 Complement Activation
"Complement Activation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The sequential activation of serum COMPLEMENT PROTEINS to create the COMPLEMENT MEMBRANE ATTACK COMPLEX. Factors initiating complement activation include ANTIGEN-ANTIBODY COMPLEXES, microbial ANTIGENS, or cell surface POLYSACCHARIDES.
| Descriptor ID |
D003167
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| MeSH Number(s) |
G12.274
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| Concept/Terms |
Complement Activation- Complement Activation
- Activation, Complement
- Activations, Complement
- Complement Activations
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Below are MeSH descriptors whose meaning is more general than "Complement Activation".
Below are MeSH descriptors whose meaning is more specific than "Complement Activation".
This graph shows the total number of publications written about "Complement Activation" by people in this website by year, and whether "Complement Activation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 2 | 3 | | 1996 | 0 | 3 | 3 | | 1997 | 1 | 0 | 1 | | 1998 | 0 | 1 | 1 | | 1999 | 0 | 2 | 2 | | 2000 | 2 | 1 | 3 | | 2001 | 0 | 2 | 2 | | 2002 | 2 | 2 | 4 | | 2003 | 6 | 1 | 7 | | 2004 | 1 | 3 | 4 | | 2005 | 1 | 1 | 2 | | 2006 | 3 | 5 | 8 | | 2007 | 1 | 3 | 4 | | 2008 | 3 | 1 | 4 | | 2010 | 3 | 2 | 5 | | 2011 | 3 | 3 | 6 | | 2012 | 2 | 2 | 4 | | 2013 | 4 | 6 | 10 | | 2014 | 5 | 4 | 9 | | 2015 | 3 | 2 | 5 | | 2016 | 8 | 6 | 14 | | 2017 | 6 | 3 | 9 | | 2018 | 6 | 8 | 14 | | 2019 | 7 | 6 | 13 | | 2020 | 7 | 6 | 13 | | 2021 | 4 | 5 | 9 | | 2022 | 3 | 9 | 12 | | 2023 | 1 | 8 | 9 | | 2024 | 2 | 3 | 5 | | 2025 | 5 | 7 | 12 |
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Below are the most recent publications written about "Complement Activation" by people in Profiles.
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Liu F, Wawersik S, Tomlinson S, Thurman JM, Holers VM. Tissue-targeted regulators of complement for amelioration of human disease: rationale and novel therapeutic strategies. J Immunol. 2025 Sep 01; 214(9):2138-2149.
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Lynch AM, Grove NC, Wagner BD, Palestine AG, Holers VM, Frazer-Abel AA, Gnanaraj R, Lisker-Cervantes A, Patnaik JL, de Carlo Forest TE, Auer EA, McReynolds AJ, Mathias MT, Manoharan N, Rodriquez De Cordoba S, Mandava N. Dynamic Risk of Systemic Complement Activation With Time to Progression to Advanced Age-Related Macular Degeneration. JAMA Ophthalmol. 2025 Aug 01; 143(8):634-642.
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Li Y, Jacques S, Gaikwad H, Nebbia M, Banda NK, Holers VM, Tomlinson SA, Scheinman RI, Monte A, Saba L, Lasda E, Hasselberth J, Busquet N, Zelek WM, Moghimi SM, Simberg D. Enhanced immunocompatibility and hemocompatibility of nanomedicines across multiple species using complement pathway inhibitors. Sci Adv. 2025 Jul 11; 11(28):eadw1731.
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McElwee ER, Hatchell D, Alshareef M, Mallah K, Hall H, Robinson H, Eskandari R, Chang E, Sullivan S, Tomlinson S. Complement Modulation Mitigates Inflammation-Mediated Preterm Birth and Fetal Neural Inflammation. Cells. 2025 Jul 08; 14(14).
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Guaschino V, Santarsiero D, Gastoldi S, Thurman JM, Holers VM, Violette SM, Liu F, Fahnoe KC, Guarinoni C, Benigni A, Remuzzi G, Noris M, Aiello S. C3d-targeted complement inhibitors to correct complement dysregulation in aHUS patients. Front Immunol. 2025; 16:1620996.
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Poppelaars F, Holers VM, Thurman JM. Friend or foe: assessing the value of animal models for facilitating clinical breakthroughs in complement research. J Clin Invest. 2025 Jun 16; 135(12).
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Banda NK, Moreland LW, Deane KD, Simberg D, Scheinman RI, Frank RM, Seifert JA, Lau R, Pitzalis C, Lewis MJ, Holers VM. Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation. Sci Rep. 2025 Jun 04; 15(1):19633.
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Profaizer T, Saadalla A, Nandakumar V. Validation for soluble C5b-9 detection and comparative analysis of three quantification methods. J Immunol Methods. 2025 Jun; 541:113882.
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Holers VM. Systemic lupus erythematosus as the paradigm for understanding the complex immune relationships and therapeutic opportunities for targeting complement in autoimmune diseases. Immunobiology. 2025 05; 230(3):152915.
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Wheeler EA, Lenhart-Pendergrass PM, Rysavy NM, Poch KR, Caceres SM, Calhoun KM, Serban KA, Nick JA, Malcolm KC. Divergent host humoral innate immune response to the smooth-to-rough adaptation of Mycobacterium abscessus in chronic infection. Front Cell Infect Microbiol. 2025; 15:1445660.
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