 Fibrinolysin
"Fibrinolysin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A product of the lysis of plasminogen (profibrinolysin) by PLASMINOGEN activators. It is composed of two polypeptide chains, light (B) and heavy (A), with a molecular weight of 75,000. It is the major proteolytic enzyme involved in blood clot retraction or the lysis of fibrin and quickly inactivated by antiplasmins.
| Descriptor ID |
D005341
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| MeSH Number(s) |
D08.811.277.656.300.760.330 D08.811.277.656.959.350.330
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| Concept/Terms |
Fibrinolysin- Fibrinolysin
- Plasmin
- Protease F
- Glu-Plasmin
- Glu Plasmin
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Below are MeSH descriptors whose meaning is more general than "Fibrinolysin".
Below are MeSH descriptors whose meaning is more specific than "Fibrinolysin".
This graph shows the total number of publications written about "Fibrinolysin" by people in this website by year, and whether "Fibrinolysin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 0 | 1 | | 2009 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2015 | 1 | 1 | 2 | | 2019 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 | | 2022 | 1 | 0 | 1 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Fibrinolysin" by people in Profiles.
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Coleman JR, Moore EE, Kelher MR, Jones K, Cohen MJ, Banerjee A, Silliman CC. Elucidating the molecular mechanisms of fibrinolytic shutdown after severe injury: The role of thrombin-activatable fibrinolysis inhibitor. J Trauma Acute Care Surg. 2023 06 01; 94(6):857-862.
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Lawson MA, Holle LA, Dow NE, Hennig G, de Laat B, Moore HB, Moore EE, Cohen MJ, Bouchard BA, Freeman K, Wolberg AS. Plasma-based assays distinguish hyperfibrinolysis and shutdown subgroups in trauma-induced coagulopathy. J Trauma Acute Care Surg. 2022 11 01; 93(5):579-587.
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Morton AP, Hadley JB, Ghasabyan A, Kelher MR, Moore EE, Bevers S, Dzieciatkowska M, Hansen KC, Cohen MS, Banerjee A, Silliman CC. The a-globin chain of hemoglobin potentiates tissue plasminogen activator induced hyperfibrinolysis in vitro. J Trauma Acute Care Surg. 2022 01 01; 92(1):159-166.
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Barrett CD, Moore HB, Vigneshwar N, Dhara S, Chandler J, Chapman MP, Sauaia A, Moore EE, Yaffe MB. Plasmin thrombelastography rapidly identifies trauma patients at risk for massive transfusion, mortality, and hyperfibrinolysis: A diagnostic tool to resolve an international debate on tranexamic acid? J Trauma Acute Care Surg. 2020 12; 89(6):991-998.
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Wu TB, Orfeo T, Moore HB, Sumislawski JJ, Cohen MJ, Petzold LR. Computational model of tranexamic acid on urokinase mediated fibrinolysis. PLoS One. 2020; 15(5):e0233640.
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Miszta A, Kopec AK, Pant A, Holle LA, Byrnes JR, Lawrence DA, Hansen KC, Flick MJ, Luyendyk JP, de Laat B, Wolberg AS. A high-fat diet delays plasmin generation in a thrombomodulin-dependent manner in mice. Blood. 2020 05 07; 135(19):1704-1717.
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Disharoon D, Marr DWM, Neeves KB. Engineered microparticles and nanoparticles for fibrinolysis. J Thromb Haemost. 2019 12; 17(12):2004-2015.
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Moore HB, Moore BA, Sauaia A, Moore EE. Clinical relevance and practical assessment of fibrinolysis shutdown. ANZ J Surg. 2020 04; 90(4):413-414.
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Barrett CD, Moore HB, Kong YW, Chapman MP, Sriram G, Lim D, Moore EE, Yaffe MB. Tranexamic acid mediates proinflammatory and anti-inflammatory signaling via complement C5a regulation in a plasminogen activator-dependent manner. J Trauma Acute Care Surg. 2019 01; 86(1):101-107.
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Moore EE, Moore HB, Gonzalez E, Chapman MP, Hansen KC, Sauaia A, Silliman CC, Banerjee A. Postinjury fibrinolysis shutdown: Rationale for selective tranexamic acid. J Trauma Acute Care Surg. 2015 Jun; 78(6 Suppl 1):S65-9.
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