 Properdin
"Properdin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.
| Descriptor ID |
D011414
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| MeSH Number(s) |
D12.776.124.486.274.965 D12.776.124.790.223.624 D12.776.377.715.182.624
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| Concept/Terms |
Properdin- Properdin
- Complement Factor P
- Factor P, Complement
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Below are MeSH descriptors whose meaning is more general than "Properdin".
Below are MeSH descriptors whose meaning is more specific than "Properdin".
This graph shows the total number of publications written about "Properdin" by people in this website by year, and whether "Properdin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 1 | 2 | 3 | | 2020 | 1 | 0 | 1 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Properdin" by people in Profiles.
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Faria B, Gaya da Costa M, Meter-Arkema AH, Berger SP, Lima C, P?go C, van den Born J, Franssen CF, Daha MR, Pestana M, Seelen MA, Poppelaars F. Systemic and local complement activation in peritoneal dialysis patients via conceivably distinct pathways. Perit Dial Int. 2024 01; 44(1):37-47.
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Chen JY, Galwankar NS, Emch HN, Menon SS, Cortes C, Thurman JM, Merrill SA, Brodsky RA, Ferreira VP. Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation. Front Immunol. 2020; 11:1460.
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Hempel JC, Poppelaars F, Gaya da Costa M, Franssen CF, de Vlaam TP, Daha MR, Berger SP, Seelen MA, Gaillard CA. Distinct in vitro Complement Activation by Various Intravenous Iron Preparations. Am J Nephrol. 2017; 45(1):49-59.
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Poppelaars F, Gaya da Costa M, Berger SP, Assa S, Meter-Arkema AH, Daha MR, van Son WJ, Franssen CF, Seelen MA. Strong predictive value of mannose-binding lectin levels for cardiovascular risk of hemodialysis patients. J Transl Med. 2016 08 05; 14(1):236.
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Blatt AZ, Saggu G, Kulkarni KV, Cortes C, Thurman JM, Ricklin D, Lambris JD, Valenzuela JG, Ferreira VP. Properdin-Mediated C5a Production Enhances Stable Binding of Platelets to Granulocytes in Human Whole Blood. J Immunol. 2016 06 01; 196(11):4671-4680.
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Palestine AG, Klemperer MR. In vivo activation of properdin factor B in normotensive bacteremic individuals. J Immunol. 1976 Aug; 117(2):703-5.
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BALTCH AL, OSBORNE W, CANARILE L, HASSIRDJIAN A, BUNN PA. Serum properdin, complement and agglutinin changes in dogs with staphylococcal bacteremia. J Immunol. 1962 Mar; 88:361-8.
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BALTCH AL, HASSIRDJIAN A, OSBORNE W, BUNN PA. Comparison of properdin titers in sera of normal subjects and patients with leukemia and lymphoma by zymosan and bacteriophage assavs. J Lab Clin Med. 1961 Mar; 57:420-7.
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