 Factor IX
"Factor IX" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Storage-stable blood coagulation factor acting in the intrinsic pathway of blood coagulation. Its activated form, IXa, forms a complex with factor VIII and calcium on platelet factor 3 to activate factor X to Xa. Deficiency of factor IX results in HEMOPHILIA B (Christmas Disease).
| Descriptor ID |
D005164
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| MeSH Number(s) |
D08.622.355 D12.776.124.125.375 D23.119.375
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| Concept/Terms |
Factor IX- Factor IX
- Factor Nine
- Autoprothrombin II
- Christmas Factor
- Factor IX Fraction
- Plasma Thromboplastin Component
- Blood Coagulation Factor IX
- Factor IX Complex
- Factor 9
- Coagulation Factor IX
- Factor IX, Coagulation
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Below are MeSH descriptors whose meaning is more general than "Factor IX".
Below are MeSH descriptors whose meaning is more specific than "Factor IX".
This graph shows the total number of publications written about "Factor IX" by people in this website by year, and whether "Factor IX" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 2 | 1 | 3 | | 1996 | 0 | 1 | 1 | | 1997 | 2 | 0 | 2 | | 1999 | 0 | 2 | 2 | | 2003 | 1 | 0 | 1 | | 2004 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 | | 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Factor IX" by people in Profiles.
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Plautz WE, Sekhar Pilli VS, Cooley BC, Chattopadhyay R, Westmark PR, Getz T, Paul D, Bergmeier W, Sheehan JP, Majumder R. Anticoagulant Protein S Targets the Factor IXa Heparin-Binding Exosite to Prevent Thrombosis. Arterioscler Thromb Vasc Biol. 2018 04; 38(4):816-828.
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Getz TM, Piatt R, Petrich BG, Monroe D, Mackman N, Bergmeier W. Novel mouse hemostasis model for real-time determination of bleeding time and hemostatic plug composition. J Thromb Haemost. 2015 Mar; 13(3):417-25.
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Levi M, Moore KT, Castillejos CF, Kubitza D, Berkowitz SD, Goldhaber SZ, Raghoebar M, Patel MR, Weitz JI, Levy JH. Comparison of three-factor and four-factor prothrombin complex concentrates regarding reversal of the anticoagulant effects of rivaroxaban in healthy volunteers. J Thromb Haemost. 2014 Sep; 12(9):1428-36.
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Monroe DM, Hoffman M, Roberts HR, Hedner U. Progressive improvement in wound healing with increased therapy in haemophilia B mice. Haemophilia. 2013 Nov; 19(6):926-32.
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Branchford BR, Monahan PE, Di Paola J. New developments in the treatment of pediatric hemophilia and bleeding disorders. Curr Opin Pediatr. 2013 Feb; 25(1):23-30.
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Monahan PE, Di Paola J. Recombinant factor IX for clinical and research use. Semin Thromb Hemost. 2010 Jul; 36(5):498-509.
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McDonald A, Hoffman M, Hedner U, Roberts HR, Monroe DM. Restoring hemostatic thrombin generation at the time of cutaneous wounding does not normalize healing in hemophilia B. J Thromb Haemost. 2007 Aug; 5(8):1577-83.
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Gabriel DA, Li X, Monroe DM, Roberts HR. Recombinant human factor VIIa (rFVIIa) can activate factor FIX on activated platelets. J Thromb Haemost. 2004 Oct; 2(10):1816-22.
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Shapiro AD, Di Paola J, Cohen A, Pasi KJ, Heisel MA, Blanchette VS, Abshire TC, Hoots WK, Lusher JM, Negrier C, Rothschild C, Roth DA. The safety and efficacy of recombinant human blood coagulation factor IX in previously untreated patients with severe or moderately severe hemophilia B. Blood. 2005 Jan 15; 105(2):518-25.
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Di Paola J. Product selection issues in the management of hemophilia B. Blood Coagul Fibrinolysis. 2004 Jun; 15 Suppl 2:S17-8.
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