 Complement C9
"Complement C9" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 63-kDa serum glycoprotein encoded by gene C9. Monomeric C9 (mC9) binds the C5b-8 complex to form C5b-9 which catalyzes the polymerization of C9 forming C5b-p9 (MEMBRANE ATTACK COMPLEX) and transmembrane channels leading to lysis of the target cell. Patients with C9 deficiency suffer from recurrent bacterial infections.
| Descriptor ID |
D003186
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| MeSH Number(s) |
D12.776.124.486.274.850
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| Concept/Terms |
Complement C9- Complement C9
- C9, Complement
- Complement 9
- Complement Component 9
- Component 9, Complement
- C9 Complement
- Complement, C9
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Below are MeSH descriptors whose meaning is more general than "Complement C9".
Below are MeSH descriptors whose meaning is more specific than "Complement C9".
This graph shows the total number of publications written about "Complement C9" by people in this website by year, and whether "Complement C9" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement C9" by people in Profiles.
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Thurman JM, Ljubanovic D, Edelstein CL, Gilkeson GS, Holers VM. Lack of a functional alternative complement pathway ameliorates ischemic acute renal failure in mice. J Immunol. 2003 Feb 01; 170(3):1517-23.
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Sawant-Mane S, Piddlesden SJ, Morgan BP, Holers VM, Koski CL. CD59 homologue regulates complement-dependent cytolysis of rat Schwann cells. J Neuroimmunol. 1996 Sep; 69(1-2):63-71.
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Kroshus TJ, Bolman RM, Dalmasso AP, Rollins SA, Guilmette ER, Williams BL, Squinto SP, Fodor WL. Expression of human CD59 in transgenic pig organs enhances organ survival in an ex vivo xenogeneic perfusion model. Transplantation. 1996 May 27; 61(10):1513-21.
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Blaser MJ, Smith PF, Repine JE, Joiner KA. Pathogenesis of Campylobacter fetus infections. Failure of encapsulated Campylobacter fetus to bind C3b explains serum and phagocytosis resistance. J Clin Invest. 1988 May; 81(5):1434-44.
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