 JNK Mitogen-Activated Protein Kinases
"JNK Mitogen-Activated Protein Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.
| Descriptor ID |
D048031
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| MeSH Number(s) |
D08.811.913.696.620.682.700.567.374 D12.644.360.450.340 D12.776.476.450.340
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| Concept/Terms |
JNK Mitogen-Activated Protein Kinases- JNK Mitogen-Activated Protein Kinases
- JNK Mitogen Activated Protein Kinases
- jun-NH2-Terminal Kinase
- jun NH2 Terminal Kinase
- jun-NH2-Terminal Kinases
- jun NH2 Terminal Kinases
- c-jun Amino-Terminal Kinase
- Amino-Terminal Kinase, c-jun
- c jun Amino Terminal Kinase
- c-jun N-Terminal Kinase
- N-Terminal Kinase, c-jun
- c jun N Terminal Kinase
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Below are MeSH descriptors whose meaning is more general than "JNK Mitogen-Activated Protein Kinases".
Below are MeSH descriptors whose meaning is more specific than "JNK Mitogen-Activated Protein Kinases".
This graph shows the total number of publications written about "JNK Mitogen-Activated Protein Kinases" by people in this website by year, and whether "JNK Mitogen-Activated Protein Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 0 | 1 | 1 | | 1996 | 0 | 4 | 4 | | 1997 | 1 | 6 | 7 | | 1998 | 0 | 3 | 3 | | 1999 | 0 | 4 | 4 | | 2000 | 1 | 7 | 8 | | 2001 | 0 | 11 | 11 | | 2002 | 2 | 8 | 10 | | 2003 | 0 | 8 | 8 | | 2004 | 5 | 2 | 7 | | 2005 | 2 | 4 | 6 | | 2006 | 3 | 0 | 3 | | 2007 | 1 | 1 | 2 | | 2008 | 2 | 3 | 5 | | 2009 | 1 | 6 | 7 | | 2010 | 1 | 2 | 3 | | 2011 | 3 | 2 | 5 | | 2012 | 0 | 2 | 2 | | 2013 | 0 | 2 | 2 | | 2014 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2017 | 1 | 1 | 2 | | 2018 | 0 | 4 | 4 | | 2019 | 1 | 1 | 2 | | 2020 | 1 | 1 | 2 | | 2022 | 0 | 1 | 1 | | 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "JNK Mitogen-Activated Protein Kinases" by people in Profiles.
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Mattos WLLD, Khalil N, Spencer LG, Bonella F, Folz RJ, Rolf JD, Mogulkoc N, Lancaster LH, Jenkins RG, Lynch DA, Noble PW, Maher TM, Cottin V, Senger S, Horan GS, Greenberg S, Popmihajlov Z. Phase 2, Double-Blind, Placebo-controlled Trial of a c-Jun N-Terminal Kinase Inhibitor in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2024 Aug 15; 210(4):435-443.
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Popmihajlov Z, Sutherland DJ, Horan GS, Ghosh A, Lynch DA, Noble PW, Richeldi L, Reiss TF, Greenberg S. CC-90001, a c-Jun N-terminal kinase (JNK) inhibitor, in patients with pulmonary fibrosis: design of a phase 2, randomised, placebo-controlled trial. BMJ Open Respir Res. 2022 Jan; 9(1).
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Akakpo JY, Ramachandran A, Orhan H, Curry SC, Rumack BH, Jaeschke H. 4-methylpyrazole protects against acetaminophen-induced acute kidney injury. Toxicol Appl Pharmacol. 2020 12 15; 409:115317.
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Strassheim D, Karoor V, Nijmeh H, Weston P, Lapel M, Schaack J, Sullivan T, Dempsey EC, Stenmark KR, Gerasimovskaya E. c-Jun, Foxo3a, and c-Myc Transcription Factors are Key Regulators of ATP-Mediated Angiogenic Responses in Pulmonary Artery Vasa Vasorum Endothelial Cells. Cells. 2020 02 11; 9(2).
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Goswami DG, Kant R, Ammar DA, Agarwal C, Gomez J, Agarwal R, Saba LM, Fritz KS, Tewari-Singh N. Toxic consequences and oxidative protein carbonylation from chloropicrin exposure in human corneal epithelial cells. Toxicol Lett. 2020 Apr 01; 322:1-11.
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Akakpo JY, Ramachandran A, Duan L, Schaich MA, Jaeschke MW, Freudenthal BD, Ding WX, Rumack BH, Jaeschke H. Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun n-Terminal Kinase. Toxicol Sci. 2019 07 01; 170(1):57-68.
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Verghese S, Su TT. Ionizing radiation induces stem cell-like properties in a caspase-dependent manner in Drosophila. PLoS Genet. 2018 11; 14(11):e1007659.
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Gibson ES, Woolfrey KM, Li H, Hogan PG, Nemenoff RA, Heasley LE, Dell'Acqua ML. Subcellular Localization and Activity of the Mitogen-Activated Protein Kinase Kinase 7 (MKK7) ? Isoform are Regulated through Binding to the Phosphatase Calcineurin. Mol Pharmacol. 2019 01; 95(1):20-32.
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Levi NJ, Wilson CW, Redweik GAJ, Gray NW, Grzybowski CW, Lenkey JA, Moseman AW, Bertsch AD, Dao N, Walsh HE. Obesity-related cellular stressors regulate gonadotropin releasing hormone gene expression via c-Fos/AP-1. Mol Cell Endocrinol. 2018 12 15; 478:97-105.
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Akakpo JY, Ramachandran A, Kandel SE, Ni HM, Kumer SC, Rumack BH, Jaeschke H. 4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes. Hum Exp Toxicol. 2018 Dec; 37(12):1310-1322.
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