 Complement C4
"Complement C4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A glycoprotein that is important in the activation of CLASSICAL COMPLEMENT PATHWAY. C4 is cleaved by the activated COMPLEMENT C1S into COMPLEMENT C4A and COMPLEMENT C4B.
| Descriptor ID |
D003181
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| MeSH Number(s) |
D12.776.124.486.274.350
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| Concept/Terms |
Complement C4- Complement C4
- C4, Complement
- Complement Component 4
- Component 4, Complement
- Complement 4
- C4 Complement
- Complement, C4
- C4 Complement Component
- Complement Component, C4
- Component, C4 Complement
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Below are MeSH descriptors whose meaning is more general than "Complement C4".
Below are MeSH descriptors whose meaning is more specific than "Complement C4".
This graph shows the total number of publications written about "Complement C4" by people in this website by year, and whether "Complement C4" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 | | 2006 | 1 | 1 | 2 | | 2008 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2017 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 | | 2021 | 0 | 2 | 2 | | 2022 | 1 | 0 | 1 | | 2024 | 1 | 0 | 1 | | 2025 | 1 | 1 | 2 | | 2026 | 1 | 1 | 2 |
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Below are the most recent publications written about "Complement C4" by people in Profiles.
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Sánchez-Carbonell M, Bolshakova S, Ávila-Pagán JE, Sabir YA, Griffin-Derr C, Stich DG, Cieslewicz SV, Carmen Sifuentes SE, Phadke RA, Brack A, Hasche-Kluender A, Caley P, Dias C, Cruz-Martín A. Sparse neuronal C4 elevation induces network-wide transcriptomic and lipid-droplet remodeling in the cortical microenvironment. PLoS Comput Biol. 2026 Oct; 22(10):e1014871.
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Mickael C, Fonseca Balladares DC, Kumar R, Lee MH, Nolan K, Sanders L, Tuscan KJ, Prasad R, Londono P, Oliveira FP, Pyper KB, Molofsky AB, Tuder RM, Stenmark KR, Graham BB. Role of CD4+ T cell mannose binding lectin in Schistosoma-induced pulmonary hypertension. JCI Insight. 2026 Sep 08; 11(17).
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Williams J, Marin WM, Wade KJ, Suseno R, Kizer K, Caillier S, Augusto DG, Norman PJ, Hollenbach JA. Copy number variation at the complement C4 locus is associated with risk for multiple sclerosis. Mult Scler. 2025 Sep; 31(10):1243-1246.
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Donado CA, Theisen E, Zhang F, Nathan A, Fairfield ML, Rupani KV, Jones D, Johannes KP, Raychaudhuri S, Dwyer DF, Jonsson AH, Brenner MB. Granzyme K activates the entire complement cascade. Nature. 2025 05; 641(8061):211-221.
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Phadke RA, Brack A, Fournier LA, Kruzich E, Sha M, Picard I, Johnson C, Stroumbakis D, Salgado M, Yeung C, Escude Velasco B, Liu YY, Cruz-Martín A. The schizophrenia risk gene C4 induces pathological synaptic loss by impairing AMPAR trafficking. Mol Psychiatry. 2025 02; 30(2):796-809.
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Schaid TR, Hansen KC, Sauaia A, Moore EE, DeBot M, Cralley AL, Erickson C, Silliman CC, Banerjee A, Ghasabyan A, Jones K, Lacroix I, Mitra S, D'Alessandro A, Cohen MJ. Postinjury complement C4 activation is associated with adverse outcomes and is potentially influenced by plasma resuscitation. J Trauma Acute Care Surg. 2022 11 01; 93(5):588-596.
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Goel K, Maleki-Fischbach M, George MP, Kim D, Richards J, Wise RA, Serban KA. A 56-Year-Old Man With Emphysema, Rash, and Arthralgia. Chest. 2021 11; 160(5):e513-e518.
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Toutonji A, Mandava M, Guglietta S, Tomlinson S. Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study. Acta Neuropathol Commun. 2021 07 19; 9(1):126.
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Laskowski J, Thurman JM. Complement Detection in Mouse Kidneys by Immunofluorescence. Methods Mol Biol. 2021; 2227:179-189.
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Fan X, McCullough RL, Huang E, Bellar A, Kim A, Poulsen KL, McClain CJ, Mitchell M, McCullough AJ, Radaeva S, Barton B, Szabo G, Dasarathy S, Rotroff DM, Nagy LE. Diagnostic and Prognostic Significance of Complement in Patients With Alcohol-Associated Hepatitis. Hepatology. 2021 03; 73(3):983-997.
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