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Christopher D Link

TitleAssociate Professor
InstitutionUniversity of Colorado Boulder
DepartmentIntegrative Physiology
Phone303/735-5112

    Collapse Research 
    Collapse research activities and funding
    R21AG067147     (JOHNSON, THOMAS E.)Sep 15, 2020 - Apr 30, 2022
    NIH
    C. Elegans as a Model of Cell Senescence and Alzheimer's Disease
    Role: Co-Principal Investigator
    R01AG064465     (OPP, MARK R)Aug 1, 2019 - Apr 30, 2024
    NIH/NIA
    Sleep Disruption and Alzheimer's Disease Pathology
    Role: Co-Principal Investigator
    RF1AG064465     (OPP, MARK R)Aug 1, 2019 - Mar 31, 2024
    NIH
    Sleep Disruption and Alzheimer's Disease Pathology
    Role: Co-Principal Investigator
    R21AG049693     (LINK, CHRISTOPHER D.)Sep 1, 2015 - Apr 30, 2018
    NIH
    Abeta Oligomers and Mechanisms of Neuronal Cell Death in Alzheimer's Disease
    Role: Principal Investigator
    R01NS063964     (LINK, CHRISTOPHER D.)Apr 1, 2009 - Oct 31, 2020
    NIH
    TDP-43, RNA Metabolism, and ALS/FTD Pathology
    Role: Principal Investigator
    R01AG021037     (LINK, CHRISTOPHER D.)Jun 1, 2003 - May 31, 2008
    NIH
    Comparative Modeling of Neurodegenerative Diseases
    Role: Principal Investigator
    R01AG012423     (LINK, CHRISTOPHER D.)Sep 1, 1996 - Mar 31, 2013
    NIH
    Transgenic C. elegans as Amyloid Disease Model
    Role: Principal Investigator
    R29HD026087     (LINK, CHRISTOPHER D)Jul 1, 1989 - Jun 30, 1995
    NIH
    GENETIC ANALYSIS OF BURSAL MORPHOGENESIS IN C ELEGANS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Milstead RA, Link CD, Xu Z, Hoeffer CA. TDP-43 knockdown in mouse model of ALS leads to dsRNA deposition, gliosis, and neurodegeneration in the spinal cord. Cereb Cortex. 2023 05 09; 33(10):5808-5816. PMID: 36443249.
      View in: PubMed
    2. Wahl D, Smith ME, McEntee CM, Cavalier AN, Osburn SC, Burke SD, Grant RA, Nerguizian D, Lark DS, Link CD, LaRocca TJ. The reverse transcriptase inhibitor 3TC protects against age-related cognitive dysfunction. Aging Cell. 2023 05; 22(5):e13798. PMID: 36949552.
      View in: PubMed
    3. Sharma S, Borski C, Hanson J, Garcia MA, Link CD, Hoeffer C, Chatterjee A, Nagpal P. Identifying an Optimal Neuroinflammation Treatment Using a Nanoligomer Discovery Engine. ACS Chem Neurosci. 2022 Dec 07; 13(23):3247-3256. PMID: 36410860.
      View in: PubMed
    4. Henderson YO, Bithi N, Yang J, Link C, Zhang A, Baron B, Maina E, Hine C. A long-term obesogenic high-fat diet in mice partially dampens the anti-frailty benefits of late-life intermittent fasting. Geroscience. 2023 04; 45(2):1247-1262. PMID: 36287320.
      View in: PubMed
    5. Melnick M, Gonzales P, LaRocca TJ, Song Y, Wuu J, Benatar M, Oskarsson B, Petrucelli L, Dowell RD, Link CD, Prudencio M. Application of a bioinformatic pipeline to RNA-seq data identifies novel virus-like sequence in human blood. G3 (Bethesda). 2021 09 06; 11(9). PMID: 33914880.
      View in: PubMed
    6. LaRocca TJ, Cavalier AN, Roberts CM, Lemieux MR, Ramesh P, Garcia MA, Link CD. Amyloid beta acts synergistically as a pro-inflammatory cytokine. Neurobiol Dis. 2021 11; 159:105493. PMID: 34464705.
      View in: PubMed
    7. Link CD. Is There a Brain Microbiome? Neurosci Insights. 2021; 16:26331055211018709. PMID: 34104888.
      View in: PubMed
    8. Jonsson WO, Margolies NS, Mirek ET, Zhang Q, Linden MA, Hill CM, Link C, Bithi N, Zalma B, Levy JL, Pettit AP, Miller JW, Hine C, Morrison CD, Gettys TW, Miller BF, Hamilton KL, Wek RC, Anthony TG. Physiologic Responses to Dietary Sulfur Amino Acid Restriction in Mice Are Influenced by Atf4 Status and Biological Sex. J Nutr. 2021 04 08; 151(4):785-799. PMID: 33512502.
      View in: PubMed
    9. Bithi N, Link C, Henderson YO, Kim S, Yang J, Li L, Wang R, Willard B, Hine C. Dietary restriction transforms the mammalian protein persulfidome in a tissue-specific and cystathionine ?-lyase-dependent manner. Nat Commun. 2021 03 19; 12(1):1745. PMID: 33741971.
      View in: PubMed
    10. Henderson YO, Bithi N, Link C, Yang J, Schugar R, Llarena N, Brown JM, Hine C. Late-life intermittent fasting decreases aging-related frailty and increases renal hydrogen sulfide production in a sexually dimorphic manner. Geroscience. 2021 08; 43(4):1527-1554. PMID: 33675469.
      View in: PubMed
    11. Brunt VE, LaRocca TJ, Bazzoni AE, Sapinsley ZJ, Miyamoto-Ditmon J, Gioscia-Ryan RA, Neilson AP, Link CD, Seals DR. The gut microbiome-derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging. Geroscience. 2021 02; 43(1):377-394. PMID: 32862276.
      View in: PubMed
    12. LaRocca TJ, Mariani A, Watkins LR, Link CD. TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes. Neurobiol Dis. 2019 12; 132:104514. PMID: 31229690.
      View in: PubMed
    13. Shea D, Hsu CC, Bi TM, Paranjapye N, Childers MC, Cochran J, Tomberlin CP, Wang L, Paris D, Zonderman J, Varani G, Link CD, Mullan M, Daggett V. a-Sheet secondary structure in amyloid ?-peptide drives aggregation and toxicity in Alzheimer's disease. Proc Natl Acad Sci U S A. 2019 04 30; 116(18):8895-8900. PMID: 31004062.
      View in: PubMed
    14. Melnick M, Gonzales P, Cabral J, Allen MA, Dowell RD, Link CD. Heat shock in C. elegans induces downstream of gene transcription and accumulation of double-stranded RNA. PLoS One. 2019; 14(4):e0206715. PMID: 30958820.
      View in: PubMed
    15. Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, Lin WL, Tong J, Daughrity LM, Yue M, Song Y, Andersen JW, Castanedes-Casey M, Kurti A, Datta A, Antognetti G, McCampbell A, Rademakers R, Oskarsson B, Dickson DW, Kampmann M, Ward ME, Fryer JD, Link CD, Shorter J, Petrucelli L. Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity. Science. 2019 02 15; 363(6428). PMID: 30765536.
      View in: PubMed
    16. Guerrero-G?mez D, Mora-Lorca JA, S?enz-Narciso B, Naranjo-Galindo FJ, Mu?oz-Lobato F, Parrado-Fern?ndez C, Goikolea J, Cedazo-Minguez ?, Link CD, Neri C, Sequedo MD, V?zquez-Manrique RP, Fern?ndez-Su?rez E, Goder V, Pan? R, Cabiscol E, Askjaer P, Cabello J, Miranda-Vizuete A. Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation. Cell Death Differ. 2019 09; 26(9):1545-1565. PMID: 30770874.
      View in: PubMed
    17. Saldi TK, Gonzales PK, LaRocca TJ, Link CD. Neurodegeneration, Heterochromatin, and Double-Stranded RNA. J Exp Neurosci. 2019; 13:1179069519830697. PMID: 30792577.
      View in: PubMed
    18. Julien C, Tomberlin C, Roberts CM, Akram A, Stein GH, Silverman MA, Link CD. In vivo induction of membrane damage by ?-amyloid peptide oligomers. Acta Neuropathol Commun. 2018 11 29; 6(1):131. PMID: 30497524.
      View in: PubMed
    19. Saldi TK, Gonzales P, Garrido-Lecca A, Dostal V, Roberts CM, Petrucelli L, Link CD. The Caenorhabditis elegans Ortholog of TDP-43 Regulates the Chromatin Localization of the Heterochromatin Protein 1 Homolog HPL-2. Mol Cell Biol. 2018 08 01; 38(15). PMID: 29760282.
      View in: PubMed
    20. Gonzales PK, Roberts CM, Fonte V, Jacobsen C, Stein GH, Link CD. Transcriptome analysis of genetically matched human induced pluripotent stem cells disomic or trisomic for chromosome 21. PLoS One. 2018; 13(3):e0194581. PMID: 29584757.
      View in: PubMed
    21. Van Treeck B, Protter DSW, Matheny T, Khong A, Link CD, Parker R. RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome. Proc Natl Acad Sci U S A. 2018 03 13; 115(11):2734-2739. PMID: 29483269.
      View in: PubMed
    22. Prudencio M, Gonzales PK, Cook CN, Gendron TF, Daughrity LM, Song Y, Ebbert MTW, van Blitterswijk M, Zhang YJ, Jansen-West K, Baker MC, DeTure M, Rademakers R, Boylan KB, Dickson DW, Petrucelli L, Link CD. Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients. Hum Mol Genet. 2017 09 01; 26(17):3421-3431. PMID: 28637276.
      View in: PubMed
    23. Kim SA, D'Acunto VF, Kokona B, Hofmann J, Cunningham NR, Bistline EM, Garcia FJ, Akhtar NM, Hoffman SH, Doshi SH, Ulrich KM, Jones NM, Bonini NM, Roberts CM, Link CD, Laue TM, Fairman R. Sedimentation Velocity Analysis with Fluorescence Detection of Mutant Huntingtin Exon 1 Aggregation in Drosophila melanogaster and Caenorhabditis elegans. Biochemistry. 2017 09 05; 56(35):4676-4688. PMID: 28786671.
      View in: PubMed
    24. Henze A, Homann T, Rohn I, Aschner M, Link CD, Kleuser B, Schweigert FJ, Schwerdtle T, Bornhorst J. Caenorhabditis elegans as a model system to study post-translational modifications of human transthyretin. Sci Rep. 2016 11 21; 6:37346. PMID: 27869126.
      View in: PubMed
    25. Kramer NJ, Carlomagno Y, Zhang YJ, Almeida S, Cook CN, Gendron TF, Prudencio M, Van Blitterswijk M, Belzil V, Couthouis J, Paul JW, Goodman LD, Daughrity L, Chew J, Garrett A, Pregent L, Jansen-West K, Tabassian LJ, Rademakers R, Boylan K, Graff-Radford NR, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Boeve BF, Deng N, Feng Y, Cheng TH, Dickson DW, Cohen SN, Bonini NM, Link CD, Gao FB, Petrucelli L, Gitler AD. Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts. Science. 2016 Aug 12; 353(6300):708-12. PMID: 27516603.
      View in: PubMed
    26. Munk?csy E, Khan MH, Lane RK, Borror MB, Park JH, Bokov AF, Fisher AL, Link CD, Rea SL. DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans. PLoS Genet. 2016 07; 12(7):e1006133. PMID: 27420916.
      View in: PubMed
    27. Zhang YJ, Gendron TF, Grima JC, Sasaguri H, Jansen-West K, Xu YF, Katzman RB, Gass J, Murray ME, Shinohara M, Lin WL, Garrett A, Stankowski JN, Daughrity L, Tong J, Perkerson EA, Yue M, Chew J, Castanedes-Casey M, Kurti A, Wang ZS, Liesinger AM, Baker JD, Jiang J, Lagier-Tourenne C, Edbauer D, Cleveland DW, Rademakers R, Boylan KB, Bu G, Link CD, Dickey CA, Rothstein JD, Dickson DW, Fryer JD, Petrucelli L. C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins. Nat Neurosci. 2016 05; 19(5):668-677. PMID: 26998601.
      View in: PubMed
    28. Kokona B, May CA, Cunningham NR, Richmond L, Jay Garcia F, Durante JC, Ulrich KM, Roberts CM, Link CD, Stafford WF, Laue TM, Fairman R. Studying polyglutamine aggregation in Caenorhabditis elegans using an analytical ultracentrifuge equipped with fluorescence detection. Protein Sci. 2016 Mar; 25(3):605-17. PMID: 26647351.
      View in: PubMed
    29. Prudencio M, Belzil VV, Batra R, Ross CA, Gendron TF, Pregent LJ, Murray ME, Overstreet KK, Piazza-Johnston AE, Desaro P, Bieniek KF, DeTure M, Lee WC, Biendarra SM, Davis MD, Baker MC, Perkerson RB, van Blitterswijk M, Stetler CT, Rademakers R, Link CD, Dickson DW, Boylan KB, Li H, Petrucelli L. Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS. Nat Neurosci. 2015 Aug; 18(8):1175-82. PMID: 26192745.
      View in: PubMed
    30. Saldi TK, Ash PE, Wilson G, Gonzales P, Garrido-Lecca A, Roberts CM, Dostal V, Gendron TF, Stein LD, Blumenthal T, Petrucelli L, Link CD. TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA. EMBO J. 2014 Dec 17; 33(24):2947-66. PMID: 25391662.
      View in: PubMed
    31. Hassan WM, Dostal V, Huemann BN, Yerg JE, Link CD. Identifying A?-specific pathogenic mechanisms using a nematode model of Alzheimer's disease. Neurobiol Aging. 2015 Feb; 36(2):857-66. PMID: 25457027.
      View in: PubMed
    32. Machino K, Link CD, Wang S, Murakami H, Murakami S. A semi-automated motion-tracking analysis of locomotion speed in the C. elegans transgenics overexpressing beta-amyloid in neurons. Front Genet. 2014; 5:202. PMID: 25071831.
      View in: PubMed
    33. McColl G, Roberts BR, Pukala TL, Kenche VB, Roberts CM, Link CD, Ryan TM, Masters CL, Barnham KJ, Bush AI, Cherny RA. Utility of an improved model of amyloid-beta (A?1?42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease. Mol Neurodegener. 2012 Nov 21; 7:57. PMID: 23171715.
      View in: PubMed
    34. Gass J, Lee WC, Cook C, Finch N, Stetler C, Jansen-West K, Lewis J, Link CD, Rademakers R, Nykj?r A, Petrucelli L. Progranulin regulates neuronal outgrowth independent of sortilin. Mol Neurodegener. 2012 Jul 10; 7:33. PMID: 22781549.
      View in: PubMed
    35. Cotella D, Hernandez-Enriquez B, Wu X, Li R, Pan Z, Leveille J, Link CD, Oddo S, Sesti F. Toxic role of K+ channel oxidation in mammalian brain. J Neurosci. 2012 Mar 21; 32(12):4133-44. PMID: 22442077.
      View in: PubMed
    36. Link CD, Saldi TK. Development. Cell death by glutamine repeats? Science. 2012 Feb 24; 335(6071):926-7. PMID: 22362996.
      View in: PubMed
    37. Fonte V, Dostal V, Roberts CM, Gonzales P, Lacor PN, Lacor P, Velasco PT, Magrane J, Dingwell N, Fan EY, Silverman MA, Stein GH, Link CD. A glycine zipper motif mediates the formation of toxic ?-amyloid oligomers in vitro and in vivo. Mol Neurodegener. 2011 Aug 23; 6(1):61. PMID: 21861874.
      View in: PubMed
    38. Mendenhall AR, Wu D, Park SK, Cypser JR, Tedesco PM, Link CD, Phillips PC, Johnson TE. Genetic dissection of late-life fertility in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci. 2011 Aug; 66(8):842-54. PMID: 21622982.
      View in: PubMed
    39. Dostal V, Link CD. Assaying ?-amyloid toxicity using a transgenic C. elegans model. J Vis Exp. 2010 Oct 09; (44). PMID: 20972410.
      View in: PubMed
    40. McColl G, Rogers AN, Alavez S, Hubbard AE, Melov S, Link CD, Bush AI, Kapahi P, Lithgow GJ. Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans. Cell Metab. 2010 Sep 08; 12(3):260-72. PMID: 20816092.
      View in: PubMed
    41. Dostal V, Roberts CM, Link CD. Genetic mechanisms of coffee extract protection in a Caenorhabditis elegans model of ?-amyloid peptide toxicity. Genetics. 2010 Nov; 186(3):857-66. PMID: 20805557.
      View in: PubMed
    42. Ash PE, Zhang YJ, Roberts CM, Saldi T, Hutter H, Buratti E, Petrucelli L, Link CD. Neurotoxic effects of TDP-43 overexpression in C. elegans. Hum Mol Genet. 2010 Aug 15; 19(16):3206-18. PMID: 20530643.
      View in: PubMed
    43. Dosanjh LE, Brown MK, Rao G, Link CD, Luo Y. Behavioral phenotyping of a transgenic Caenorhabditis elegans expressing neuronal amyloid-beta. J Alzheimers Dis. 2010; 19(2):681-90. PMID: 20110612.
      View in: PubMed
    44. Teschendorf D, Link CD. What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases? Mol Neurodegener. 2009 Sep 28; 4:38. PMID: 19785750.
      View in: PubMed
    45. Park SK, Link CD, Johnson TE. Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans. FASEB J. 2010 Feb; 24(2):383-92. PMID: 19783783.
      View in: PubMed
    46. Hassan WM, Merin DA, Fonte V, Link CD. AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model. Hum Mol Genet. 2009 Aug 01; 18(15):2739-47. PMID: 19414486.
      View in: PubMed
    47. Zhang YJ, Xu YF, Cook C, Gendron TF, Roettges P, Link CD, Lin WL, Tong J, Castanedes-Casey M, Ash P, Gass J, Rangachari V, Buratti E, Baralle F, Golde TE, Dickson DW, Petrucelli L. Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7607-12. PMID: 19383787.
      View in: PubMed
    48. Link CD, Fonte V, Roberts CM, Hiester B, Silverman MA, Stein GH. The beta amyloid peptide can act as a modular aggregation domain. Neurobiol Dis. 2008 Dec; 32(3):420-5. PMID: 18778773.
      View in: PubMed
    49. Fonte V, Kipp DR, Yerg J, Merin D, Forrestal M, Wagner E, Roberts CM, Link CD. Suppression of in vivo beta-amyloid peptide toxicity by overexpression of the HSP-16.2 small chaperone protein. J Biol Chem. 2008 Jan 11; 283(2):784-91. PMID: 17993648.
      View in: PubMed
    50. Florez-McClure ML, Hohsfield LA, Fonte G, Bealor MT, Link CD. Decreased insulin-receptor signaling promotes the autophagic degradation of beta-amyloid peptide in C. elegans. Autophagy. 2007 Nov-Dec; 3(6):569-80. PMID: 17675890.
      View in: PubMed
    51. Stas S, Whaley-Connell A, Habibi J, Appesh L, Hayden MR, Karuparthi PR, Qazi M, Morris EM, Cooper SA, Link CD, Stump C, Hay M, Ferrario C, Sowers JR. Mineralocorticoid receptor blockade attenuates chronic overexpression of the renin-angiotensin-aldosterone system stimulation of reduced nicotinamide adenine dinucleotide phosphate oxidase and cardiac remodeling. Endocrinology. 2007 Aug; 148(8):3773-80. PMID: 17494996.
      View in: PubMed
    52. Wu Y, Wu Z, Butko P, Christen Y, Lambert MP, Klein WL, Link CD, Luo Y. Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans. J Neurosci. 2006 Dec 13; 26(50):13102-13. PMID: 17167099.
      View in: PubMed
    53. Link CD. C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease. Exp Gerontol. 2006 Oct; 41(10):1007-13. PMID: 16930903.
      View in: PubMed
    54. Whaley-Connell AT, Chowdhury NA, Hayden MR, Stump CS, Habibi J, Wiedmeyer CE, Gallagher PE, Tallant EA, Cooper SA, Link CD, Ferrario C, Sowers JR. Oxidative stress and glomerular filtration barrier injury: role of the renin-angiotensin system in the Ren2 transgenic rat. Am J Physiol Renal Physiol. 2006 Dec; 291(6):F1308-14. PMID: 16788142.
      View in: PubMed
    55. Link CD, Fonte V, Hiester B, Yerg J, Ferguson J, Csontos S, Silverman MA, Stein GH. Conversion of green fluorescent protein into a toxic, aggregation-prone protein by C-terminal addition of a short peptide. J Biol Chem. 2006 Jan 20; 281(3):1808-16. PMID: 16239215.
      View in: PubMed
    56. Gutierrez-Zepeda A, Santell R, Wu Z, Brown M, Wu Y, Khan I, Link CD, Zhao B, Luo Y. Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans. BMC Neurosci. 2005 Aug 25; 6:54. PMID: 16122394.
      View in: PubMed
    57. Boyd-Kimball D, Poon HF, Lynn BC, Cai J, Pierce WM, Klein JB, Ferguson J, Link CD, Butterfield DA. Proteomic identification of proteins specifically oxidized in Caenorhabditis elegans expressing human Abeta(1-42): implications for Alzheimer's disease. Neurobiol Aging. 2006 Sep; 27(9):1239-49. PMID: 16099075.
      View in: PubMed
    58. Cottrell BA, Galvan V, Banwait S, Gorostiza O, Lombardo CR, Williams T, Schilling B, Peel A, Gibson B, Koo EH, Link CD, Bredesen DE. A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease. Ann Neurol. 2005 Aug; 58(2):277-89. PMID: 16049941.
      View in: PubMed
    59. Kapulkin WJ, Kapulkin V, Hiester BG, Link CD. Compensatory regulation among ER chaperones in C. elegans. FEBS Lett. 2005 Jun 06; 579(14):3063-8. PMID: 15907843.
      View in: PubMed
    60. Link CD. Invertebrate models of Alzheimer's disease. Genes Brain Behav. 2005 Apr; 4(3):147-56. PMID: 15810903.
      View in: PubMed
    61. Strayer A, Wu Z, Christen Y, Link CD, Luo Y. Expression of the small heat-shock protein Hsp16-2 in Caenorhabditis elegans is suppressed by Ginkgo biloba extract EGb 761. FASEB J. 2003 Dec; 17(15):2305-7. PMID: 14525938.
      View in: PubMed
    62. Leiers B, Kampk?tter A, Grevelding CG, Link CD, Johnson TE, Henkle-D?hrsen K. A stress-responsive glutathione S-transferase confers resistance to oxidative stress in Caenorhabditis elegans. Free Radic Biol Med. 2003 Jun 01; 34(11):1405-15. PMID: 12757851.
      View in: PubMed
    63. Link CD, Taft A, Kapulkin V, Duke K, Kim S, Fei Q, Wood DE, Sahagan BG. Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model. Neurobiol Aging. 2003 May-Jun; 24(3):397-413. PMID: 12600716.
      View in: PubMed
    64. Drake J, Link CD, Butterfield DA. Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide (1-42) in a transgenic Caenorhabditis elegans model. Neurobiol Aging. 2003 May-Jun; 24(3):415-20. PMID: 12600717.
      View in: PubMed
    65. Kampk?tter A, Volkmann TE, de Castro SH, Leiers B, Klotz LO, Johnson TE, Link CD, Henkle-D?hrsen K. Functional analysis of the glutathione S-transferase 3 from Onchocerca volvulus (Ov-GST-3): a parasite GST confers increased resistance to oxidative stress in Caenorhabditis elegans. J Mol Biol. 2003 Jan 03; 325(1):25-37. PMID: 12473450.
      View in: PubMed
    66. Fonte V, Kapulkin WJ, Kapulkin V, Taft A, Fluet A, Friedman D, Link CD. Interaction of intracellular beta amyloid peptide with chaperone proteins. Proc Natl Acad Sci U S A. 2002 Jul 09; 99(14):9439-44. PMID: 12089340.
      View in: PubMed
    67. Blumenthal T, Evans D, Link CD, Guffanti A, Lawson D, Thierry-Mieg J, Thierry-Mieg D, Chiu WL, Duke K, Kiraly M, Kim SK. A global analysis of Caenorhabditis elegans operons. Nature. 2002 Jun 20; 417(6891):851-4. PMID: 12075352.
      View in: PubMed
    68. GuhaThakurta D, Palomar L, Stormo GD, Tedesco P, Johnson TE, Walker DW, Lithgow G, Kim S, Link CD. Identification of a novel cis-regulatory element involved in the heat shock response in Caenorhabditis elegans using microarray gene expression and computational methods. Genome Res. 2002 May; 12(5):701-12. PMID: 11997337.
      View in: PubMed
    69. Johnson TE, Henderson S, Murakami S, de Castro E, de Castro SH, Cypser J, Rikke B, Tedesco P, Link C. Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease. J Inherit Metab Dis. 2002 May; 25(3):197-206. PMID: 12137228.
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    70. Link CD, Johnson CJ. Reporter transgenes for study of oxidant stress in Caenorhabditis elegans. Methods Enzymol. 2002; 353:497-505. PMID: 12078522.
      View in: PubMed
    71. Link CD, Johnson CJ, Fonte V, Paupard M, Hall DH, Styren S, Mathis CA, Klunk WE. Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34. Neurobiol Aging. 2001 Mar-Apr; 22(2):217-26. PMID: 11182471.
      View in: PubMed
    72. Johnson TE, Cypser J, de Castro E, de Castro S, Henderson S, Murakami S, Rikke B, Tedesco P, Link C. Gerontogenes mediate health and longevity in nematodes through increasing resistance to environmental toxins and stressors. Exp Gerontol. 2000 Sep; 35(6-7):687-94. PMID: 11053658.
      View in: PubMed
    73. Link CD, Cypser JR, Johnson CJ, Johnson TE. Direct observation of stress response in Caenorhabditis elegans using a reporter transgene. Cell Stress Chaperones. 1999 Dec; 4(4):235-42. PMID: 10590837.
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    74. Fay DS, Fluet A, Johnson CJ, Link CD. In vivo aggregation of beta-amyloid peptide variants. J Neurochem. 1998 Oct; 71(4):1616-25. PMID: 9751195.
      View in: PubMed
    75. Link CD, Ehrenfels CW, Wood WB. Mutant expression of male copulatory bursa surface markers in Caenorhabditis elegans. Development. 1988 Jul; 103(3):485-95. PMID: 3246219.
      View in: PubMed
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