 Protein Phosphatase 2
"Protein Phosphatase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phosphoprotein phosphatase subtype that is comprised of a catalytic subunit and two different regulatory subunits. At least two genes encode isoforms of the protein phosphatase catalytic subunit, while several isoforms of regulatory subunits exist due to the presence of multiple genes and the alternative splicing of their mRNAs. Protein phosphatase 2 acts on a broad variety of cellular proteins and may play a role as a regulator of intracellular signaling processes.
| Descriptor ID |
D054648
|
| MeSH Number(s) |
D08.811.277.352.650.625.706 D12.644.360.583 D12.776.476.561
|
| Concept/Terms |
Protein Phosphatase 2, Catalytic Subunit, alpha Isoform- Protein Phosphatase 2, Catalytic Subunit, alpha Isoform
- PPP2CA Phosphatase
- Phosphatase, PPP2CA
- Protein Phosphatase 2A, Catalytic Subunit, alpha Isoform
- Serine-Threonine-Protein Phosphatase 2A Catalytic Subunit alpha Isoform
- Serine Threonine Protein Phosphatase 2A Catalytic Subunit alpha Isoform
Protein Phosphatase 2, Catalytic Subunit, beta Isoform- Protein Phosphatase 2, Catalytic Subunit, beta Isoform
- Protein Phosphatase 2A, Catalytic Subunit, beta Isoform
- PPP2CB Phosphatase
- Phosphatase, PPP2CB
- Serine Threonine Protein Phosphatase 2A Catalytic Subunit beta Isoform
|
Below are MeSH descriptors whose meaning is more general than "Protein Phosphatase 2".
Below are MeSH descriptors whose meaning is more specific than "Protein Phosphatase 2".
This graph shows the total number of publications written about "Protein Phosphatase 2" by people in this website by year, and whether "Protein Phosphatase 2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 0 | 1 | 1 | | 1993 | 0 | 2 | 2 | | 1994 | 0 | 1 | 1 | | 1995 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 3 | 3 | | 2007 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 2 | 3 | | 2013 | 0 | 2 | 2 | | 2014 | 2 | 0 | 2 | | 2018 | 1 | 0 | 1 | | 2020 | 0 | 1 | 1 | | 2021 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Protein Phosphatase 2" by people in Profiles.
-
Davuluri G, Welch N, Sekar J, Gangadhariah M, Alsabbagh Alchirazi K, Mohan ML, Kumar A, Kant S, Thapaliya S, Stine M, McMullen MR, McCullough RL, Stark GR, Nagy LE, Naga Prasad SV, Dasarathy S. Activated Protein Phosphatase 2A Disrupts Nutrient Sensing Balance Between Mechanistic Target of Rapamycin Complex 1 and Adenosine Monophosphate-Activated Protein Kinase, Causing Sarcopenia in Alcohol-Associated Liver Disease. Hepatology. 2021 05; 73(5):1892-1908.
-
Goto RN, Sobral LM, Stringhetta-Padovani K, Garcia CB, da Silva G, Vitek MP, Leopoldino AM. Synergic effect of OP449 and FTY720 on oral squamous cell carcinoma. Eur J Pharmacol. 2020 Sep 05; 882:173268.
-
Zhang L, Zhou H, Li X, Vartuli RL, Rowse M, Xing Y, Rudra P, Ghosh D, Zhao R, Ford HL. Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression. Nat Commun. 2018 03 13; 9(1):1047.
-
Guo F, Wlodarchak N, Menden P, Xing Y. Purification of Target Proteins from Native Tissues: CCT Complex from Bovine Testes and PP2Ac from Porcine Brains. Methods Mol Biol. 2018; 1788:73-88.
-
Wlodarchak N, Xing Y. PP2A as a master regulator of the cell cycle. Crit Rev Biochem Mol Biol. 2016 May-Jun; 51(3):162-84.
-
Chen W, Xiao H, Rizzo AN, Zhang W, Mai Y, Ye M. Endothelial nitric oxide synthase dimerization is regulated by heat shock protein 90 rather than by phosphorylation. PLoS One. 2014; 9(8):e105479.
-
Stanevich V, Zheng A, Guo F, Jiang L, Wlodarchak N, Xing Y. Mechanisms of the scaffold subunit in facilitating protein phosphatase 2A methylation. PLoS One. 2014; 9(1):e86955.
-
Honarpour N, Rose CM, Brumbaugh J, Anderson J, Graham RL, Sweredoski MJ, Hess S, Coon JJ, Deshaies RJ. F-box protein FBXL16 binds PP2A-B55a and regulates differentiation of embryonic stem cells along the FLK1+ lineage. Mol Cell Proteomics. 2014 Mar; 13(3):780-91.
-
Yamamoto TM, Wang L, Fisher LA, Eckerdt FD, Peng A. Regulation of Greatwall kinase by protein stabilization and nuclear localization. Cell Cycle. 2014; 13(22):3565-75.
-
Guo F, Stanevich V, Wlodarchak N, Sengupta R, Jiang L, Satyshur KA, Xing Y. Structural basis of PP2A activation by PTPA, an ATP-dependent activation chaperone. Cell Res. 2014 Feb; 24(2):190-203.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|