 Protein Phosphatase 2
"Protein Phosphatase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phosphoprotein phosphatase subtype that is comprised of a catalytic subunit and two different regulatory subunits. At least two genes encode isoforms of the protein phosphatase catalytic subunit, while several isoforms of regulatory subunits exist due to the presence of multiple genes and the alternative splicing of their mRNAs. Protein phosphatase 2 acts on a broad variety of cellular proteins and may play a role as a regulator of intracellular signaling processes.
| Descriptor ID |
D054648
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| MeSH Number(s) |
D08.811.277.352.650.625.706 D12.644.360.583 D12.776.476.561
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| Concept/Terms |
Protein Phosphatase 2, Catalytic Subunit, alpha Isoform- Protein Phosphatase 2, Catalytic Subunit, alpha Isoform
- PPP2CA Phosphatase
- Phosphatase, PPP2CA
- Protein Phosphatase 2A, Catalytic Subunit, alpha Isoform
- Serine-Threonine-Protein Phosphatase 2A Catalytic Subunit alpha Isoform
- Serine Threonine Protein Phosphatase 2A Catalytic Subunit alpha Isoform
Protein Phosphatase 2, Catalytic Subunit, beta Isoform- Protein Phosphatase 2, Catalytic Subunit, beta Isoform
- Protein Phosphatase 2A, Catalytic Subunit, beta Isoform
- PPP2CB Phosphatase
- Phosphatase, PPP2CB
- Serine Threonine Protein Phosphatase 2A Catalytic Subunit beta Isoform
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Below are MeSH descriptors whose meaning is more general than "Protein Phosphatase 2".
Below are MeSH descriptors whose meaning is more specific than "Protein Phosphatase 2".
This graph shows the total number of publications written about "Protein Phosphatase 2" by people in this website by year, and whether "Protein Phosphatase 2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 1996 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2006 | 0 | 3 | 3 | | 2007 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2013 | 0 | 2 | 2 | | 2014 | 1 | 0 | 1 | | 2017 | 2 | 0 | 2 | | 2018 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 | | 2020 | 1 | 1 | 2 | | 2021 | 1 | 0 | 1 | | 2024 | 1 | 0 | 1 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Phosphatase 2" by people in Profiles.
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Bernard PB, Castano AM, Buonarati OR, Camp CR, Hell JW, Benke TA. Early life seizures chronically disrupt L-type voltage gated calcium channel regulation of mGluR mediated long term depression via interactions with protein phosphatase 2A. Neurobiol Dis. 2025 Jun 01; 209:106884.
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Alderman C, Anderson R, Zhang L, Hughes CJ, Li X, Ebmeier C, Wagley ME, Ahn NG, Ford HL, Zhao R. Biochemical characterization of the Eya and PP2A-B55a interaction. J Biol Chem. 2024 07; 300(7):107408.
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Davuluri G, Welch N, Sekar J, Gangadhariah M, Alsabbagh Alchirazi K, Mohan ML, Kumar A, Kant S, Thapaliya S, Stine M, McMullen MR, McCullough RL, Stark GR, Nagy LE, Naga Prasad SV, Dasarathy S. Activated Protein Phosphatase 2A Disrupts Nutrient Sensing Balance Between Mechanistic Target of Rapamycin Complex 1 and Adenosine Monophosphate-Activated Protein Kinase, Causing Sarcopenia in Alcohol-Associated Liver Disease. Hepatology. 2021 05; 73(5):1892-1908.
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Goto RN, Sobral LM, Stringhetta-Padovani K, Garcia CB, da Silva G, Vitek MP, Leopoldino AM. Synergic effect of OP449 and FTY720 on oral squamous cell carcinoma. Eur J Pharmacol. 2020 Sep 05; 882:173268.
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Leonard D, Huang W, Izadmehr S, O'Connor CM, Wiredja DD, Wang Z, Zaware N, Chen Y, Schlatzer DM, Kiselar J, Vasireddi N, Sch?chner S, Perl AL, Galsky MD, Xu W, Brautigan DL, Ogris E, Taylor DJ, Narla G. Selective PP2A Enhancement through Biased Heterotrimer Stabilization. Cell. 2020 04 30; 181(3):688-701.e16.
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O'Connor CM, Leonard D, Wiredja D, Avelar RA, Wang Z, Schlatzer D, Bryson B, Tokala E, Taylor SE, Upadhyay A, Sangodkar J, Gingras AC, Westermarck J, Xu W, DiFeo A, Brautigan DL, Haider S, Jackson M, Narla G. Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors. Oncogene. 2020 01; 39(3):703-717.
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Zhang L, Zhou H, Li X, Vartuli RL, Rowse M, Xing Y, Rudra P, Ghosh D, Zhao R, Ford HL. Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression. Nat Commun. 2018 03 13; 9(1):1047.
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Guo F, Wlodarchak N, Menden P, Xing Y. Purification of Target Proteins from Native Tissues: CCT Complex from Bovine Testes and PP2Ac from Porcine Brains. Methods Mol Biol. 2018; 1788:73-88.
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Wiredja DD, Ayati M, Mazhar S, Sangodkar J, Maxwell S, Schlatzer D, Narla G, Koyut?rk M, Chance MR. Phosphoproteomics Profiling of Nonsmall Cell Lung Cancer Cells Treated with a Novel Phosphatase Activator. Proteomics. 2017 Nov; 17(22).
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Sangodkar J, Perl A, Tohme R, Kiselar J, Kastrinsky DB, Zaware N, Izadmehr S, Mazhar S, Wiredja DD, O'Connor CM, Hoon D, Dhawan NS, Schlatzer D, Yao S, Leonard D, Borczuk AC, Gokulrangan G, Wang L, Svenson E, Farrington CC, Yuan E, Avelar RA, Stachnik A, Smith B, Gidwani V, Giannini HM, McQuaid D, McClinch K, Wang Z, Levine AC, Sears RC, Chen EY, Duan Q, Datt M, Haider S, Ma'ayan A, DiFeo A, Sharma N, Galsky MD, Brautigan DL, Ioannou YA, Xu W, Chance MR, Ohlmeyer M, Narla G. Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth. J Clin Invest. 2017 Jun 01; 127(6):2081-2090.
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