 Complement C2
"Complement C2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A component of the CLASSICAL COMPLEMENT PATHWAY. C2 is cleaved by activated COMPLEMENT C1S into COMPLEMENT C2B and COMPLEMENT C2A. C2a, the COOH-terminal fragment containing a SERINE PROTEASE, combines with COMPLEMENT C4B to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE).
| Descriptor ID |
D003175
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| MeSH Number(s) |
D12.776.124.486.274.150
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| Concept/Terms |
Complement C2- Complement C2
- C2, Complement
- Complement 2
- Complement Component 2
- Component 2, Complement
- C2 Complement
- Complement, C2
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Below are MeSH descriptors whose meaning is more general than "Complement C2".
Below are MeSH descriptors whose meaning is more specific than "Complement C2".
This graph shows the total number of publications written about "Complement C2" by people in this website by year, and whether "Complement C2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 1 | 0 | 1 | | 2011 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement C2" by people in Profiles.
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Fan X, McCullough RL, Huang E, Bellar A, Kim A, Poulsen KL, McClain CJ, Mitchell M, McCullough AJ, Radaeva S, Barton B, Szabo G, Dasarathy S, Rotroff DM, Nagy LE. Diagnostic and Prognostic Significance of Complement in Patients With Alcohol-Associated Hepatitis. Hepatology. 2021 03; 73(3):983-997.
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Li Q, Li YX, Stahl GL, Thurman JM, He Y, Tong HH. Essential role of factor B of the alternative complement pathway in complement activation and opsonophagocytosis during acute pneumococcal otitis media in mice. Infect Immun. 2011 Jul; 79(7):2578-85.
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Tong HH, Li YX, Stahl GL, Thurman JM. Enhanced susceptibility to acute pneumococcal otitis media in mice deficient in complement C1qa, factor B, and factor B/C2. Infect Immun. 2010 Mar; 78(3):976-83.
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Repine JE, Davies SF, Hoidal JR, Friend PS. Effect of C2-deficiency on the bactericidal activity and chemiluminescence responses of human neutrophils in vitro. Chest. 1979 Feb; 75(2 Suppl):252-4.
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Repine JE, Clawson CC, Friend PS. Influence of a deficiency of the second component of complement on the bactericidal activity of neutrophils in vitro. J Clin Invest. 1977 May; 59(5):802-9.
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Friend P, Repine JE, Clawson CC, Michael AF. Deficiency of the second component of complement (C2) with chronic vasculitis. Ann Intern Med. 1975 Dec; 83(6):813-6.
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