 Complement Membrane Attack Complex
"Complement Membrane Attack Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the "membrane attack complex" or MAC.
| Descriptor ID |
D015938
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| MeSH Number(s) |
D12.776.124.486.274.930
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| Concept/Terms |
Complement Membrane Attack Complex- Complement Membrane Attack Complex
- C5b-8-poly-C9
- C5b 8 poly C9
- Terminal Complement Complex
- Complement Complex, Terminal
- Complex, Terminal Complement
- Complement Complex C5b-9
- Complement Complex C5b 9
- Cytolytic Terminal Complement Complex
- Membrane Attack Complex
- C 5b-9
- C5b-9
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Below are MeSH descriptors whose meaning is more general than "Complement Membrane Attack Complex".
Below are MeSH descriptors whose meaning is more specific than "Complement Membrane Attack Complex".
This graph shows the total number of publications written about "Complement Membrane Attack Complex" by people in this website by year, and whether "Complement Membrane Attack Complex" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1996 | 1 | 0 | 1 | | 2006 | 2 | 0 | 2 | | 2009 | 0 | 2 | 2 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2016 | 0 | 3 | 3 | | 2018 | 0 | 1 | 1 | | 2019 | 1 | 1 | 2 | | 2020 | 1 | 0 | 1 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement Membrane Attack Complex" by people in Profiles.
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Green-Fulgham SM, Lacagnina MJ, Willcox KF, Li J, Harland ME, Ciena AP, Rocha IRC, Ball JB, Dreher RA, Zuberi YA, Dragavon JM, Chacur M, Maier SF, Watkins LR, Grace PM. Voluntary wheel running prevents formation of membrane attack complexes and myelin degradation after peripheral nerve injury. Brain Behav Immun. 2024 01; 115:419-431.
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Yuan X, Yu J, Gerber G, Chaturvedi S, Cole M, Chen H, Metjian A, Sperati CJ, Braunstein EM, Brodsky RA. Ex vivo assays to detect complement activation in complementopathies. Clin Immunol. 2020 12; 221:108616.
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Parry J, Hwang J, Stahel CF, Henderson C, Nadeau J, Stacey S, Beauchamp K, Moore EE, Stahel PF. Soluble terminal complement activation fragment sC5b-9: a new serum biomarker for traumatic brain injury? Eur J Trauma Emerg Surg. 2021 Oct; 47(5):1491-1497.
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Faria B, Gaya da Costa M, Poppelaars F, Franssen CFM, Pestana M, Berger SP, Daha MR, Gaillard CAJM, Seelen MA. Administration of Intravenous Iron Formulations Induces Complement Activation in-vivo. Front Immunol. 2019; 10:1885.
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Lynch AM, Mandava N, Patnaik JL, Frazer-Abel AA, Wagner BD, Palestine AG, Mathias MT, Siringo FS, Cathcart JN, Holers VM. Systemic activation of the complement system in patients with advanced age-related macular degeneration. Eur J Ophthalmol. 2020 Sep; 30(5):1061-1068.
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Jalal D, Renner B, Laskowski J, Stites E, Cooper J, Valente K, You Z, Perrenoud L, Le Quintrec M, Muhamed I, Christians U, Klawitter J, Lindorfer MA, Taylor RP, Holers VM, Thurman JM. Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease. J Am Heart Assoc. 2018 07 13; 7(14).
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Hempel JC, Poppelaars F, Gaya da Costa M, Franssen CF, de Vlaam TP, Daha MR, Berger SP, Seelen MA, Gaillard CA. Distinct in vitro Complement Activation by Various Intravenous Iron Preparations. Am J Nephrol. 2017; 45(1):49-59.
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Poppelaars F, Gaya da Costa M, Berger SP, Assa S, Meter-Arkema AH, Daha MR, van Son WJ, Franssen CF, Seelen MA. Strong predictive value of mannose-binding lectin levels for cardiovascular risk of hemodialysis patients. J Transl Med. 2016 08 05; 14(1):236.
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Buchman S, Bandyopadhyay S, Baccon J, Wicklund M. A surprising case of inclusion body myositis with positive endomysial C5b-9 staining. Muscle Nerve. 2016 06; 53(6):991-2.
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Jodele S, Fukuda T, Vinks A, Mizuno K, Laskin BL, Goebel J, Dixon BP, Teusink A, Pluthero FG, Lu L, Licht C, Davies SM. Eculizumab therapy in children with severe hematopoietic stem cell transplantation-associated thrombotic microangiopathy. Biol Blood Marrow Transplant. 2014 Apr; 20(4):518-25.
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