 Complement Activation
"Complement Activation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The sequential activation of serum COMPLEMENT PROTEINS to create the COMPLEMENT MEMBRANE ATTACK COMPLEX. Factors initiating complement activation include ANTIGEN-ANTIBODY COMPLEXES, microbial ANTIGENS, or cell surface POLYSACCHARIDES.
| Descriptor ID |
D003167
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| MeSH Number(s) |
G12.274
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| Concept/Terms |
Complement Activation- Complement Activation
- Activation, Complement
- Activations, Complement
- Complement Activations
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Below are MeSH descriptors whose meaning is more general than "Complement Activation".
Below are MeSH descriptors whose meaning is more specific than "Complement Activation".
This graph shows the total number of publications written about "Complement Activation" by people in this website by year, and whether "Complement Activation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 3 | 3 | | 1997 | 1 | 0 | 1 | | 1998 | 0 | 1 | 1 | | 1999 | 0 | 2 | 2 | | 2000 | 2 | 1 | 3 | | 2001 | 0 | 2 | 2 | | 2002 | 2 | 2 | 4 | | 2003 | 6 | 1 | 7 | | 2004 | 1 | 3 | 4 | | 2005 | 1 | 1 | 2 | | 2006 | 3 | 5 | 8 | | 2007 | 1 | 3 | 4 | | 2008 | 3 | 1 | 4 | | 2010 | 3 | 2 | 5 | | 2011 | 3 | 3 | 6 | | 2012 | 2 | 2 | 4 | | 2013 | 4 | 6 | 10 | | 2014 | 5 | 4 | 9 | | 2015 | 3 | 2 | 5 | | 2016 | 8 | 6 | 14 | | 2017 | 6 | 3 | 9 | | 2018 | 6 | 8 | 14 | | 2019 | 7 | 6 | 13 | | 2020 | 6 | 6 | 12 | | 2021 | 4 | 5 | 9 | | 2022 | 3 | 9 | 12 | | 2023 | 1 | 8 | 9 | | 2024 | 2 | 3 | 5 | | 2025 | 4 | 9 | 13 | | 2026 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement Activation" by people in Profiles.
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Zhang H, Prasad RR, Kumar S, Li M, Jones D, Hu CJ, Mickael C, Yu YR, Tuder RM, Stenmark KR. Adventitial Niches, Complement and Inflammation in Pulmonary Vascular Disease: Current Status and Future Directions. Compr Physiol. 2026 Apr; 16(2):e70133.
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E de Carlo Forest T, Marin AI, Gill Z, Gnanaraj R, Patnaik JL, Poppelaars F, Lynch AM, Palestine AG, Mathias MT, Manoharan N, Frazer-Abel AA, Holers VM, Mandava N. Association between systemic complement levels and choroidal thickness in advanced non-neovascular age-related macular degeneration. Sci Rep. 2025 Dec 06; 16(1):1442.
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Hok KD, Rich HE, Shadid A, Gunamalai L, Weng-Mills T, Thandavarayan RA, Banda NK, Doursout MF, Restrepo MI, Shivshankar P. Functional Roles of the Complement Immune System in Cardiac Inflammation and Hypertrophy. Int J Mol Sci. 2025 Oct 12; 26(20).
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Liu F, Wawersik S, Tomlinson S, Thurman JM, Holers VM. Tissue-targeted regulators of complement for amelioration of human disease: rationale and novel therapeutic strategies. J Immunol. 2025 Sep 01; 214(9):2138-2149.
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Renner B, Laskowski J, Poppelaars F, Whelan R, Milliron K, Petr V, Blaine J, Ozekin Y, Ferreira VP, Pickering MC, Schmidt CQ, Hajjar K, Davidson A, Thurman JM. Annexin A2 interferes with complement regulation within the glomerulus. J Biol Chem. 2025 10; 301(10):110657.
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Lynch AM, Grove NC, Wagner BD, Palestine AG, Holers VM, Frazer-Abel AA, Gnanaraj R, Lisker-Cervantes A, Patnaik JL, de Carlo Forest TE, Auer EA, McReynolds AJ, Mathias MT, Manoharan N, Rodriquez De Cordoba S, Mandava N. Dynamic Risk of Systemic Complement Activation With Time to Progression to Advanced Age-Related Macular Degeneration. JAMA Ophthalmol. 2025 Aug 01; 143(8):634-642.
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Li Y, Jacques S, Gaikwad H, Nebbia M, Banda NK, Holers VM, Tomlinson SA, Scheinman RI, Monte A, Saba L, Lasda E, Hasselberth J, Busquet N, Zelek WM, Moghimi SM, Simberg D. Enhanced immunocompatibility and hemocompatibility of nanomedicines across multiple species using complement pathway inhibitors. Sci Adv. 2025 Jul 11; 11(28):eadw1731.
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McElwee ER, Hatchell D, Alshareef M, Mallah K, Hall H, Robinson H, Eskandari R, Chang E, Sullivan S, Tomlinson S. Complement Modulation Mitigates Inflammation-Mediated Preterm Birth and Fetal Neural Inflammation. Cells. 2025 Jul 08; 14(14).
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Guaschino V, Santarsiero D, Gastoldi S, Thurman JM, Holers VM, Violette SM, Liu F, Fahnoe KC, Guarinoni C, Benigni A, Remuzzi G, Noris M, Aiello S. C3d-targeted complement inhibitors to correct complement dysregulation in aHUS patients. Front Immunol. 2025; 16:1620996.
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Poppelaars F, Holers VM, Thurman JM. Friend or foe: assessing the value of animal models for facilitating clinical breakthroughs in complement research. J Clin Invest. 2025 Jun 16; 135(12).
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