 Protein Phosphatase 2
"Protein Phosphatase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phosphoprotein phosphatase subtype that is comprised of a catalytic subunit and two different regulatory subunits. At least two genes encode isoforms of the protein phosphatase catalytic subunit, while several isoforms of regulatory subunits exist due to the presence of multiple genes and the alternative splicing of their mRNAs. Protein phosphatase 2 acts on a broad variety of cellular proteins and may play a role as a regulator of intracellular signaling processes.
| Descriptor ID |
D054648
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| MeSH Number(s) |
D08.811.277.352.650.625.706 D12.644.360.583 D12.776.476.561
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| Concept/Terms |
Protein Phosphatase 2, Catalytic Subunit, alpha Isoform- Protein Phosphatase 2, Catalytic Subunit, alpha Isoform
- PPP2CA Phosphatase
- Phosphatase, PPP2CA
- Protein Phosphatase 2A, Catalytic Subunit, alpha Isoform
- Serine-Threonine-Protein Phosphatase 2A Catalytic Subunit alpha Isoform
- Serine Threonine Protein Phosphatase 2A Catalytic Subunit alpha Isoform
Protein Phosphatase 2, Catalytic Subunit, beta Isoform- Protein Phosphatase 2, Catalytic Subunit, beta Isoform
- Protein Phosphatase 2A, Catalytic Subunit, beta Isoform
- PPP2CB Phosphatase
- Phosphatase, PPP2CB
- Serine Threonine Protein Phosphatase 2A Catalytic Subunit beta Isoform
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Below are MeSH descriptors whose meaning is more general than "Protein Phosphatase 2".
Below are MeSH descriptors whose meaning is more specific than "Protein Phosphatase 2".
This graph shows the total number of publications written about "Protein Phosphatase 2" by people in this website by year, and whether "Protein Phosphatase 2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 0 | 1 | 1 | | 1993 | 0 | 2 | 2 | | 1994 | 0 | 1 | 1 | | 1995 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2006 | 0 | 3 | 3 | | 2007 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 2 | 3 | | 2013 | 0 | 2 | 2 | | 2014 | 2 | 1 | 3 | | 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Phosphatase 2" by people in Profiles.
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Zhang L, Zhou H, Li X, Vartuli RL, Rowse M, Xing Y, Rudra P, Ghosh D, Zhao R, Ford HL. Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression. Nat Commun. 2018 03 13; 9(1):1047.
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Chen W, Xiao H, Rizzo AN, Zhang W, Mai Y, Ye M. Endothelial nitric oxide synthase dimerization is regulated by heat shock protein 90 rather than by phosphorylation. PLoS One. 2014; 9(8):e105479.
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Honarpour N, Rose CM, Brumbaugh J, Anderson J, Graham RL, Sweredoski MJ, Hess S, Coon JJ, Deshaies RJ. F-box protein FBXL16 binds PP2A-B55a and regulates differentiation of embryonic stem cells along the FLK1+ lineage. Mol Cell Proteomics. 2014 Mar; 13(3):780-91.
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Yamamoto TM, Wang L, Fisher LA, Eckerdt FD, Peng A. Regulation of Greatwall kinase by protein stabilization and nuclear localization. . 2014; 13(22):3565-75.
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Bernard PB, Castano AM, O'Leary H, Simpson K, Browning MD, Benke TA. Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures. Neurobiol Dis. 2013 Nov; 59:1-17.
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Walker LA, Fullerton DA, Buttrick PM. Contractile protein phosphorylation predicts human heart disease phenotypes. . 2013 Jun 15; 304(12):H1644-50.
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Zgheib C, Zouein FA, Chidiac R, Kurdi M, Booz GW. Calyculin A reveals serine/threonine phosphatase protein phosphatase 1 as a regulatory nodal point in canonical signal transducer and activator of transcription 3 signaling of human microvascular endothelial cells. J Interferon Cytokine Res. 2012 Feb; 32(2):87-94.
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Tan W, Sunahori K, Zhao J, Deng Y, Kaufman KM, Kelly JA, Langefeld CD, Williams AH, Comeau ME, Ziegler JT, Marion MC, Bae SC, Lee JH, Lee JS, Chang DM, Song YW, Yu CY, Kimberly RP, Edberg JC, Brown EE, Petri MA, Ramsey-Goldman R, Vilá LM, Reveille JD, Alarcón-Riquelme ME, Harley JB, Boackle SA, Stevens AM, Scofield RH, Merrill JT, Freedman BI, Anaya JM, Criswell LA, Jacob CO, Vyse TJ, Niewold TB, Gaffney PM, Moser KL, Gilkeson GS, Kamen DL, James JA, Grossman JM, Hahn BH, Tsokos GC, Tsao BP, Alarcón GS. Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups. Arthritis Rheum. 2011 Sep; 63(9):2755-63.
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Yamamoto TM, Blake-Hodek K, Williams BC, Lewellyn AL, Goldberg ML, Maller JL. Regulation of Greatwall kinase during Xenopus oocyte maturation. Mol Biol Cell. 2011 Jul 01; 22(13):2157-64.
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Purev E, Soprano DR, Soprano KJ. PP2A interaction with Rb2/p130 mediates translocation of Rb2/p130 into the nucleus in all-trans retinoic acid-treated ovarian carcinoma cells. J Cell Physiol. 2011 Apr; 226(4):1027-34.
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