 Complement Factor I
"Complement Factor I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein, respectively. It is a 66-kDa glycoprotein that converts C3b to inactivated C3b (iC3b) followed by the release of two fragments, C3c (150-kDa) and C3dg (41-kDa). It was formerly called KAF, C3bINF, or enzyme 3b inactivator.
| Descriptor ID |
D017244
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| MeSH Number(s) |
D08.811.277.656.300.760.210 D08.811.277.656.959.350.210 D12.776.124.486.274.920.325.210
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| Concept/Terms |
Complement Factor I- Complement Factor I
- C4b-C3b-INA
- C4b C3b INA
- C3b Inactivator
- Inactivator, C3b
- C4bC3bINA
- Complement C4b-C3b Inactivator
- C4b-C3b Inactivator, Complement
- Complement C4b C3b Inactivator
- Inactivator, Complement C4b-C3b
- C3b-C4b Inactivator
- C3b C4b Inactivator
- Inactivator, C3b-C4b
- Complement 3b-Complement 4b Inactivator
- Complement 3b Complement 4b Inactivator
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Below are MeSH descriptors whose meaning is more general than "Complement Factor I".
Below are MeSH descriptors whose meaning is more specific than "Complement Factor I".
This graph shows the total number of publications written about "Complement Factor I" by people in this website by year, and whether "Complement Factor I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 | | 1995 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement Factor I" by people in Profiles.
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Marin AI, Poppelaars F, Wagner BD, Palestine AG, Patnaik JL, Holers VM, Frazer-Abel AA, Mathias MT, Manoharan N, Fonteh CN, Mandava N, Lynch AM. Sex and Age-Related Differences in Complement Factors Among Patients With Intermediate Age-Related Macular Degeneration. Transl Vis Sci Technol. 2022 05 02; 11(5):22.
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Kim YU, Kinoshita T, Molina H, Hourcade D, Seya T, Wagner LM, Holers VM. Mouse complement regulatory protein Crry/p65 uses the specific mechanisms of both human decay-accelerating factor and membrane cofactor protein. J Exp Med. 1995 Jan 01; 181(1):151-9.
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Molina H, Kinoshita T, Webster CB, Holers VM. Analysis of C3b/C3d binding sites and factor I cofactor regions within mouse complement receptors 1 and 2. J Immunol. 1994 Jul 15; 153(2):789-95.
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