 Complement Pathway, Alternative
"Complement Pathway, Alternative" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Complement activation initiated by the interaction of microbial ANTIGENS with COMPLEMENT C3B. When COMPLEMENT FACTOR B binds to the membrane-bound C3b, COMPLEMENT FACTOR D cleaves it to form alternative C3 CONVERTASE (C3BBB) which, stabilized by COMPLEMENT FACTOR P, is able to cleave multiple COMPLEMENT C3 to form alternative C5 CONVERTASE (C3BBB3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
| Descriptor ID |
D003170
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| MeSH Number(s) |
G12.274.695
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| Concept/Terms |
Complement Pathway, Alternative- Complement Pathway, Alternative
- Alternative Complement Pathway
- Alternative Complement Activation Pathway
- Properdin Pathway
- Complement Activation Pathway, Alternative
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Below are MeSH descriptors whose meaning is more general than "Complement Pathway, Alternative".
Below are MeSH descriptors whose meaning is more specific than "Complement Pathway, Alternative".
This graph shows the total number of publications written about "Complement Pathway, Alternative" by people in this website by year, and whether "Complement Pathway, Alternative" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 | | 2003 | 2 | 1 | 3 | | 2004 | 2 | 0 | 2 | | 2005 | 1 | 0 | 1 | | 2006 | 3 | 0 | 3 | | 2007 | 4 | 1 | 5 | | 2008 | 4 | 0 | 4 | | 2009 | 3 | 1 | 4 | | 2010 | 2 | 2 | 4 | | 2011 | 5 | 1 | 6 | | 2012 | 3 | 0 | 3 | | 2013 | 5 | 1 | 6 | | 2014 | 1 | 2 | 3 | | 2016 | 2 | 0 | 2 | | 2017 | 2 | 1 | 3 | | 2018 | 1 | 2 | 3 | | 2019 | 1 | 0 | 1 | | 2020 | 1 | 1 | 2 | | 2022 | 2 | 2 | 4 | | 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "Complement Pathway, Alternative" by people in Profiles.
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Jalal DI, Thurman JM, Smith RJ. Chronic kidney disease enhances alternative pathway activity: a new paradigm. J Clin Invest. 2025 May 01; 135(9).
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McCaleb ML, Hughes SG, Grossman TR, Frazer-Abel A, Jung B, Yin L, Henry SP, Monia BP, Schneider E, Geary R, Brice GT. Inhibiting the alternative pathway of complement by reducing systemic complement factor B: Randomized, double-blind, placebo-controlled phase 1 studies with Sefaxersen. Immunobiology. 2025 03; 230(2):152876.
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Harrison RA, Harris CL, Thurman JM. The complement alternative pathway in health and disease-activation or amplification? Immunol Rev. 2023 01; 313(1):6-14.
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Thurman JM, Harrison RA. The susceptibility of the kidney to alternative pathway activation-A hypothesis. Immunol Rev. 2023 01; 313(1):327-338.
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Thurman JM, Fremeaux-Bacchi V. Alternative pathway diagnostics. Immunol Rev. 2023 01; 313(1):225-238.
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Holers VM. Contributions of animal models to mechanistic understandings of antibody-dependent disease and roles of the amplification loop. Immunol Rev. 2023 01; 313(1):181-193.
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Samuels JM, Coleman JR, Moore EE, Bartley M, Vigneshwar N, Cohen M, Silliman CC, Sauaia A, Banerjee A. Alternative Complement Pathway Activation Provokes a Hypercoagulable State with Diminished Fibrinolysis. Shock. 2020 05; 53(5):560-565.
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Holers VM, Borodovsky A, Scheinman RI, Ho N, Ramirez JR, Dob? J, G?l P, Lindenberger J, Hansen AG, Desai D, Pihl R, Thiel S, Banda NK. Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D. Front Immunol. 2020; 11:201.
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Frid MG, McKeon BA, Thurman JM, Maron BA, Li M, Zhang H, Kumar S, Sullivan T, Laskowsky J, Fini MA, Hu S, Tuder RM, Gandjeva A, Wilkins MR, Rhodes CJ, Ghataorhe P, Leopold JA, Wang RS, Holers VM, Stenmark KR. Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension. Am J Respir Crit Care Med. 2020 01 15; 201(2):224-239.
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Laskowski J, Philbrook HT, Parikh CR, Thurman JM. Urine complement activation fragments are increased in patients with kidney injury after cardiac surgery. Am J Physiol Renal Physiol. 2019 09 01; 317(3):F650-F657.
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