Spasms, Infantile
"Spasms, Infantile" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An epileptic syndrome characterized by the triad of infantile spasms, hypsarrhythmia, and arrest of psychomotor development at seizure onset. The majority present between 3-12 months of age, with spasms consisting of combinations of brief flexor or extensor movements of the head, trunk, and limbs. The condition is divided into two forms: cryptogenic (idiopathic) and symptomatic (secondary to a known disease process such as intrauterine infections; nervous system abnormalities; BRAIN DISEASES, METABOLIC, INBORN; prematurity; perinatal asphyxia; TUBEROUS SCLEROSIS; etc.). (From Menkes, Textbook of Child Neurology, 5th ed, pp744-8)
Descriptor ID |
D013036
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MeSH Number(s) |
C10.228.140.490.375.760 C10.228.140.490.493.875
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Concept/Terms |
Spasms, Infantile- Spasms, Infantile
- Infantile Spasm
- Infantile Spasms
- Lightning Attacks
- Attack, Lightning
- Attacks, Lightning
- Lightning Attack
- West Syndrome
- Syndrome, West
Jackknife Seizures- Jackknife Seizures
- Jackknife Seizure
- Seizure, Jackknife
- Seizures, Jackknife
Symptomatic Infantile Spasms- Symptomatic Infantile Spasms
- Infantile Spasm, Symptomatic
- Infantile Spasms, Symptomatic
- Spasm, Symptomatic Infantile
- Spasms, Symptomatic Infantile
- Symptomatic Infantile Spasm
- Symptomatic West Syndrome
- Syndrome, Symptomatic West
- West Syndrome, Symptomatic
Salaam Attacks- Salaam Attacks
- Attacks, Salaam
- Salaam Seizures
- Seizures, Salaam
Cryptogenic Infantile Spasms- Cryptogenic Infantile Spasms
- Cryptogenic Infantile Spasm
- Infantile Spasm, Cryptogenic
- Infantile Spasms, Cryptogenic
- Spasm, Cryptogenic Infantile
- Spasms, Cryptogenic Infantile
- Cryptogenic West Syndrome
- Syndrome, Cryptogenic West
- West Syndrome, Cryptogenic
Nodding Spasm- Nodding Spasm
- Nodding Spasms
- Spasm, Nodding
- Spasms, Nodding
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Below are MeSH descriptors whose meaning is more general than "Spasms, Infantile".
Below are MeSH descriptors whose meaning is more specific than "Spasms, Infantile".
This graph shows the total number of publications written about "Spasms, Infantile" by people in this website by year, and whether "Spasms, Infantile" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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2006 | 1 | 0 | 1 | 2010 | 1 | 0 | 1 | 2016 | 2 | 0 | 2 | 2017 | 3 | 1 | 4 | 2018 | 4 | 1 | 5 | 2019 | 6 | 3 | 9 | 2020 | 7 | 0 | 7 | 2021 | 11 | 0 | 11 | 2022 | 12 | 3 | 15 | 2023 | 8 | 1 | 9 | 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Spasms, Infantile" by people in Profiles.
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Saldaris JM, Jacoby P, Marsh ED, Suter B, Leonard H, Olson HE, Rajaraman R, Pestana-Knight E, Weisenberg J, Price D, Drummond C, Benke TA, Demarest S, Downs J. Adapting a measure of gross motor skills for individuals with CDKL5 deficiency disorder: A psychometric study. Epilepsy Res. 2024 Feb; 200:107287.
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Olson HE, Amin S, Bahi-Buisson N, Devinsky O, Marsh ED, Pestana-Knight E, Rajaraman RR, Aimetti AA, Rybak E, Kong F, Miller I, Hulihan J, Demarest S. Long-term treatment with ganaxolone for seizures associated with cyclin-dependent kinase-like 5 deficiency disorder: Two-year open-label extension follow-up. Epilepsia. 2024 Jan; 65(1):37-45.
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Neul JL, Benke TA, Marsh ED, Suter B, Silveira L, Fu C, Peters SU, Percy AK. Top caregiver concerns in Rett syndrome and related disorders: data from the US natural history study. J Neurodev Disord. 2023 10 13; 15(1):33.
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Daniels C, Greene C, Smith L, Pestana-Knight E, Demarest S, Zhang B, Benke TA, Poduri A, Olson HE. CDKL5 deficiency disorder and other infantile-onset genetic epilepsies. Dev Med Child Neurol. 2024 Apr; 66(4):456-468.
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Ziniel SI, Mackie A, Saldaris J, Leonard H, Jacoby P, Marsh ED, Suter B, Pestana-Knight E, Olson HE, Price D, Weisenberg J, Rajaraman R, VanderVeen G, Benke TA, Downs J, Demarest S. The development, content and response process validation of a caregiver-reported severity measure for CDKL5 deficiency disorder. Epilepsy Res. 2023 11; 197:107231.
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Olson HE, Demarest S, Pestana-Knight E, Moosa AN, Zhang X, P?rez-P?rez JR, Weisenberg J, O'Connor Prange E, Marsh ED, Rajaraman RR, Suter B, Katyayan A, Haviland I, Daniels C, Zhang B, Greene C, DeLeo M, Swanson L, Love-Nichols J, Benke T, Harini C, Poduri A. Epileptic spasms in CDKL5 deficiency disorder: Delayed treatment and poor response to first-line therapies. Epilepsia. 2023 07; 64(7):1821-1832.
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Saldaris J, Leonard H, Wong K, Jacoby P, Spence M, Marsh ED, Benke TA, Demarest S, Downs J. Validating the Communication and Symbolic Behavior Scales-Developmental Profile Infant-Toddler Checklist (CSBS-DP ITC) Beyond Infancy in the CDKL5 Deficiency Disorder. J Autism Dev Disord. 2024 Jul; 54(7):2526-2535.
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Demarest S, Jeste S, Agarwal N, Arkilo D, Asgharnejad M, Hsiao S, Thibert R. Efficacy, safety, and tolerability of soticlestat as adjunctive therapy for the treatment of seizures in patients with Dup15q syndrome or CDKL5 deficiency disorder in an open-label signal-finding phase II study (ARCADE). Epilepsy Behav. 2023 05; 142:109173.
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Saby JN, Peters SU, Benke TA, Standridge SM, Swanson LC, Lieberman DN, Olson HE, Key AP, Percy AK, Neul JL, Nelson CA, Roberts TPL, Marsh ED. Comparison of evoked potentials across four related developmental encephalopathies. J Neurodev Disord. 2023 03 04; 15(1):10.
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Saldaris JM, Jacoby P, Leonard H, Benke TA, Demarest S, Marsh ED, Downs J. Psychometric properties of QI-Disability in CDKL5 Deficiency Disorder: Establishing readiness for clinical trials. Epilepsy Behav. 2023 02; 139:109069.
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