 Factor IXa
"Factor IXa" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Activated form of factor IX. This activation can take place via the intrinsic pathway of blood coagulation by the action of factor XIa and calcium, or via the extrinsic pathway by the action of factor VIIa, thromboplastin, and calcium. Factor IXa serves to activate factor X to Xa by cleaving the arginyl-leucine peptide bond in factor X.
| Descriptor ID |
D015949
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| MeSH Number(s) |
D08.811.277.656.300.760.310 D08.811.277.656.959.350.310 D12.776.124.125.375.310 D23.119.375.310
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| Concept/Terms |
Factor IXa- Factor IXa
- Coagulation Factor IXa
- Factor IXa, Coagulation
- Blood Coagulation Factor IX, Activated
- Factor IX, Activated
- Activated Factor IX
- Factor 9A
- Factor Nine A
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Below are MeSH descriptors whose meaning is more general than "Factor IXa".
Below are MeSH descriptors whose meaning is more specific than "Factor IXa".
This graph shows the total number of publications written about "Factor IXa" by people in this website by year, and whether "Factor IXa" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 | | 1997 | 0 | 1 | 1 | | 1998 | 1 | 1 | 2 | | 2004 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Factor IXa" by people in Profiles.
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Plautz WE, Sekhar Pilli VS, Cooley BC, Chattopadhyay R, Westmark PR, Getz T, Paul D, Bergmeier W, Sheehan JP, Majumder R. Anticoagulant Protein S Targets the Factor IXa Heparin-Binding Exosite to Prevent Thrombosis. Arterioscler Thromb Vasc Biol. 2018 04; 38(4):816-828.
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Gabriel DA, Li X, Monroe DM, Roberts HR. Recombinant human factor VIIa (rFVIIa) can activate factor FIX on activated platelets. J Thromb Haemost. 2004 Oct; 2(10):1816-22.
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Roberts HR, Monroe DM, Oliver JA, Chang JY, Hoffman M. Newer concepts of blood coagulation. Haemophilia. 1998 Jul; 4(4):331-4.
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Hoffman M, Monroe DM, Roberts HR. Activated factor VII activates factors IX and X on the surface of activated platelets: thoughts on the mechanism of action of high-dose activated factor VII. Blood Coagul Fibrinolysis. 1998 Mar; 9 Suppl 1:S61-5.
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Chang JY, Monroe DM, Stafford DW, Brinkhous KM, Roberts HR. Replacing the first epidermal growth factor-like domain of factor IX with that of factor VII enhances activity in vitro and in canine hemophilia B. J Clin Invest. 1997 Aug 15; 100(4):886-92.
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Hoffman M, Monroe DM, Oliver JA, Roberts HR. Factors IXa and Xa play distinct roles in tissue factor-dependent initiation of coagulation. Blood. 1995 Sep 01; 86(5):1794-801.
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Hoffman M, Monroe DM, Roberts HR. Platelet activation in patients with thrombotic thrombocytopenic purpura. Am J Hematol. 1993 Feb; 42(2):182-5.
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Hoffman M, Monroe DM, Roberts HR. Coagulation factor IXa binding to activated platelets and platelet-derived microparticles: a flow cytometric study. Thromb Haemost. 1992 Jul 06; 68(1):74-8.
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Rawala-Sheikh R, Ahmad SS, Monroe DM, Roberts HR, Walsh PN. Role of gamma-carboxyglutamic acid residues in the binding of factor IXa to platelets and in factor-X activation. Blood. 1992 Jan 15; 79(2):398-405.
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Ahmad SS, Rawala-Sheikh R, Monroe DM, Roberts HR, Walsh PN. Comparative platelet binding and kinetic studies with normal and variant factor IXa molecules. J Biol Chem. 1990 Dec 05; 265(34):20907-11.
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