 Complement Factor B
"Complement Factor B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A glycine-rich, heat-labile serum glycoprotein that contains a component of the C3 CONVERTASE ALTERNATE PATHWAY (C3bBb). Bb, a serine protease, is generated when factor B is cleaved by COMPLEMENT FACTOR D into Ba and Bb.
| Descriptor ID |
D011415
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| MeSH Number(s) |
D08.622.200 D08.811.277.656.300.760.198 D08.811.277.656.959.350.198 D12.776.124.486.274.900
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| Concept/Terms |
Complement Factor B- Complement Factor B
- Factor B, Complement
- C3 Proactivator
- Proactivator, C3
- C3PA
- Complement 3 Proactivator
- Proactivator, Complement 3
- Factor B
- Complement Protein B
- Protein B, Complement
- Complement Protein Factor B
- Properdin Factor B
- Factor B, Properdin
- Complement Factor B, Alternative Pathway
Complement Factor Bb- Complement Factor Bb
- Bb, Complement Factor
- Factor Bb, Complement
- Properdin Factor Bb
- Factor Bb, Properdin
- Complement Factor B-Derived Fragment Bb
- Complement Factor B Derived Fragment Bb
- Bb Fragment of Factor B
- Complement Factor B Fragment, Bb
Complement Factor Ba- Complement Factor Ba
- Factor Ba, Complement
- Properdin Factor Ba
- Factor Ba, Properdin
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Below are MeSH descriptors whose meaning is more general than "Complement Factor B".
Below are MeSH descriptors whose meaning is more specific than "Complement Factor B".
This graph shows the total number of publications written about "Complement Factor B" by people in this website by year, and whether "Complement Factor B" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 1 | 2 | | 2000 | 1 | 1 | 2 | | 2003 | 1 | 0 | 1 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 2 | 1 | 3 | | 2007 | 2 | 0 | 2 | | 2008 | 2 | 1 | 3 | | 2009 | 1 | 3 | 4 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 2 | 1 | 3 | | 2013 | 2 | 1 | 3 | | 2014 | 0 | 1 | 1 | | 2015 | 2 | 0 | 2 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2019 | 3 | 2 | 5 | | 2020 | 0 | 3 | 3 | | 2021 | 1 | 0 | 1 | | 2022 | 1 | 0 | 1 | | 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Complement Factor B" by people in Profiles.
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Stenson EK, Edelstein CL, You Z, Miyazaki-Anzai S, Thurman JM, Dixon BP, Zappitelli M, Goldstein SL, Akcan Arikan A, Kendrick J. Urine Complement Factor Ba Is Associated with AKI in Critically Ill Children. Kidney360. 2023 03 01; 4(3):326-332.
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Marin AI, Poppelaars F, Wagner BD, Palestine AG, Patnaik JL, Holers VM, Frazer-Abel AA, Mathias MT, Manoharan N, Fonteh CN, Mandava N, Lynch AM. Sex and Age-Related Differences in Complement Factors Among Patients With Intermediate Age-Related Macular Degeneration. Transl Vis Sci Technol. 2022 05 02; 11(5):22.
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Takahashi K, Banda NK, Holers VM, Van Cott EM. Complement component factor B has thrombin-like activity. Biochem Biophys Res Commun. 2021 05 07; 552:17-22.
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Fan X, McCullough RL, Huang E, Bellar A, Kim A, Poulsen KL, McClain CJ, Mitchell M, McCullough AJ, Radaeva S, Barton B, Szabo G, Dasarathy S, Rotroff DM, Nagy LE. Diagnostic and Prognostic Significance of Complement in Patients With Alcohol-Associated Hepatitis. Hepatology. 2021 03; 73(3):983-997.
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Chen JY, Galwankar NS, Emch HN, Menon SS, Cortes C, Thurman JM, Merrill SA, Brodsky RA, Ferreira VP. Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation. Front Immunol. 2020; 11:1460.
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Frid MG, McKeon BA, Thurman JM, Maron BA, Li M, Zhang H, Kumar S, Sullivan T, Laskowsky J, Fini MA, Hu S, Tuder RM, Gandjeva A, Wilkins MR, Rhodes CJ, Ghataorhe P, Leopold JA, Wang RS, Holers VM, Stenmark KR. Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension. Am J Respir Crit Care Med. 2020 01 15; 201(2):224-239.
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Jager NM, van Zanden JE, Sub?as M, Leuvenink HGD, Daha MR, Rodr?guez de C?rdoba S, Poppelaars F, Seelen MA. Blocking Complement Factor B Activation Reduces Renal Injury and Inflammation in a Rat Brain Death Model. Front Immunol. 2019; 10:2528.
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Chisholm CF, Behnke W, Pokhilchuk Y, Frazer-Abel AA, Randolph TW. Subvisible Particles in IVIg Formulations Activate Complement in Human Serum. J Pharm Sci. 2020 01; 109(1):558-565.
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Laskowski J, Philbrook HT, Parikh CR, Thurman JM. Urine complement activation fragments are increased in patients with kidney injury after cardiac surgery. Am J Physiol Renal Physiol. 2019 09 01; 317(3):F650-F657.
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Lynch AM, Mandava N, Patnaik JL, Frazer-Abel AA, Wagner BD, Palestine AG, Mathias MT, Siringo FS, Cathcart JN, Holers VM. Systemic activation of the complement system in patients with advanced age-related macular degeneration. Eur J Ophthalmol. 2020 Sep; 30(5):1061-1068.
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