathway. J Exp Med. 2017 Apr 03; 214(4):931-941.
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Shearn CT, Orlicky DJ, McCullough RL, Jiang H, Maclean KN, Mercer KE, Stiles BL, Saba LM, Ronis MJ, Petersen DR. Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage. PLoS One. 2016; 11(4):e0154152.
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Getahun A, Beavers NA, Larson SR, Shlomchik MJ, Cambier JC. Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells. J Exp Med. 2016 05 02; 213(5):751-69.
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Myers AP, Filiaci VL, Zhang Y, Pearl M, Behbakht K, Makker V, Hanjani P, Zweizig S, Burke JJ, Downey G, Leslie KK, Van Hummelen P, Birrer MJ, Fleming GF. Tumor mutational analysis of GOG248, a phase II study of temsirolimus or temsirolimus and alternating megestrol acetate and tamoxifen for advanced endometrial cancer (EC): An NRG Oncology/Gynecologic Oncology Group study. Gynecol Oncol. 2016 Apr; 141(1):43-8.
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Du Z, Sun T, Hacisuleyman E, Fei T, Wang X, Brown M, Rinn JL, Lee MG, Chen Y, Kantoff PW, Liu XS. Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer. Nat Commun. 2016 Mar 15; 7:10982.
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Horita H, Wysoczynski CL, Walker LA, Moulton KS, Li M, Ostriker A, Tucker R, McKinsey TA, Churchill ME, Nemenoff RA, Weiser-Evans MC. Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation. Nat Commun. 2016 Mar 04; 7:10830.
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Shows J, Marshall C, Perry A, Kleinschmidt-DeMasters BK. Genetics of Glioblastomas in Rare Anatomical Locations: Spinal Cord and Optic Nerve. Brain Pathol. 2016 Jan; 26(1):120-3.
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Richmond CA, Shah MS, Deary LT, Trotier DC, Thomas H, Ambruzs DM, Jiang L, Whiles BB, Rickner HD, Montgomery RK, Tovaglieri A, Carlone DL, Breault DT. Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status. Cell Rep. 2015 Dec 22; 13(11):2403-2411.
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Chen Z, Getahun A, Chen X, Dollin Y, Cambier JC, Wang JH. Imbalanced PTEN and PI3K Signaling Impairs Class Switch Recombination. J Immunol. 2015 Dec 01; 195(11):5461-5471.
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Corcoran RB, Atreya CE, Falchook GS, Kwak EL, Ryan DP, Bendell JC, Hamid O, Messersmith WA, Daud A, Kurzrock R, Pierobon M, Sun P, Cunningham E, Little S, Orford K, Motwani M, Bai Y, Patel K, Venook AP, Kopetz S. Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600-Mutant Colorectal Cancer. J Clin Oncol. 2015 Dec 01; 33(34):4023-31.
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