Factor XIIa
"Factor XIIa" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.
| Descriptor ID |
D015956
|
| MeSH Number(s) |
D08.811.277.656.300.760.324 D08.811.277.656.959.350.324 D12.776.124.125.450.324 D23.119.450.324
|
| Concept/Terms |
Factor XIIa- Factor XIIa
- Activated Factor XII
- Factor XII, Activated
- Coagulation Factor XIIa
- Factor XIIa, Coagulation
- Blood Coagulation Factor XII, Activated
- Prekallikrein Activator
- Activator, Prekallikrein
- Factor Twelve A
- Factor 12A
|
Below are MeSH descriptors whose meaning is more general than "Factor XIIa".
Below are MeSH descriptors whose meaning is more specific than "Factor XIIa".
This graph shows the total number of publications written about "Factor XIIa" by people in this website by year, and whether "Factor XIIa" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Factor XIIa" by people in Profiles.
-
Okorie UM, Denney WS, Chatterjee MS, Neeves KB, Diamond SL. Determination of surface tissue factor thresholds that trigger coagulation at venous and arterial shear rates: amplification of 100 fM circulating tissue factor requires flow. Blood. 2008 Apr 01; 111(7):3507-13.