 Complement C1
"Complement C1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY. It is a calcium-dependent trimolecular complex made up of three subcomponents: COMPLEMENT C1Q; COMPLEMENT C1R; and COMPLEMENT C1S at 1:2:2 ratios. When the intact C1 binds to at least two antibodies (involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of COMPLEMENT ACTIVATION.
| Descriptor ID |
D003172
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| MeSH Number(s) |
D12.776.124.486.274.050
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| Concept/Terms |
Complement C1- Complement C1
- C1, Complement
- C1 Complement
- Complement, C1
- Complement 1
- Complement Component 1
- Component 1, Complement
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Below are MeSH descriptors whose meaning is more general than "Complement C1".
Below are MeSH descriptors whose meaning is more specific than "Complement C1".
This graph shows the total number of publications written about "Complement C1" by people in this website by year, and whether "Complement C1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Complement C1" by people in Profiles.
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Ho AWS, Fukuzawa T, Koga H, Ohmine K, Kawauchi H, Muraoka M, Ikuta Y, Gupta G, Okuda M, Onami I, Ayabe M, Takeiri A, Konishi H, Sugawara Y, Usami S, Ito E, Shibahara N, Ozeki K, Wada Y, Hirako A, Takahashi N, Sampei Z, Haraya K, Murao N, Fujii T, Torizawa T, Shimada H, Igawa T. Long lasting complement neutralisation by RAY121, an engineered anti-C1s antibody with C1q displacement function. EBioMedicine. 2025 Dec; 122:106009.
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Schocket AL, Carr RI, Hardtke MA. A comparison of I125 Clq binding, Raji cell binding, and lymphocytotoxic activity in multiple sclerosis. Clin Immunol Immunopathol. 1980 Nov; 17(3):477-81.
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Phanuphak P, Kohler PF, Stanford RE, Schocket AL, Carr RI, Claman HN. Vasculitis in chronic urticaria. J Allergy Clin Immunol. 1980 Jun; 65(6):436-44.
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