 Toll-Like Receptor 2
"Toll-Like Receptor 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pattern recognition receptor that forms heterodimers with other TOLL-LIKE RECEPTORS. It interacts with multiple ligands including PEPTIDOGLYCAN, bacterial LIPOPROTEINS, lipoarabinomannan, and a variety of PORINS.
| Descriptor ID |
D051195
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| MeSH Number(s) |
D12.776.543.750.705.910.500.200
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Toll-Like Receptor 2".
Below are MeSH descriptors whose meaning is more specific than "Toll-Like Receptor 2".
This graph shows the total number of publications written about "Toll-Like Receptor 2" by people in this website by year, and whether "Toll-Like Receptor 2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 | | 2002 | 0 | 2 | 2 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 6 | 6 | | 2005 | 0 | 5 | 5 | | 2006 | 1 | 3 | 4 | | 2007 | 4 | 2 | 6 | | 2008 | 1 | 3 | 4 | | 2009 | 3 | 2 | 5 | | 2010 | 5 | 2 | 7 | | 2011 | 1 | 3 | 4 | | 2012 | 3 | 2 | 5 | | 2013 | 3 | 2 | 5 | | 2014 | 5 | 1 | 6 | | 2015 | 2 | 3 | 5 | | 2016 | 0 | 2 | 2 | | 2017 | 0 | 1 | 1 | | 2018 | 0 | 1 | 1 | | 2020 | 2 | 2 | 4 | | 2021 | 1 | 1 | 2 | | 2022 | 2 | 1 | 3 |
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Below are the most recent publications written about "Toll-Like Receptor 2" by people in Profiles.
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Horn KJ, Schopper MA, Drigot ZG, Clark SE. Airway Prevotella promote TLR2-dependent neutrophil activation and rapid clearance of Streptococcus pneumoniae from the lung. Nat Commun. 2022 06 09; 13(1):3321.
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Zhai Y, Ao L, Yao Q, The E, Fullerton DA, Meng X. Elevated Expression of TLR2 in Aging Hearts Exacerbates Cardiac Inflammatory Response and Adverse Remodeling Following Ischemia and Reperfusion Injury. Front Immunol. 2022; 13:891570.
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Bansal A, Mostafa MM, Kooi C, Sasse SK, Michi AN, Shah SV, Leigh R, Gerber AN, Newton R. Interplay between nuclear factor-?B, p38 MAPK, and glucocorticoid receptor signaling synergistically induces functional TLR2 in lung epithelial cells. J Biol Chem. 2022 04; 298(4):101747.
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Hook JS, Patel PA, O'Malley A, Xie L, Kavanaugh JS, Horswill AR, Moreland JG. Lipoproteins from Staphylococcus aureus Drive Neutrophil Extracellular Trap Formation in a TLR2/1- and PAD-Dependent Manner. J Immunol. 2021 08 01; 207(3):966-973.
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Kwilasz AJ, Green Fulgham SM, Duran-Malle JC, Schrama AEW, Mitten EH, Todd LS, Patel HP, Larson TA, Clements MA, Harris KM, Litwiler ST, Harvey LO, Maier SF, Chavez RA, Rice KC, Van Dam AM, Watkins LR. Toll-like receptor 2 and 4 antagonism for the treatment of experimental autoimmune encephalomyelitis (EAE)-related pain. Brain Behav Immun. 2021 03; 93:80-95.
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Zhang P, The E, Nedumaran B, Ao L, Jarrett MJ, Xu D, Fullerton DA, Meng X. Monocytes enhance the inflammatory response to TLR2 stimulation in aortic valve interstitial cells through paracrine up-regulation of TLR2 level. Int J Biol Sci. 2020; 16(15):3062-3074.
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Gergen AK, Kohtz PD, Halpern AL, Li A, Meng X, Reece TB, Fullerton DA, Weyant MJ. Activation of Toll-Like Receptor 2 Promotes Proliferation of Human Lung Adenocarcinoma Cells. Anticancer Res. 2020 Oct; 40(10):5361-5369.
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Kwilasz AJ, Todd LS, Duran-Malle JC, Schrama AEW, Mitten EH, Larson TA, Clements MA, Harris KM, Litwiler ST, Wang X, Van Dam AM, Maier SF, Rice KC, Watkins LR, Barrientos RM. Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits are prevented with the non-opioid TLR2/TLR4 antagonist (+)-naltrexone. Behav Brain Res. 2021 01 01; 396:112896.
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The E, Yao Q, Zhang P, Zhai Y, Ao L, Fullerton DA, Meng X. Mechanistic Roles of Matrilin-2 and Klotho in Modulating the Inflammatory Activity of Human Aortic Valve Cells. Cells. 2020 02 07; 9(2).
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Berman R, Downey GP, Dakhama A, Day BJ, Chu HW. Afghanistan Particulate Matter Enhances Pro-Inflammatory Responses in IL-13-Exposed Human Airway Epithelium via TLR2 Signaling. Toxicol Sci. 2018 Dec 01; 166(2):345-353.
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