 Complement C3
"Complement C3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.
| Descriptor ID |
D003176
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| MeSH Number(s) |
D12.776.124.050.140 D12.776.124.486.274.250
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| Concept/Terms |
Complement C3- Complement C3
- C3, Complement
- Complement 3
- Complement Component 3
- Component 3, Complement
- C3 Complement
- Complement, C3
Complement C3 Precursor- Complement C3 Precursor
- C3 Precursor, Complement
- Precursor, Complement C3
- Pro-C3
- Pro C3
- Precursor-Complement 3
- Precursor Complement 3
- Pro-Complement 3
- Pro Complement 3
- C3 Precursor
- Precursor, C3
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Below are MeSH descriptors whose meaning is more general than "Complement C3".
Below are MeSH descriptors whose meaning is more specific than "Complement C3".
This graph shows the total number of publications written about "Complement C3" by people in this website by year, and whether "Complement C3" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 1996 | 0 | 1 | 1 | | 1997 | 2 | 1 | 3 | | 2000 | 1 | 2 | 3 | | 2001 | 2 | 2 | 4 | | 2002 | 1 | 2 | 3 | | 2003 | 1 | 3 | 4 | | 2004 | 1 | 3 | 4 | | 2005 | 0 | 3 | 3 | | 2006 | 2 | 2 | 4 | | 2007 | 2 | 2 | 4 | | 2008 | 3 | 2 | 5 | | 2009 | 0 | 2 | 2 | | 2011 | 3 | 3 | 6 | | 2012 | 1 | 2 | 3 | | 2013 | 3 | 5 | 8 | | 2014 | 2 | 1 | 3 | | 2015 | 2 | 1 | 3 | | 2016 | 4 | 1 | 5 | | 2017 | 1 | 5 | 6 | | 2018 | 3 | 1 | 4 | | 2019 | 1 | 2 | 3 | | 2020 | 1 | 3 | 4 | | 2021 | 2 | 4 | 6 | | 2022 | 2 | 2 | 4 | | 2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "Complement C3" by people in Profiles.
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Li Y, Jacques S, Gaikwad H, Wang G, Banda NK, Holers VM, Scheinman RI, Tomlinson S, Moghimi SM, Simberg D. Inhibition of acute complement responses towards bolus-injected nanoparticles using targeted short-circulating regulatory proteins. Nat Nanotechnol. 2024 Feb; 19(2):246-254.
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Antonucci L, Thurman JM, Vivarelli M. Complement inhibitors in pediatric kidney diseases: new therapeutic opportunities. Pediatr Nephrol. 2024 May; 39(5):1387-1404.
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Podos SD, Trachtman H, Appel GB, Bomback AS, Dixon BP, Wetzels JFM, Cook HT, Parikh SV, Pickering MC, Tumlin J, Langman CB, Lightstone L, Sperati CJ, Daina E, Bouman KP, Rice K, Thanassi JA, Huang M, Nester C, Remuzzi G. Baseline Clinical Characteristics and Complement Biomarkers of Patients with C3 Glomerulopathy Enrolled in Two Phase 2 Studies Investigating the Factor D Inhibitor Danicopan. Am J Nephrol. 2022; 53(10):675-686.
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Thurman JM, Harrison RA. The susceptibility of the kidney to alternative pathway activation-A hypothesis. Immunol Rev. 2023 01; 313(1):327-338.
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Fahnoe KC, Liu F, Morgan JG, Ryan ST, Storek M, Stark EG, Taylor FR, Holers VM, Thurman JM, Wawersik S, Kalled SL, Violette SM. Development and Optimization of Bifunctional Fusion Proteins to Locally Modulate Complement Activation in Diseased Tissue. Front Immunol. 2022; 13:869725.
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Schriek P, Ching AC, Moily NS, Moffat J, Beattie L, Steiner TM, Hosking LM, Thurman JM, Holers VM, Ishido S, Lahoud MH, Caminschi I, Heath WR, Mintern JD, Villadangos JA. Marginal zone B cells acquire dendritic cell functions by trogocytosis. Science. 2022 02 11; 375(6581):eabf7470.
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Li Y, Wang G, Griffin L, Banda NK, Saba LM, Groman EV, Scheinman R, Moghimi SM, Simberg D. Complement opsonization of nanoparticles: Differences between humans and preclinical species. J Control Release. 2021 10 10; 338:548-556.
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Wahid AA, Dunphy RW, Macpherson A, Gibson BG, Kulik L, Whale K, Back C, Hallam TM, Alkhawaja B, Martin RL, Meschede I, Laabei M, Lawson ADG, Holers VM, Watts AG, Crennell SJ, Harris CL, Marchbank KJ, van den Elsen JMH. Insights Into the Structure-Function Relationships of Dimeric C3d Fragments. Front Immunol. 2021; 12:714055.
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Cohen CC, Castillo-Leon E, Farris AB, Caltharp SA, Cleeton RL, Sinclair EM, Shevell DE, Karsdal MA, Nielsen MJF, Leeming DJ, Vos MB. PRO-C3, a Serological Marker of Fibrosis, During Childhood and Correlations With Fibrosis in Pediatric NAFLD. Hepatol Commun. 2021 11; 5(11):1860-1872.
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Spittler AP, Afzali MF, Martinez RB, Culver LA, Leavell SE, Timkovich AE, Sanford JL, Story MR, Santangelo KS. Evaluation of electroacupuncture for symptom modification in a rodent model of spontaneous osteoarthritis. Acupunct Med. 2021 Dec; 39(6):700-707.
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