 Mannose-Binding Protein-Associated Serine Proteases
"Mannose-Binding Protein-Associated Serine Proteases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Serum serine proteases which participate in COMPLEMENT ACTIVATION. They are activated when complexed with the MANNOSE-BINDING LECTIN, therefore also known as Mannose-binding protein-Associated Serine Proteases (MASPs). They cleave COMPLEMENT C4 and COMPLEMENT C2 to form C4b2a, the CLASSICAL PATHWAY C3 CONVERTASE.
| Descriptor ID |
D050606
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| MeSH Number(s) |
D08.811.277.656.300.760.501 D08.811.277.656.959.350.501 D12.776.124.486.274.045.387.875
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| Concept/Terms |
Mannose-Binding Protein-Associated Serine Proteases- Mannose-Binding Protein-Associated Serine Proteases
- Mannose-Binding Protein-Associated Serine Protease
- Mannose Binding Protein Associated Serine Protease
- MBP-Associated Serine Protease
- MBP Associated Serine Protease
- Serine Protease, MBP-Associated
- MASPs
- Mannan-Binding Lectin Serine Proteases
- Mannan Binding Lectin Serine Proteases
- MBL-Associated Serine Proteases
- MBL Associated Serine Proteases
- Serine Proteases, MBL-Associated
- MASP Proteases
- Proteases, MASP
MASP-Related Protein- MASP-Related Protein
- MASP Related Protein
- Protein, MASP-Related
- MBP-Associated Serine Protease-Related Protein
- MBP Associated Serine Protease Related Protein
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Below are MeSH descriptors whose meaning is more general than "Mannose-Binding Protein-Associated Serine Proteases".
Below are MeSH descriptors whose meaning is more specific than "Mannose-Binding Protein-Associated Serine Proteases".
This graph shows the total number of publications written about "Mannose-Binding Protein-Associated Serine Proteases" by people in this website by year, and whether "Mannose-Binding Protein-Associated Serine Proteases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 1 | 0 | 1 | | 2011 | 2 | 0 | 2 | | 2014 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2019 | 0 | 1 | 1 | | 2020 | 1 | 1 | 2 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mannose-Binding Protein-Associated Serine Proteases" by people in Profiles.
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Wu LP, Ficker M, Christensen JB, Simberg D, Trohopoulos PN, Moghimi SM. Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking. Nat Commun. 2021 08 11; 12(1):4858.
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Talsma DT, Poppelaars F, Dam W, Meter-Arkema AH, Viv?s RR, G?l P, Boons GJ, Chopra P, Naggi A, Seelen MA, Berger SP, Daha MR, Stegeman CA, van den Born J. MASP-2 Is a Heparin-Binding Protease; Identification of Blocking Oligosaccharides. Front Immunol. 2020; 11:732.
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Holers VM, Borodovsky A, Scheinman RI, Ho N, Ramirez JR, Dob? J, G?l P, Lindenberger J, Hansen AG, Desai D, Pihl R, Thiel S, Banda NK. Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D. Front Immunol. 2020; 11:201.
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Serban KA, Mikosz A, Strange C, Janciauskiene SM, Stolk J, Jonigk D, Sandhaus RA, Petrache I. Lectin Complement Pathway in Emphysema. Am J Respir Crit Care Med. 2019 03 01; 199(5):659-661.
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Banda NK, Acharya S, Scheinman RI, Mehta G, Takahashi M, Endo Y, Zhou W, Farrar CA, Sacks SH, Fujita T, Sekine H, Holers VM. Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein-Associated Serine Protease 2. J Immunol. 2017 09 01; 199(5):1835-1845.
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Sinha VK, Sharma OP, Kumar MS. Insight into the intermolecular recognition mechanism involved in complement component 4 activation through serine protease-trypsin. J Biomol Struct Dyn. 2018 02; 36(3):575-589.
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Banda NK, Acharya S, Scheinman RI, Mehta G, Coulombe M, Takahashi M, Sekine H, Thiel S, Fujita T, Holers VM. Mannan-Binding Lectin-Associated Serine Protease 1/3 Cleavage of Pro-Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference-Mediated Gene Silencing. J Immunol. 2016 11 01; 197(9):3680-3694.
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Banda NK, Mehta G, Kjaer TR, Takahashi M, Schaack J, Morrison TE, Thiel S, Arend WP, Holers VM. Essential role for the lectin pathway in collagen antibody-induced arthritis revealed through use of adenovirus programming complement inhibitor MAp44 expression. J Immunol. 2014 Sep 01; 193(5):2455-68.
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La Bonte LR, Pavlov VI, Tan YS, Takahashi K, Takahashi M, Banda NK, Zou C, Fujita T, Stahl GL. Mannose-binding lectin-associated serine protease-1 is a significant contributor to coagulation in a murine model of occlusive thrombosis. J Immunol. 2012 Jan 15; 188(2):885-91.
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Banda NK, Takahashi M, Takahashi K, Stahl GL, Hyatt S, Glogowska M, Wiles TA, Endo Y, Fujita T, Holers VM, Arend WP. Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement. Mol Immunol. 2011 Oct; 49(1-2):281-9.
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