 Anaphylatoxins
"Anaphylatoxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Serum peptides derived from certain cleaved COMPLEMENT PROTEINS during COMPLEMENT ACTIVATION. They induce smooth MUSCLE CONTRACTION; mast cell HISTAMINE RELEASE; PLATELET AGGREGATION; and act as mediators of the local inflammatory process. The order of anaphylatoxin activity from the strongest to the weakest is C5a, C3a, C4a, and C5a des-arginine.
| Descriptor ID |
D000706
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| MeSH Number(s) |
D12.776.124.486.274.024
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Anaphylatoxins".
Below are MeSH descriptors whose meaning is more specific than "Anaphylatoxins".
This graph shows the total number of publications written about "Anaphylatoxins" by people in this website by year, and whether "Anaphylatoxins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Anaphylatoxins" by people in Profiles.
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McCullough RL, McMullen MR, Poulsen KL, Kim A, Medof ME, Nagy LE. Anaphylatoxin Receptors C3aR and C5aR1 Are Important Factors That Influence the Impact of Ethanol on the Adipose Secretome. Front Immunol. 2018; 9:2133.
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Cotter TG, Keeling PJ, Henson PM. A monoclonal antibody-inhibiting FMLP-induced chemotaxis of human neutrophils. J Immunol. 1981 Dec; 127(6):2241-5.
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Webster RO, Zanolari B, Henson PM. Neutrophil chemotaxis in response to surface-bound C5A. Exp Cell Res. 1980 Sep; 129(1):55-62.
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Larsen GL, McCarthy K, Webster RO, Henson J, Henson PM. A differential effect of C5a and C5a des Arg in the induction of pulmonary inflammation. Am J Pathol. 1980 Jul; 100(1):179-92.
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Perez HD, Goldstein IM, Chernoff D, Webster RO, Henson PM. Chemotactic activity of C5ades Arg: evidence of a requirement for an anionic peptide 'helper factor' and inhibition by a cationic protein in serum from patients with systemic lupus erythematosus. Mol Immunol. 1980 Feb; 17(2):163-9.
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McCarthy K, Henson PM. Induction of lysosomal enzyme secretion by alveolar macrophages in response to the purified complement fragments C5a and C5a des-arg. J Immunol. 1979 Dec; 123(6):2511-7.
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