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Mamuka Kvaratskhelia

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Research 
    Collapse research activities and funding
    R01AI184419     (KVARATSKHELIA, MAMUKA)Aug 1, 2024 - Jul 31, 2029
    NIH
    Role of HIV-1 integrase in virion morphogenesis and its targeting by allosteric integrase inhibitors
    Role: Principal Investigator
    R01AI162665     (KVARATSKHELIA, MAMUKA)Feb 8, 2022 - Jan 31, 2027
    NIH
    Roles of HIV-1 capsid-binding FG-motif containing cellular cofactors in infection
    Role: Principal Investigator
    R01AI157802     (KVARATSKHELIA, MAMUKA)Sep 21, 2020 - Aug 31, 2025
    NIH
    Ultra-potent HIV capsid inhibitors
    Role: Principal Investigator
    T32AI150547     (CAMPBELL, THOMAS B.)Jul 1, 2020 - Jun 30, 2025
    NIH
    Training Program for Antiretroviral Discovery, Evaluation and Application Research (ADEAR)
    Role: Co-Principal Investigator
    R01AI143649     (KVARATSKHELIA, MAMUKA)Mar 15, 2019 - Feb 29, 2024
    NIH
    Multimeric HIV-1 Integrase Inhibitors
    Role: Principal Investigator
    R01AI129862     (MELIKIAN, GREGORY B)Mar 24, 2017 - May 31, 2027
    NIH
    Imaging early steps of HIV-1 infection and virus-host factor interactions
    Role: Co-Principal Investigator
    R01AI110310     (KVARATSKHELIA, MAMUKA)May 1, 2014 - Apr 30, 2020
    NIH
    Multimeric HIV-1 Integrase Inhibitors
    Role: Principal Investigator
    R21AI109522     (KVARATSKHELIA, MAMUKA)Feb 10, 2014 - Jan 31, 2017
    NIH
    Cellular Cofactors of Murine Leukemia Virus Integrase
    Role: Principal Investigator
    R01AI081581     (KVARATSKHELIA, MAMUKA)Dec 15, 2009 - Nov 30, 2013
    NIH
    Novel Assay for HIV-1 Integrase Inhibitors
    Role: Principal Investigator
    K02AI077341     (KVARATSKHELIA, MAMUKA)Dec 1, 2007 - Nov 30, 2012
    NIH
    HIV-1 Integrase Structure and Function as a Therapeutic Target
    Role: Principal Investigator
    R21AI067086     (KVARATSKHELIA, MAMUKA)Apr 1, 2006 - Mar 31, 2009
    NIH
    HIV-1 Gag structure as a therapeutic target
    Role: Principal Investigator
    R01AI062520     (KVARATSKHELIA, MAMUKA)Jul 1, 2004 - Oct 31, 2021
    NIH
    Structure and function of HIV-1 integrase
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Layish B, Goli R, Flick H, Huang SW, Zhang RZ, Kvaratskhelia M, Kane M. Virus specificity and nucleoporin requirements for MX2 activity are affected by GTPase function and capsid-CypA interactions. bioRxiv. 2023 Nov 17. PMID: 38014352.
      View in: PubMed
    2. Smith S, Seth J, Midkiff A, Stahl R, Syu YC, Shkriabai N, Kvaratskhelia M, Musier-Forsyth K, Jain P, Green PL, Panfil AR. The Pleiotropic Effects of YBX1 on HTLV-1 Transcription. Int J Mol Sci. 2023 Aug 23; 24(17). PMID: 37685922.
      View in: PubMed
    3. Li M, Oliveira Passos D, Shan Z, Smith SJ, Sun Q, Biswas A, Choudhuri I, Strutzenberg TS, Haldane A, Deng N, Li Z, Zhao XZ, Briganti L, Kvaratskhelia M, Burke TR, Levy RM, Hughes SH, Craigie R, Lyumkis D. Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. Sci Adv. 2023 07 21; 9(29):eadg5953. PMID: 37478179.
      View in: PubMed
    4. Singer MR, Dinh T, Levintov L, Annamalai AS, Rey JS, Briganti L, Cook NJ, Pye VE, Taylor IA, Kim K, Engelman AN, Kim B, Perilla JR, Kvaratskhelia M, Cherepanov P. The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function. mBio. 2023 02 28; 14(1):e0356022. PMID: 36744954.
      View in: PubMed
    5. Wei G, Iqbal N, Courouble VV, Francis AC, Singh PK, Hudait A, Annamalai AS, Bester S, Huang SW, Shkriabai N, Briganti L, Haney R, KewalRamani VN, Voth GA, Engelman AN, Melikyan GB, Griffin PR, Asturias F, Kvaratskhelia M. Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection. Nat Commun. 2022 10 06; 13(1):5879. PMID: 36202818.
      View in: PubMed
    6. Bester SM, Adu-Ampratwum D, Annamalai AS, Wei G, Briganti L, Murphy BC, Haney R, Fuchs JR, Kvaratskhelia M. Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir. mBio. 2022 10 26; 13(5):e0180422. PMID: 36190128.
      View in: PubMed
    7. Sapp N, Burge N, Cox K, Prakash P, Balasubramaniam M, Thapa S, Christensen D, Li M, Linderberger J, Kvaratskhelia M, Pandhare J, Craigie R, Poirier MG, Dash C. HIV-1 Preintegration Complex Preferentially Integrates the Viral DNA into Nucleosomes Containing Trimethylated Histone 3-Lysine 36 Modification and Flanking Linker DNA. J Virol. 2022 09 28; 96(18):e0101122. PMID: 36094316.
      View in: PubMed
    8. Shema Mugisha C, Dinh T, Kumar A, Tenneti K, Eschbach JE, Davis K, Gifford R, Kvaratskhelia M, Kutluay SB. Emergence of Compensatory Mutations Reveals the Importance of Electrostatic Interactions between HIV-1 Integrase and Genomic RNA. mBio. 2022 10 26; 13(5):e0043122. PMID: 35975921.
      View in: PubMed
    9. Engelman AN, Kvaratskhelia M. Multimodal Functionalities of HIV-1 Integrase. Viruses. 2022 04 28; 14(5). PMID: 35632668.
      View in: PubMed
    10. Adu-Ampratwum D, Pan Y, Koneru PC, Antwi J, Hoyte AC, Kessl J, Griffin PR, Kvaratskhelia M, Fuchs JR, Larue RC. Identification and Optimization of a Novel HIV-1 Integrase Inhibitor. ACS Omega. 2022 Feb 08; 7(5):4482-4491. PMID: 35155940.
      View in: PubMed
    11. Liu S, Koneru PC, Li W, Pathirage C, Engelman AN, Kvaratskhelia M, Musier-Forsyth K. HIV-1 integrase binding to genomic RNA 5'-UTR induces local structural changes in vitro and in virio. Retrovirology. 2021 11 22; 18(1):37. PMID: 34809662.
      View in: PubMed
    12. Maehigashi T, Ahn S, Kim UI, Lindenberger J, Oo A, Koneru PC, Mahboubi B, Engelman AN, Kvaratskhelia M, Kim K, Kim B. A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site. PLoS Pathog. 2021 07; 17(7):e1009671. PMID: 34293041.
      View in: PubMed
    13. Li Z, Wang-Heaton H, Cartwright BM, Makinwa Y, Hilton BA, Musich PR, Shkriabai N, Kvaratskhelia M, Guan S, Chen Q, Yu X, Zou Y. ATR prevents Ca2+ overload-induced necrotic cell death through phosphorylation-mediated inactivation of PARP1 without DNA damage signaling. FASEB J. 2021 05; 35(5):e21373. PMID: 33811702.
      View in: PubMed
    14. Rebensburg SV, Wei G, Larue RC, Lindenberger J, Francis AC, Annamalai AS, Morrison J, Shkriabai N, Huang SW, KewalRamani V, Poeschla EM, Melikyan GB, Kvaratskhelia M. Sec24C is an HIV-1 host dependency factor crucial for virus replication. Nat Microbiol. 2021 04; 6(4):435-444. PMID: 33649557.
      View in: PubMed
    15. Bester SM, Wei G, Zhao H, Adu-Ampratwum D, Iqbal N, Courouble VV, Francis AC, Annamalai AS, Singh PK, Shkriabai N, Van Blerkom P, Morrison J, Poeschla EM, Engelman AN, Melikyan GB, Griffin PR, Fuchs JR, Asturias FJ, Kvaratskhelia M. Structural and mechanistic bases for a potent HIV-1 capsid inhibitor. Science. 2020 10 16; 370(6514):360-364. PMID: 33060363.
      View in: PubMed
    16. Elliott JL, Eschbach JE, Koneru PC, Li W, Puray-Chavez M, Townsend D, Lawson DQ, Engelman AN, Kvaratskhelia M, Kutluay SB. Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis. Elife. 2020 09 22; 9. PMID: 32960169.
      View in: PubMed
    17. Tse C, Wickstrom L, Kvaratskhelia M, Gallicchio E, Levy R, Deng N. Exploring the Free-Energy Landscape and Thermodynamics of Protein-Protein Association. Biophys J. 2020 09 15; 119(6):1226-1238. PMID: 32877664.
      View in: PubMed
    18. Esposito F, Sechi M, Pala N, Sanna A, Koneru PC, Kvaratskhelia M, Naesens L, Corona A, Grandi N, di Santo R, D'Amore VM, Di Leva FS, Novellino E, Cosconati S, Tramontano E. Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors. Antiviral Res. 2020 02; 174:104671. PMID: 31812637.
      View in: PubMed
    19. Koneru PC, Francis AC, Deng N, Rebensburg SV, Hoyte AC, Lindenberger J, Adu-Ampratwum D, Larue RC, Wempe MF, Engelman AN, Lyumkis D, Fuchs JR, Levy RM, Melikyan GB, Kvaratskhelia M. HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors. Elife. 2019 05 23; 8. PMID: 31120420.
      View in: PubMed
    20. Al-Saleem J, Dirksen WP, Martinez MP, Shkriabai N, Kvaratskhelia M, Ratner L, Green PL. HTLV-1 Tax-1 interacts with SNX27 to regulate cellular localization of the HTLV-1 receptor molecule, GLUT1. PLoS One. 2019; 14(3):e0214059. PMID: 30897179.
      View in: PubMed
    21. Wilson TA, Koneru PC, Rebensburg SV, Lindenberger JJ, Kobe MJ, Cockroft NT, Adu-Ampratwum D, Larue RC, Kvaratskhelia M, Fuchs JR. An Isoquinoline Scaffold as a Novel Class of Allosteric HIV-1 Integrase Inhibitors. ACS Med Chem Lett. 2019 Feb 14; 10(2):215-220. PMID: 30783506.
      View in: PubMed
    22. Rivieccio E, Tartaglione L, Esposito V, Dell'Aversano C, Koneru PC, Scuotto M, Virgilio A, Mayol L, Kvaratskhelia M, Varra M. Structural studies and biological evaluation of T30695 variants modified with single chiral glycerol-T reveal the importance of LEDGF/p75 for the aptamer anti-HIV-integrase activities. Biochim Biophys Acta Gen Subj. 2019 02; 1863(2):351-361. PMID: 30414444.
      View in: PubMed
    23. Kane M, Rebensburg SV, Takata MA, Zang TM, Yamashita M, Kvaratskhelia M, Bieniasz PD. Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2. Elife. 2018 08 07; 7. PMID: 30084827.
      View in: PubMed
    24. Zhao XZ, M?tifiot M, Kiselev E, Kessl JJ, Maddali K, Marchand C, Kvaratskhelia M, Pommier Y, Burke TR. HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence. Molecules. 2018 Jul 26; 23(8). PMID: 30049955.
      View in: PubMed
    25. Lu W, Tirumuru N, St Gelais C, Koneru PC, Liu C, Kvaratskhelia M, He C, Wu L. N6-Methyladenosine-binding proteins suppress HIV-1 infectivity and viral production. J Biol Chem. 2018 08 24; 293(34):12992-13005. PMID: 29976753.
      View in: PubMed
    26. Panfil AR, Al-Saleem J, Howard CM, Shkriabai N, Kvaratskhelia M, Green PL. Stability of the HTLV-1 Antisense-Derived Protein, HBZ, Is Regulated by the E3 Ubiquitin-Protein Ligase, UBR5. Front Microbiol. 2018; 9:80. PMID: 29441057.
      View in: PubMed
    27. Hoyte AC, Jamin AV, Koneru PC, Kobe MJ, Larue RC, Fuchs JR, Engelman AN, Kvaratskhelia M. Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing. J Biol Chem. 2017 12 01; 292(48):19814-19825. PMID: 28972144.
      View in: PubMed
    28. Madison MK, Lawson DQ, Elliott J, Ozant?rk AN, Koneru PC, Townsend D, Errando M, Kvaratskhelia M, Kutluay SB. Allosteric HIV-1 Integrase Inhibitors Lead to Premature Degradation of the Viral RNA Genome and Integrase in Target Cells. J Virol. 2017 09 01; 91(17). PMID: 28615207.
      View in: PubMed
    29. Winans S, Larue RC, Abraham CM, Shkriabai N, Skopp A, Winkler D, Kvaratskhelia M, Beemon KL. The FACT Complex Promotes Avian Leukosis Virus DNA Integration. J Virol. 2017 04 01; 91(7). PMID: 28122976.
      View in: PubMed
    30. Passos DO, Li M, Yang R, Rebensburg SV, Ghirlando R, Jeon Y, Shkriabai N, Kvaratskhelia M, Craigie R, Lyumkis D. Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome. Science. 2017 01 06; 355(6320):89-92. PMID: 28059769.
      View in: PubMed
    31. Al-Saleem J, Kvaratskhelia M, Green PL. Methods for Identifying and Examining HTLV-1 HBZ Post-translational Modifications. Methods Mol Biol. 2017; 1582:111-126. PMID: 28357666.
      View in: PubMed
    32. Ablenas CJ, Liu HW, Shkriabai N, Kvaratskhelia M, Cosa G, G?tte M. Dynamic Interconversions of HCV Helicase Binding Modes on the Nucleic Acid Substrate. ACS Infect Dis. 2017 01 13; 3(1):99-109. PMID: 28081608.
      View in: PubMed
    33. Ngure M, Issur M, Shkriabai N, Liu HW, Cosa G, Kvaratskhelia M, G?tte M. Interactions of the Disordered Domain II of Hepatitis C Virus NS5A with Cyclophilin A, NS5B, and Viral RNA Show Extensive Overlap. ACS Infect Dis. 2016 11 11; 2(11):839-851. PMID: 27676132.
      View in: PubMed
    34. Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy RM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M, Arnold E. A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain. J Biol Chem. 2016 Nov 04; 291(45):23569-23577. PMID: 27645997.
      View in: PubMed
    35. Kudryashova E, Koneru PC, Kvaratskhelia M, Str?mstedt AA, Lu W, Kudryashov DS. Thermodynamic instability of viral proteins is a pathogen-associated molecular pattern targeted by human defensins. Sci Rep. 2016 09 01; 6:32499. PMID: 27581352.
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    36. Pi F, Zhao Z, Chelikani V, Yoder K, Kvaratskhelia M, Guo P. Development of Potent Antiviral Drugs Inspired by Viral Hexameric DNA-Packaging Motors with Revolving Mechanism. J Virol. 2016 09 15; 90(18):8036-46. PMID: 27356896.
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    37. Kessl JJ, Kutluay SB, Townsend D, Rebensburg S, Slaughter A, Larue RC, Shkriabai N, Bakouche N, Fuchs JR, Bieniasz PD, Kvaratskhelia M. HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis. Cell. 2016 Aug 25; 166(5):1257-1268.e12. PMID: 27565348.
      View in: PubMed
    38. Deng N, Hoyte A, Mansour YE, Mohamed MS, Fuchs JR, Engelman AN, Kvaratskhelia M, Levy R. Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies. Protein Sci. 2016 11; 25(11):1911-1917. PMID: 27503276.
      View in: PubMed
    39. Agharbaoui FE, Hoyte AC, Ferro S, Gitto R, Buemi MR, Fuchs JR, Kvaratskhelia M, De Luca L. Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase. Eur J Med Chem. 2016 Nov 10; 123:673-683. PMID: 27517812.
      View in: PubMed
    40. Chen TH, Tanimoto A, Shkriabai N, Kvaratskhelia M, Wysocki V, Gopalan V. Use of chemical modification and mass spectrometry to identify substrate-contacting sites in proteinaceous RNase P, a tRNA processing enzyme. Nucleic Acids Res. 2016 06 20; 44(11):5344-55. PMID: 27166372.
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    41. Feng L, Dharmarajan V, Serrao E, Hoyte A, Larue RC, Slaughter A, Sharma A, Plumb MR, Kessl JJ, Fuchs JR, Bushman FD, Engelman AN, Griffin PR, Kvaratskhelia M. The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency. ACS Chem Biol. 2016 05 20; 11(5):1313-21. PMID: 26910179.
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    42. Crowe BL, Larue RC, Yuan C, Hess S, Kvaratskhelia M, Foster MP. Structure of the Brd4 ET domain bound to a C-terminal motif from ?-retroviral integrases reveals a conserved mechanism of interaction. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):2086-91. PMID: 26858406.
      View in: PubMed
    43. Kessl JJ, Sharma A, Kvaratskhelia M. Methods for the Analyses of Inhibitor-Induced Aberrant Multimerization of HIV-1 Integrase. Methods Mol Biol. 2016; 1354:149-64. PMID: 26714710.
      View in: PubMed
    44. Singh PK, Plumb MR, Ferris AL, Iben JR, Wu X, Fadel HJ, Luke BT, Esnault C, Poeschla EM, Hughes SH, Kvaratskhelia M, Levin HL. LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes. Genes Dev. 2015 Nov 01; 29(21):2287-97. PMID: 26545813.
      View in: PubMed
    45. Cherian MA, Baydoun HH, Al-Saleem J, Shkriabai N, Kvaratskhelia M, Green P, Ratner L. Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein. J Biol Chem. 2015 Oct 23; 290(43):26270-81. PMID: 26324707.
      View in: PubMed
    46. Feng L, Larue RC, Slaughter A, Kessl JJ, Kvaratskhelia M. HIV-1 integrase multimerization as a therapeutic target. Curr Top Microbiol Immunol. 2015; 389:93-119. PMID: 25778682.
      View in: PubMed
    47. Hilton B, Shkriabai N, Musich PR, Kvaratskhelia M, Shell S, Zou Y. A new structural insight into XPA-DNA interactions. Biosci Rep. 2014 Dec 12; 34(6):e00162. PMID: 25385088.
      View in: PubMed
    48. Slaughter A, Jurado KA, Deng N, Feng L, Kessl JJ, Shkriabai N, Larue RC, Fadel HJ, Patel PA, Jena N, Fuchs JR, Poeschla E, Levy RM, Engelman A, Kvaratskhelia M. The mechanism of H171T resistance reveals the importance of Nd-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase. Retrovirology. 2014 Nov 25; 11:100. PMID: 25421939.
      View in: PubMed
    49. Dissinger N, Shkriabai N, Hess S, Al-Saleem J, Kvaratskhelia M, Green PL. Identification and characterization of HTLV-1 HBZ post-translational modifications. PLoS One. 2014; 9(11):e112762. PMID: 25389759.
      View in: PubMed
    50. Kvaratskhelia M, Sharma A, Larue RC, Serrao E, Engelman A. Molecular mechanisms of retroviral integration site selection. Nucleic Acids Res. 2014; 42(16):10209-25. PMID: 25147212.
      View in: PubMed
    51. Shkriabai N, Dharmarajan V, Slaughter A, Kessl JJ, Larue RC, Feng L, Fuchs JR, Griffin PR, Kvaratskhelia M. A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase. J Biol Chem. 2014 Sep 19; 289(38):26430-26440. PMID: 25118283.
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    52. Fadel HJ, Morrison JH, Saenz DT, Fuchs JR, Kvaratskhelia M, Ekker SC, Poeschla EM. TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism. J Virol. 2014 Sep 01; 88(17):9704-17. PMID: 24942577.
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    53. Sharma A, Slaughter A, Jena N, Feng L, Kessl JJ, Fadel HJ, Malani N, Male F, Wu L, Poeschla E, Bushman FD, Fuchs JR, Kvaratskhelia M. A new class of multimerization selective inhibitors of HIV-1 integrase. PLoS Pathog. 2014 May; 10(5):e1004171. PMID: 24874515.
      View in: PubMed
    54. Aiyer S, Swapna GV, Malani N, Aramini JM, Schneider WM, Plumb MR, Ghanem M, Larue RC, Sharma A, Studamire B, Kvaratskhelia M, Bushman FD, Montelione GT, Roth MJ. Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction. Nucleic Acids Res. 2014 May; 42(9):5917-28. PMID: 24623816.
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    55. Larue RC, Plumb MR, Crowe BL, Shkriabai N, Sharma A, DiFiore J, Malani N, Aiyer SS, Roth MJ, Bushman FD, Foster MP, Kvaratskhelia M. Bimodal high-affinity association of Brd4 with murine leukemia virus integrase and mononucleosomes. Nucleic Acids Res. 2014 Apr; 42(8):4868-81. PMID: 24520112.
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    56. Sharma A, Larue RC, Plumb MR, Malani N, Male F, Slaughter A, Kessl JJ, Shkriabai N, Coward E, Aiyer SS, Green PL, Wu L, Roth MJ, Bushman FD, Kvaratskhelia M. BET proteins promote efficient murine leukemia virus integration at transcription start sites. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):12036-41. PMID: 23818621.
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    57. Engelman A, Kessl JJ, Kvaratskhelia M. Allosteric inhibition of HIV-1 integrase activity. Curr Opin Chem Biol. 2013 Jun; 17(3):339-45. PMID: 23647983.
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    58. Feng L, Sharma A, Slaughter A, Jena N, Koh Y, Shkriabai N, Larue RC, Patel PA, Mitsuya H, Kessl JJ, Engelman A, Fuchs JR, Kvaratskhelia M. The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors. J Biol Chem. 2013 May 31; 288(22):15813-20. PMID: 23615903.
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    59. Jurado KA, Wang H, Slaughter A, Feng L, Kessl JJ, Koh Y, Wang W, Ballandras-Colas A, Patel PA, Fuchs JR, Kvaratskhelia M, Engelman A. Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):8690-5. PMID: 23610442.
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    60. Eidahl JO, Crowe BL, North JA, McKee CJ, Shkriabai N, Feng L, Plumb M, Graham RL, Gorelick RJ, Hess S, Poirier MG, Foster MP, Kvaratskhelia M. Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes. Nucleic Acids Res. 2013 Apr 01; 41(6):3924-36. PMID: 23396443.
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    61. Wang H, Jurado KA, Wu X, Shun MC, Li X, Ferris AL, Smith SJ, Patel PA, Fuchs JR, Cherepanov P, Kvaratskhelia M, Hughes SH, Engelman A. HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor. Nucleic Acids Res. 2012 Dec; 40(22):11518-30. PMID: 23042676.
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    62. Doueiri R, Anupam R, Kvaratskhelia M, Green KB, Lairmore MD, Green PL. Comparative host protein interactions with HTLV-1 p30 and HTLV-2 p28: insights into difference in pathobiology of human retroviruses. Retrovirology. 2012 Aug 09; 9:64. PMID: 22876852.
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    63. Larue R, Gupta K, Wuensch C, Shkriabai N, Kessl JJ, Danhart E, Feng L, Taltynov O, Christ F, Van Duyne GD, Debyser Z, Foster MP, Kvaratskhelia M. Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2). J Biol Chem. 2012 Oct 05; 287(41):34044-58. PMID: 22872640.
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    64. Kessl JJ, Jena N, Koh Y, Taskent-Sezgin H, Slaughter A, Feng L, de Silva S, Wu L, Le Grice SF, Engelman A, Fuchs JR, Kvaratskhelia M. Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors. J Biol Chem. 2012 May 11; 287(20):16801-11. PMID: 22437836.
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    65. Kessl JJ, Li M, Ignatov M, Shkriabai N, Eidahl JO, Feng L, Musier-Forsyth K, Craigie R, Kvaratskhelia M. FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75. Nucleic Acids Res. 2011 Nov 01; 39(20):9009-22. PMID: 21771857.
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    66. Ditzler MA, Bose D, Shkriabai N, Marchand B, Sarafianos SG, Kvaratskhelia M, Burke DH. Broad-spectrum aptamer inhibitors of HIV reverse transcriptase closely mimic natural substrates. Nucleic Acids Res. 2011 Oct; 39(18):8237-47. PMID: 21727088.
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    67. Anupam R, Datta A, Kesic M, Green-Church K, Shkriabai N, Kvaratskhelia M, Lairmore MD. Human T-lymphotropic virus type 1 p30 interacts with REGgamma and modulates ATM (ataxia telangiectasia mutated) to promote cell survival. J Biol Chem. 2011 Mar 04; 286(9):7661-8. PMID: 21216954.
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    68. Ranji A, Shkriabai N, Kvaratskhelia M, Musier-Forsyth K, Boris-Lawrie K. Features of double-stranded RNA-binding domains of RNA helicase A are necessary for selective recognition and translation of complex mRNAs. J Biol Chem. 2011 Feb 18; 286(7):5328-37. PMID: 21123178.
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    69. Raghavendra NK, Shkriabai N, Graham RLj, Hess S, Kvaratskhelia M, Wu L. Identification of host proteins associated with HIV-1 preintegration complexes isolated from infected CD4+ cells. Retrovirology. 2010 Aug 11; 7:66. PMID: 20698996.
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    70. Kessl JJ, McKee CJ, Eidahl JO, Shkriabai N, Katz A, Kvaratskhelia M. HIV-1 Integrase-DNA Recognition Mechanisms. Viruses. 2009 12; 1(3):713-36. PMID: 21994566.
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    71. Kessl JJ, Eidahl JO, Shkriabai N, Zhao Z, McKee CJ, Hess S, Burke TR, Kvaratskhelia M. An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule. Mol Pharmacol. 2009 Oct; 76(4):824-32. PMID: 19638533.
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    72. Shell SM, Li Z, Shkriabai N, Kvaratskhelia M, Brosey C, Serrano MA, Chazin WJ, Musich PR, Zou Y. Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A. J Biol Chem. 2009 Sep 04; 284(36):24213-22. PMID: 19586908.
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    73. Fowler JD, Brown JA, Kvaratskhelia M, Suo Z. Probing conformational changes of human DNA polymerase lambda using mass spectrometry-based protein footprinting. J Mol Biol. 2009 Jul 17; 390(3):368-79. PMID: 19467241.
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    74. Motari E, Zheng X, Su X, Liu Y, Kvaratskhelia M, Freitas M, Wang PG. Analysis of Recombinant CD24 Glycans by MALDI-TOF-MS Reveals Prevalence of Sialyl-T Antigen. Am J Biomed Sci. 2009 Jan 01; 1(1):1-11. PMID: 20407596.
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    75. McKee CJ, Kessl JJ, Norris JO, Shkriabai N, Kvaratskhelia M. Mass spectrometry-based footprinting of protein-protein interactions. Methods. 2009 Apr; 47(4):304-7. PMID: 19015031.
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    76. Wendeler M, Lee HF, Bermingham A, Miller JT, Chertov O, Bona MK, Baichoo NS, Ehteshami M, Beutler J, O'Keefe BR, G?tte M, Kvaratskhelia M, Le Grice S. Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity. ACS Chem Biol. 2008 Oct 17; 3(10):635-44. PMID: 18831589.
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    77. McKee CJ, Kessl JJ, Shkriabai N, Dar MJ, Engelman A, Kvaratskhelia M. Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein. J Biol Chem. 2008 Nov 14; 283(46):31802-12. PMID: 18801737.
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    78. Kvaratskhelia M, Grice SF. Structural analysis of protein-RNA interactions with mass spectrometry. Methods Mol Biol. 2008; 488:213-9. PMID: 18982294.
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    79. Zhao Z, McKee CJ, Kessl JJ, Santos WL, Daigle JE, Engelman A, Verdine G, Kvaratskhelia M. Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA binding. J Biol Chem. 2008 Feb 29; 283(9):5632-41. PMID: 18093980.
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    80. Bradley CM, Jones S, Huang Y, Suzuki Y, Kvaratskhelia M, Hickman AB, Craigie R, Dyda F. Structural basis for dimerization of LAP2alpha, a component of the nuclear lamina. Structure. 2007 Jun; 15(6):643-53. PMID: 17562312.
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    81. Deval J, D'Abramo CM, Zhao Z, McCormick S, Coutsinos D, Hess S, Kvaratskhelia M, G?tte M. High resolution footprinting of the hepatitis C virus polymerase NS5B in complex with RNA. J Biol Chem. 2007 Jun 08; 282(23):16907-16. PMID: 17449464.
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    82. Datta SA, Zhao Z, Clark PK, Tarasov S, Alexandratos JN, Campbell SJ, Kvaratskhelia M, Lebowitz J, Rein A. Interactions between HIV-1 Gag molecules in solution: an inositol phosphate-mediated switch. J Mol Biol. 2007 Jan 19; 365(3):799-811. PMID: 17098251.
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    83. Marchand C, Krajewski K, Lee HF, Antony S, Johnson AA, Amin R, Roller P, Kvaratskhelia M, Pommier Y. Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites. Nucleic Acids Res. 2006; 34(18):5157-65. PMID: 16998183.
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    84. Shkriabai N, Datta SA, Zhao Z, Hess S, Rein A, Kvaratskhelia M. Interactions of HIV-1 Gag with assembly cofactors. Biochemistry. 2006 Apr 04; 45(13):4077-83. PMID: 16566581.
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    85. Liu Y, Kvaratskhelia M, Hess S, Qu Y, Zou Y. Modulation of replication protein A function by its hyperphosphorylation-induced conformational change involving DNA binding domain B. J Biol Chem. 2005 Sep 23; 280(38):32775-83. PMID: 16006651.
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    86. Shell SM, Hess S, Kvaratskhelia M, Zou Y. Mass spectrometric identification of lysines involved in the interaction of human replication protein a with single-stranded DNA. Biochemistry. 2005 Jan 25; 44(3):971-8. PMID: 15654753.
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    87. Williams KL, Zhang Y, Shkriabai N, Karki RG, Nicklaus MC, Kotrikadze N, Hess S, Le Grice SF, Craigie R, Pathak VK, Kvaratskhelia M. Mass spectrometric analysis of the HIV-1 integrase-pyridoxal 5'-phosphate complex reveals a new binding site for a nucleotide inhibitor. J Biol Chem. 2005 Mar 04; 280(9):7949-55. PMID: 15615720.
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    88. Kvaratskhelia M, Clark PK, Hess S, Melder DC, Federspiel MJ, Hughes SH. Identification of glycosylation sites in the SU component of the Avian Sarcoma/Leukosis virus Envelope Glycoprotein (Subgroup A) by mass spectrometry. Virology. 2004 Aug 15; 326(1):171-81. PMID: 15262505.
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    89. Shkriabai N, Patil SS, Hess S, Budihas SR, Craigie R, Burke TR, Le Grice SF, Kvaratskhelia M. Identification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry. Proc Natl Acad Sci U S A. 2004 May 04; 101(18):6894-9. PMID: 15118107.
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    90. Lener D, Kvaratskhelia M, Le Grice SF. Nonpolar thymine isosteres in the Ty3 polypurine tract DNA template modulate processing and provide a model for its recognition by Ty3 reverse transcriptase. J Biol Chem. 2003 Jul 18; 278(29):26526-32. PMID: 12730227.
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    91. Kvaratskhelia M, Budihas SR, Le Grice SF. Pre-existing distortions in nucleic acid structure aid polypurine tract selection by HIV-1 reverse transcriptase. J Biol Chem. 2002 May 10; 277(19):16689-96. PMID: 11875059.
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    92. Kvaratskhelia M, Wardleworth BN, Bond CS, Fogg JM, Lilley DM, White MF. Holliday junction resolution is modulated by archaeal chromatin components in vitro. J Biol Chem. 2002 Jan 25; 277(4):2992-6. PMID: 11709558.
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    93. Fogg JM, Kvaratskhelia M, White MF, Lilley DM. Distortion of DNA junctions imposed by the binding of resolving enzymes: a fluorescence study. J Mol Biol. 2001 Nov 02; 313(4):751-64. PMID: 11697901.
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    94. Bond CS, Kvaratskhelia M, Richard D, White MF, Hunter WN. Structure of Hjc, a Holliday junction resolvase, from Sulfolobus solfataricus. Proc Natl Acad Sci U S A. 2001 May 08; 98(10):5509-14. PMID: 11331763.
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    95. Kvaratskhelia M, Wardleworth BN, White MF. Multiple Holliday junction resolving enzyme activities in the Crenarchaeota and Euryarchaeota. FEBS Lett. 2001 Mar 02; 491(3):243-6. PMID: 11240135.
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    96. Kvaratskhelia M, Wardleworth BN, Norman DG, White MF. A conserved nuclease domain in the archaeal Holliday junction resolving enzyme Hjc. J Biol Chem. 2000 Aug 18; 275(33):25540-6. PMID: 10940317.
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    97. Wardleworth BN, Kvaratskhelia M, White MF. Site-directed mutagenesis of the yeast resolving enzyme Cce1 reveals catalytic residues and relationship with the intron-splicing factor Mrs1. J Biol Chem. 2000 Aug 04; 275(31):23725-8. PMID: 10825168.
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    98. Kvaratskhelia M, White MF. Two Holliday junction resolving enzymes in Sulfolobus solfataricus. J Mol Biol. 2000 Apr 07; 297(4):923-32. PMID: 10736227.
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    99. Kvaratskhelia M, White MF. An archaeal Holliday junction resolving enzyme from Sulfolobus solfataricus exhibits unique properties. J Mol Biol. 2000 Jan 14; 295(2):193-202. PMID: 10623519.
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    100. Kvaratskhelia M, George SJ, Cooper A, White MF. Quantitation of metal ion and DNA junction binding to the Holliday junction endonuclease Cce1. Biochemistry. 1999 Dec 14; 38(50):16613-9. PMID: 10600123.
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    101. George SJ, Kvaratskhelia M, Dilworth MJ, Thorneley RN. Reversible alkaline inactivation of lignin peroxidase involves the release of both the distal and proximal site calcium ions and bishistidine co-ordination of the haem. Biochem J. 1999 Nov 15; 344 Pt 1:237-44. PMID: 10548556.
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    102. Fraser HI, Kvaratskhelia M, White MF. The two analogous phosphoglycerate mutases of Escherichia coli. FEBS Lett. 1999 Jul 23; 455(3):344-8. PMID: 10437801.
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    103. Kvaratskhelia M, George SJ, Thorneley RN. Salicylic acid is a reducing substrate and not an effective inhibitor of ascorbate peroxidase. J Biol Chem. 1997 Aug 22; 272(34):20998-1001. PMID: 9261100.
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    104. Kvaratskhelia M, Winkel C, Thorneley RN. Purification and characterization of a novel class III peroxidase isoenzyme from tea leaves. Plant Physiol. 1997 Aug; 114(4):1237-45. PMID: 9276947.
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