 Interleukin-1 Receptor-Associated Kinases
"Interleukin-1 Receptor-Associated Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of intracellular signaling kinases that were identified by their ability to signal from the activated INTERLEUKIN-1 RECEPTORS. Signaling from these kinases involves their interaction with SIGNAL TRANSDUCING ADAPTOR PROTEINS such as MYELOID DIFFERENTIATION FACTOR 88 and TNF RECEPTOR-ASSOCIATED FACTOR 6.
| Descriptor ID |
D053592
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| MeSH Number(s) |
D08.811.913.696.620.682.700.526 D12.644.360.370 D12.776.476.384
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| Concept/Terms |
Interleukin-1 Receptor-Associated Kinases- Interleukin-1 Receptor-Associated Kinases
- Interleukin 1 Receptor Associated Kinases
- Kinases, Interleukin-1 Receptor-Associated
- Receptor-Associated Kinases, Interleukin-1
- IRAK Kinases
- Kinases, IRAK
- IL-1 Receptor-Associated Kinase
- IL 1 Receptor Associated Kinase
- Kinase, IL-1 Receptor-Associated
- Receptor-Associated Kinase, IL-1
- Interleukin-1 Receptor-Associated Kinase
- Interleukin 1 Receptor Associated Kinase
- Kinase, Interleukin-1 Receptor-Associated
- Receptor-Associated Kinase, Interleukin-1
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Below are MeSH descriptors whose meaning is more general than "Interleukin-1 Receptor-Associated Kinases".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-1 Receptor-Associated Kinases".
This graph shows the total number of publications written about "Interleukin-1 Receptor-Associated Kinases" by people in this website by year, and whether "Interleukin-1 Receptor-Associated Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2009 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 0 | 1 | 1 | | 2018 | 0 | 3 | 3 | | 2019 | 1 | 0 | 1 | | 2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "Interleukin-1 Receptor-Associated Kinases" by people in Profiles.
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Wang Q, Notay K, Downey GP, McCulloch CA. The Leucine-Rich Repeat Region of CARMIL1 Regulates IL-1-Mediated ERK Activation, MMP Expression, and Collagen Degradation. Cell Rep. 2020 06 30; 31(13):107781.
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Geng D, Ciavattone N, Lasola JJ, Shrestha R, Sanchez A, Guo J, Vlk A, Younis R, Wang L, Brown AJ, Zhang Y, Velasco-Gonzalez C, Tan AC, Davila E. Induction of IRAK-M in melanoma induces caspase-3 dependent apoptosis by reducing TRAF6 and calpastatin levels. Commun Biol. 2020 06 12; 3(1):306.
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Dakhama A, Al Mubarak R, Pavelka N, Voelker D, Seibold M, Ledford JG, Kraft M, Li L, Chu HW. Tollip Inhibits ST2 Signaling in Airway Epithelial Cells Exposed to Type 2 Cytokines and Rhinovirus. J Innate Immun. 2020; 12(1):103-115.
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Berman R, Downey GP, Dakhama A, Day BJ, Chu HW. Afghanistan Particulate Matter Enhances Pro-Inflammatory Responses in IL-13-Exposed Human Airway Epithelium via TLR2 Signaling. Toxicol Sci. 2018 Dec 01; 166(2):345-353.
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Ito Y, Schaefer N, Sanchez A, Francisco D, Alam R, Martin RJ, Ledford JG, Stevenson C, Jiang D, Li L, Kraft M, Chu HW. Toll-Interacting Protein, Tollip, Inhibits IL-13-Mediated Pulmonary Eosinophilic Inflammation in Mice. J Innate Immun. 2018; 10(2):106-118.
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Wang Q, Delcorde J, Tang T, Downey GP, McCulloch CA. Regulation of IL-1 signaling through control of focal adhesion assembly. FASEB J. 2018 06; 32(6):3119-3132.
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Liang K, Volk AG, Haug JS, Marshall SA, Woodfin AR, Bartom ET, Gilmore JM, Florens L, Washburn MP, Sullivan KD, Espinosa JM, Cannova J, Zhang J, Smith ER, Crispino JD, Shilatifard A. Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia. Cell. 2017 Jan 12; 168(1-2):59-72.e13.
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Jiang D, Matsuda J, Berman R, Schaefer N, Stevenson C, Gross J, Zhang B, Sanchez A, Li L, Chu HW. A novel mouse model of conditional IRAK-M deficiency in myeloid cells: application in lung Pseudomonas aeruginosa infection. Innate Immun. 2017 02; 23(2):206-215.
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Ryu S, Johnson A, Park Y, Kim B, Norris D, Armstrong CA, Song PI. The Alpha-Melanocyte-Stimulating Hormone Suppresses TLR2-Mediated Functional Responses through IRAK-M in Normal Human Keratinocytes. PLoS One. 2015; 10(8):e0136887.
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Li Z, Younger K, Gartenhaus R, Joseph AM, Hu F, Baer MR, Brown P, Davila E. Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies. J Clin Invest. 2015 Mar 02; 125(3):1081-97.
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