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Rui Zhao

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BioChem&Molecular Genetics
Phone303/724-3269
    Other Positions
    TitleAssoc Chair
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-BioChem&Molecular Genetics


    Collapse Research 
    Collapse research activities and funding
    R41CA291231     (FORD, HEIDE L.)Aug 15, 2024 - Jul 31, 2025
    NIH
    Preclinical Studies to Develop an Eya2 Tyr Phosphatase Inhibitor as a Novel Medulloblastoma Therapeutic
    Role: Co-Principal Investigator
    R35GM145289     (ZHAO, RUI)Jun 1, 2022 - May 31, 2027
    NIH
    The molecular mechanism of pre-mRNA splicing
    Role: Principal Investigator
    R01GM130673     (ZHAO, RUI)Sep 1, 2019 - Jul 31, 2023
    NIH
    Structure and function of spliceosome
    Role: Principal Investigator
    R01GM126157     (ZHAO, RUI)Aug 1, 2018 - Jun 30, 2022
    NIH
    Understanding the structure and function of U1 snRNP
    Role: Principal Investigator
    R01CA221282     (FORD, HEIDE L.)Aug 1, 2017 - Jul 31, 2022
    NIH
    Role of Eya3 in regulating the immune microenvironment to promote breast tumor progression
    Role: Co-Principal Investigator
    R01GM114178     (ZHAO, RUI)Apr 1, 2015 - Mar 31, 2020
    NIH
    Structure and function of U5 snRNP
    Role: Principal Investigator
    R21CA185752     (FORD, HEIDE L.)Dec 18, 2014 - Nov 30, 2016
    NIH
    Developing cancer therapies through targeting the Six1/Eya transcriptional complex
    Role: Co-Principal Investigator
    R21NS085514     (ZHAO, RUI)Jul 1, 2014 - May 31, 2017
    NIH
    Spinal muscular atrophy therapy using recombinant SMN proteins
    Role: Principal Investigator
    R41CA180347     (FORD, HEIDE L.)Jul 17, 2013 - Mar 31, 2015
    NIH
    The anti-tumorigenic and anti-metastatic potential of Eya phosphatase inhibitors
    Role: Co-Principal Investigator
    R03DA033982     (ZHAO, RUI)Feb 1, 2012 - Jan 31, 2014
    NIH
    Identify Inhibitors of the Transcriptional Co-Repressor CtBP Using HTS for Cancer
    Role: Principal Investigator
    R03DA033174     (ZHAO, RUI)Jul 15, 2011 - Jun 30, 2014
    NIH
    Identify inhibitors of the Six1/Eya interaction using high throughput screening
    Role: Principal Investigator
    R03DA030559     (ZHAO, RUI)Jun 1, 2010 - May 31, 2012
    NIH
    Identify inhibitors of the Eya phosphatase activity using high throughput screeni
    Role: Principal Investigator
    R01GM080334     (ZHAO, RUI)Sep 1, 2008 - Aug 31, 2014
    NIH
    Understanding the structure and function of splicing factor Prp8
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wang L, Chang Y, Wu S, Zhao RR, Chen W. Physics-aware differentiable design of magnetically actuated kirigami for shape morphing. Nat Commun. 2023 Dec 21; 14(1):8516. PMID: 38129420.
      View in: PubMed
    2. Leanza S, Wu S, Sun X, Qi HJ, Zhao RR. Active Materials for Functional Origami. Adv Mater. 2024 Mar; 36(9):e2302066. PMID: 37120795.
      View in: PubMed
    3. Maurin V, Chang Y, Ze Q, Leanza S, Wang J, Zhao RR. Liquid Crystal Elastomer-Liquid Metal Composite: Ultrafast, Untethered, and Programmable Actuation by Induction Heating. Adv Mater. 2024 Aug; 36(34):e2302765. PMID: 37656872.
      View in: PubMed
    4. Sim J, Wu S, Dai J, Zhao RR. Magneto-Mechanical Bilayer Metamaterial with Global Area-Preserving Density Tunability for Acoustic Wave Regulation. Adv Mater. 2023 Sep; 35(35):e2303541. PMID: 37335806.
      View in: PubMed
    5. Lee E, Redzic JS, Saviola AJ, Li X, Ebmeier CC, Kutateladze TG, Hansen KC, Zhao R, Ahn N, Sluchanko NN, Eisenmesser E. Molecular insight into the specific interactions of the SARS-Coronavirus-2 nucleocapsid with RNA and host protein. Protein Sci. 2023 04; 32(4):e4603. PMID: 36807437.
      View in: PubMed
    6. Espinosa S, De Bortoli F, Li X, Rossi J, Wagley ME, Lo HG, Taliaferro JM, Zhao R. Human PRPF39 is an alternative splicing factor recruiting U1 snRNP to weak 5' splice sites. RNA. 2022 Oct 31. PMID: 36316087.
      View in: PubMed
    7. Peng X, Wu S, Sun X, Yue L, Montgomery SM, Demoly F, Zhou K, Zhao RR, Qi HJ. 4D Printing of Freestanding Liquid Crystal Elastomers via Hybrid Additive Manufacturing. Adv Mater. 2022 Sep; 34(39):e2204890. PMID: 35962737.
      View in: PubMed
    8. Ma C, Chang Y, Wu S, Zhao RR. Deep Learning-Accelerated Designs of Tunable Magneto-Mechanical Metamaterials. ACS Appl Mater Interfaces. 2022 Jul 14. PMID: 35833606.
      View in: PubMed
    9. Ze Q, Wu S, Dai J, Leanza S, Ikeda G, Yang PC, Iaccarino G, Zhao RR. Spinning-enabled wireless amphibious origami millirobot. Nat Commun. 2022 06 14; 13(1):3118. PMID: 35701405.
      View in: PubMed
    10. Ze Q, Wu S, Nishikawa J, Dai J, Sun Y, Leanza S, Zemelka C, Novelino LS, Paulino GH, Zhao RR. Soft robotic origami crawler. Sci Adv. 2022 Apr; 8(13):eabm7834. PMID: 35353556.
      View in: PubMed
    11. Zhou H, Zhang L, Vartuli RL, Ford HL, Zhao R. Corrigendum to "The Eya phosphatase: Its unique role in cancer" [Int. J. Biochem. Cell Biol. 96 (2018) 165-170]. Int J Biochem Cell Biol. 2020 Oct; 127:105847. PMID: 32933829.
      View in: PubMed
    12. Eisenmesser EZ, Gottschlich A, Redzic JS, Paukovich N, Nix JC, Azam T, Zhang L, Zhao R, Kieft JS, The E, Meng X, Dinarello CA. Interleukin-37 monomer is the active form for reducing innate immunity. Proc Natl Acad Sci U S A. 2019 03 19; 116(12):5514-5522. PMID: 30819901.
      View in: PubMed
    13. Zhang L, Vielle A, Espinosa S, Zhao R. RNAs in the spliceosome: Insight from cryoEM structures. Wiley Interdiscip Rev RNA. 2019 05; 10(3):e1523. PMID: 30729694.
      View in: PubMed
    14. Zhang L, Zhou H, Li X, Vartuli RL, Rowse M, Xing Y, Rudra P, Ghosh D, Zhao R, Ford HL. Author Correction: Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression. Nat Commun. 2018 09 17; 9(1):3830. PMID: 30224630.
      View in: PubMed
    15. Blevins MA, Zhang C, Zhang L, Li H, Li X, Norris DA, Huang M, Zhao R. CPP-E1A fusion peptides inhibit CtBP-mediated transcriptional repression. Mol Oncol. 2018 08; 12(8):1358-1373. PMID: 29879296.
      View in: PubMed
    16. Vartuli RL, Zhou H, Zhang L, Powers RK, Klarquist J, Rudra P, Vincent MY, Ghosh D, Costello JC, Kedl RM, Slansky JE, Zhao R, Ford HL. Eya3 promotes breast tumor-associated immune suppression via threonine phosphatase-mediated PD-L1 upregulation. J Clin Invest. 2018 06 01; 128(6):2535-2550. PMID: 29757193.
      View in: PubMed
    17. Li X, Liu S, Jiang J, Zhang L, Espinosa S, Hill RC, Hansen KC, Zhou ZH, Zhao R. Author Correction: CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing. Nat Commun. 2018 04 11; 9(1):1495. PMID: 29643343.
      View in: PubMed
    18. Zhang L, Zhou H, Li X, Vartuli RL, Rowse M, Xing Y, Rudra P, Ghosh D, Zhao R, Ford HL. Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression. Nat Commun. 2018 03 13; 9(1):1047. PMID: 29535359.
      View in: PubMed
    19. Li X, Liu S, Jiang J, Zhang L, Espinosa S, Hill RC, Hansen KC, Zhou ZH, Zhao R. CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing. Nat Commun. 2017 10 19; 8(1):1035. PMID: 29051543.
      View in: PubMed
    20. Zhou H, Zhang L, Vartuli RL, Ford HL, Zhao R. The Eya phosphatase: Its unique role in cancer. Int J Biochem Cell Biol. 2018 03; 96:165-170. PMID: 28887153.
      View in: PubMed
    21. Blevins MA, Huang M, Zhao R. The Role of CtBP1 in Oncogenic Processes and Its Potential as a Therapeutic Target. Mol Cancer Ther. 2017 06; 16(6):981-990. PMID: 28576945.
      View in: PubMed
    22. Espinosa S, Zhang L, Li X, Zhao R. Understanding pre-mRNA splicing through crystallography. Methods. 2017 08 01; 125:55-62. PMID: 28506657.
      View in: PubMed
    23. Gavett BE, Zhao R, John SE, Bussell CA, Roberts JR, Yue C. Phishing suspiciousness in older and younger adults: The role of executive functioning. PLoS One. 2017; 12(2):e0171620. PMID: 28158316.
      View in: PubMed
    24. Zhang L, Li X, Hill RC, Qiu Y, Zhang W, Hansen KC, Zhao R. Brr2 plays a role in spliceosomal activation in addition to U4/U6 unwinding. Nucleic Acids Res. 2015 Mar 31; 43(6):3286-97. PMID: 25670679.
      View in: PubMed
    25. Blevins MA, Towers CG, Patrick AN, Zhao R, Ford HL. The SIX1-EYA transcriptional complex as a therapeutic target in cancer. Expert Opin Ther Targets. 2015 Feb; 19(2):213-25. PMID: 25555392.
      View in: PubMed
    26. Blevins MA, Kouznetsova J, Krueger AB, King R, Griner LM, Hu X, Southall N, Marugan JJ, Zhang Q, Ferrer M, Zhao R. Small Molecule, NSC95397, Inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression. J Biomol Screen. 2015 Jun; 20(5):663-72. PMID: 25477201.
      View in: PubMed
    27. Wang C, Chen Z, Hong X, Ning F, Liu H, Zang J, Yan X, Kemp J, Musselman CA, Kutateladze TG, Zhao R, Jiang C, Zhang G. The structural basis of urea-induced protein unfolding in ?-catenin. Acta Crystallogr D Biol Crystallogr. 2014 Nov; 70(Pt 11):2840-7. PMID: 25372676.
      View in: PubMed
    28. Garrey SM, Katolik A, Prekeris M, Li X, York K, Bernards S, Fields S, Zhao R, Damha MJ, Hesselberth JR. A homolog of lariat-debranching enzyme modulates turnover of branched RNA. RNA. 2014 Aug; 20(8):1337-48. PMID: 24919400.
      View in: PubMed
    29. Krueger AB, Drasin DJ, Lea WA, Patrick AN, Patnaik S, Backos DS, Matheson CJ, Hu X, Barnaeva E, Holliday MJ, Blevins MA, Robin TP, Eisenmesser EZ, Ferrer M, Simeonov A, Southall N, Reigan P, Marugan J, Ford HL, Zhao R. Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration. J Biol Chem. 2014 Jun 06; 289(23):16349-61. PMID: 24755226.
      View in: PubMed
    30. Zhang L, Li X, Zhao R. Structural analyses of the pre-mRNA splicing machinery. Protein Sci. 2013 Jun; 22(6):677-92. PMID: 23592432.
      View in: PubMed
    31. Han G, Bian L, Li F, Cotrim A, Wang D, Lu J, Deng Y, Bird G, Sowers A, Mitchell JB, Gutkind JS, Zhao R, Raben D, ten Dijke P, Refaeli Y, Zhang Q, Wang XJ. Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis. Nat Med. 2013 Apr; 19(4):421-8. PMID: 23475202.
      View in: PubMed
    32. Li X, Zhang W, Xu T, Ramsey J, Zhang L, Hill R, Hansen KC, Hesselberth JR, Zhao R. Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly. Nucleic Acids Res. 2013 Apr 01; 41(6):3805-18. PMID: 23393194.
      View in: PubMed
    33. Krueger AB, Dehdashti SJ, Southall N, Marugan JJ, Ferrer M, Li X, Ford HL, Zheng W, Zhao R. Identification of a selective small-molecule inhibitor series targeting the eyes absent 2 (Eya2) phosphatase activity. J Biomol Screen. 2013 Jan; 18(1):85-96. PMID: 22820394.
      View in: PubMed
    34. Liu W, Jankowska-Anyszka M, Piecyk K, Dickson L, Wallace A, Niedzwiecka A, Stepinski J, Stolarski R, Darzynkiewicz E, Kieft J, Zhao R, Jones DN, Davis RE. Structural basis for nematode eIF4E binding an m(2,2,7)G-Cap and its implications for translation initiation. Nucleic Acids Res. 2011 Nov 01; 39(20):8820-32. PMID: 21965542.
      View in: PubMed
    35. Deng Y, Deng H, Liu J, Han G, Malkoski S, Liu B, Zhao R, Wang XJ, Zhang Q. Transcriptional down-regulation of Brca1 and E-cadherin by CtBP1 in breast cancer. Mol Carcinog. 2012 Jun; 51(6):500-7. PMID: 21681822.
      View in: PubMed
    36. Guarnieri MT, Blagg BS, Zhao R. A high-throughput TNP-ATP displacement assay for screening inhibitors of ATP-binding in bacterial histidine kinases. Assay Drug Dev Technol. 2011 Apr; 9(2):174-83. PMID: 21050069.
      View in: PubMed
    37. Hong X, Zang J, White J, Wang C, Pan CH, Zhao R, Murphy RC, Dai S, Henson P, Kappler JW, Hagman J, Zhang G. Interaction of JMJD6 with single-stranded RNA. Proc Natl Acad Sci U S A. 2010 Aug 17; 107(33):14568-72. PMID: 20679243.
      View in: PubMed
    38. Liu W, Zhao R, McFarland C, Kieft J, Niedzwiecka A, Jankowska-Anyszka M, Stepinski J, Darzynkiewicz E, Jones DN, Davis RE. Structural insights into parasite eIF4E binding specificity for m7G and m2,2,7G mRNA caps. J Biol Chem. 2009 Nov 06; 284(45):31336-49. PMID: 19710013.
      View in: PubMed
    39. Zhang L, Xu T, Maeder C, Bud LO, Shanks J, Nix J, Guthrie C, Pleiss JA, Zhao R. Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2. Nat Struct Mol Biol. 2009 Jul; 16(7):731-9. PMID: 19525970.
      View in: PubMed
    40. Patrick AN, Schiemann BJ, Yang K, Zhao R, Ford HL. Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations. J Biol Chem. 2009 Jul 31; 284(31):20781-90. PMID: 19497856.
      View in: PubMed
    41. Yang K, Zhang L, Xu T, Heroux A, Zhao R. Crystal structure of the beta-finger domain of Prp8 reveals analogy to ribosomal proteins. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):13817-22. PMID: 18779563.
      View in: PubMed
    42. Guarnieri MT, Zhang L, Shen J, Zhao R. The Hsp90 inhibitor radicicol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ. J Mol Biol. 2008 May 23; 379(1):82-93. PMID: 18440021.
      View in: PubMed
    43. Shen J, Zhang L, Zhao R. Biochemical characterization of the ATPase and helicase activity of UAP56, an essential pre-mRNA splicing and mRNA export factor. J Biol Chem. 2007 Aug 03; 282(31):22544-50. PMID: 17562711.
      View in: PubMed
    44. Zhang L, Shen J, Guarnieri MT, Heroux A, Yang K, Zhao R. Crystal structure of the C-terminal domain of splicing factor Prp8 carrying retinitis pigmentosa mutants. Protein Sci. 2007 Jun; 16(6):1024-31. PMID: 17473007.
      View in: PubMed
    45. Gai D, Zhao R, Li D, Finkielstein CV, Chen XS. Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigen. Cell. 2004 Oct 01; 119(1):47-60. PMID: 15454080.
      View in: PubMed
    46. Kruse SW, Zhao R, Smith DP, Jones DN. Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster. Nat Struct Biol. 2003 Sep; 10(9):694-700. PMID: 12881720.
      View in: PubMed
    47. Li D, Zhao R, Lilyestrom W, Gai D, Zhang R, DeCaprio JA, Fanning E, Jochimiak A, Szakonyi G, Chen XS. Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen. Nature. 2003 May 29; 423(6939):512-8. PMID: 12774115.
      View in: PubMed
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