 Complement Inactivating Agents
"Complement Inactivating Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds that negatively regulate the cascade process of COMPLEMENT ACTIVATION. Uncontrolled complement activation and resulting cell lysis is potentially dangerous for the host.
| Descriptor ID |
D051056
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| MeSH Number(s) |
D27.505.696.477.656.500
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| Concept/Terms |
Complement Inactivating Agents- Complement Inactivating Agents
- Agents, Complement Inactivating
- Inactivating Agents, Complement
- Complement Inhibitors
- Inhibitors, Complement
- Complement Inhibiting Agents
- Agents, Complement Inhibiting
- Inhibiting Agents, Complement
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Below are MeSH descriptors whose meaning is more general than "Complement Inactivating Agents".
Below are MeSH descriptors whose meaning is more specific than "Complement Inactivating Agents".
This graph shows the total number of publications written about "Complement Inactivating Agents" by people in this website by year, and whether "Complement Inactivating Agents" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 2 | 0 | 2 | | 2010 | 1 | 0 | 1 | | 2013 | 3 | 1 | 4 | | 2014 | 1 | 0 | 1 | | 2016 | 3 | 0 | 3 | | 2017 | 2 | 1 | 3 | | 2018 | 1 | 0 | 1 | | 2019 | 1 | 1 | 2 | | 2020 | 4 | 1 | 5 | | 2021 | 1 | 2 | 3 | | 2023 | 0 | 4 | 4 | | 2024 | 0 | 2 | 2 | | 2025 | 5 | 0 | 5 |
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Below are the most recent publications written about "Complement Inactivating Agents" by people in Profiles.
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Liu F, Wawersik S, Tomlinson S, Thurman JM, Holers VM. Tissue-targeted regulators of complement for amelioration of human disease: rationale and novel therapeutic strategies. J Immunol. 2025 Sep 01; 214(9):2138-2149.
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Li Y, Jacques S, Gaikwad H, Nebbia M, Banda NK, Holers VM, Tomlinson SA, Scheinman RI, Monte A, Saba L, Lasda E, Hasselberth J, Busquet N, Zelek WM, Moghimi SM, Simberg D. Enhanced immunocompatibility and hemocompatibility of nanomedicines across multiple species using complement pathway inhibitors. Sci Adv. 2025 Jul 11; 11(28):eadw1731.
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Guaschino V, Santarsiero D, Gastoldi S, Thurman JM, Holers VM, Violette SM, Liu F, Fahnoe KC, Guarinoni C, Benigni A, Remuzzi G, Noris M, Aiello S. C3d-targeted complement inhibitors to correct complement dysregulation in aHUS patients. Front Immunol. 2025; 16:1620996.
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Given KS, Acker EG, Macklin WB, Carlin D, Owens GP, Bennett JL. Complement inhibition rapidly blocks lesion extension and facilitates remyelination in neuromyelitis optica. Acta Neuropathol Commun. 2025 06 12; 13(1):129.
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Holers VM. Systemic lupus erythematosus as the paradigm for understanding the complex immune relationships and therapeutic opportunities for targeting complement in autoimmune diseases. Immunobiology. 2025 05; 230(3):152915.
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Vivarelli M, Barratt J, Beck LH, Fakhouri F, Gale DP, Goicoechea de Jorge E, Mosca M, Noris M, Pickering MC, Susztak K, Thurman JM, Cheung M, King JM, Jadoul M, Winkelmayer WC, Smith RJH. The role of complement in kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2024 Sep; 106(3):369-391.
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Andersen JF, Lei H, Strayer EC, Pham V, Ribeiro JMC. Mechanism of complement inhibition by a mosquito protein revealed through cryo-EM. Commun Biol. 2024 05 27; 7(1):649.
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Antonucci L, Thurman JM, Vivarelli M. Complement inhibitors in pediatric kidney diseases: new therapeutic opportunities. Pediatr Nephrol. 2024 May; 39(5):1387-1404.
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Mauch TJ, Chladek MR, Cataland S, Chaturvedi S, Dixon BP, Garlo K, Gasteyger C, Java A, Leguizamo J, Lloyd-Price L, Pham TP, Symonds T, Tomazos I, Wang Y. Treatment preference and quality of life impact: ravulizumab vs eculizumab for atypical hemolytic uremic syndrome. J Comp Eff Res. 2023 09; 12(9):e230036.
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Hatchell D, Alshareef M, Vasas T, Guglietta S, Borucki D, Guo C, Mallah K, Eskandari R, Tomlinson S. A role for P-selectin and complement in the pathological sequelae of germinal matrix hemorrhage. J Neuroinflammation. 2023 Jun 16; 20(1):143.
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